Journals / Akademik Gastroenteroloji Dergisi / 2014 / Cilt: 13 - Sayı: 1

The correlation between leukocytosis and the severity of bleeding in patients with acute non-variceal upper gastrointestinal system bleeding

Varis dışı akut üst gastrointestinal sistem kanamalı hastalarda lökositoz ile kanama ciddiyeti arasındaki ilişki

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7–12
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⚡ TL;DR(Too Long; Didn't Read)

It seems that future studies performed in large patient series will facilitate leukocytosis taking its place among the clinical scoring systems used for upper gastrointestinal system bleedings.

📌 3 Key Takeaways

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Objective & Hypothesis:Background and Aims: Many studies have investigated the correla- tion between laboratory parameters checked at presentation to the hospital and the severity of bleeding in patients with acute non-variceal upper gastrointestinal system bleeding.
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Key Findings & Data:Materials and Meth- ods: Patients presenting to the emergency polyclinic of Haydarpaşa Numune Training and Research Hospital between 2006 and 2010 with the complaint of hematemesis and/or melena and admitted to the In- ternal Medicine Clinic due to upper gastrointestinal system bleeding with the detection of melena and/or hematemesis were included in the study.
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Conclusion & Impact:It seems that future studies performed in large patient series will facilitate leukocytosis taking its place among the clinical scoring systems used for upper gastrointestinal system bleedings.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

Background and Aims: Many studies have investigated the correla- tion between laboratory parameters checked at presentation to the hospital and the severity of bleeding in patients with acute non-variceal upper gastrointestinal system bleeding. In this study, we investigated the predictive value of leukocytosis determined at presentation to the hospital in predicting the severity of bleeding. Materials and Meth- ods: Patients presenting to the emergency polyclinic of Haydarpaşa Numune Training and Research Hospital between 2006 and 2010 with the complaint of hematemesis and/or melena and admitted to the In- ternal Medicine Clinic due to upper gastrointestinal system bleeding with the detection of melena and/or hematemesis were included in the study. Collection of demographic data, upper gastrointestinal en- doscopy findings, and pathological results of biopsies taken during the endoscopy was performed retrospectively. Only leukocyte values de- termined at presentation to the emergency polyclinic were taken into consideration. Results: Statistically significant differences were deter- mined between the groups regarding the number of leukocytes (p: 0,007), number of platelets (p: 0,039), blood urea nitrogen levels (p: 0,000), albumin levels (p: 0,006), requirement for erythrocyte suspen- sion replacement (p: 0,040), and requirement for fresh frozen plasma replacement (p: 0,045). Conclusions: The close association between leukocytosis and the markers of severe bleeding, such as blood urea nitrogen, requirement for erythrocyte suspension and fresh frozen plas- ma and hypoalbuminemia, shows that leukocytosis can be used as a parameter to help predict the severity of the clinical course at presenta- tion to the emergency polyclinic. The inability to determine a significant difference between the hospitalization periods can be attributed to the small numbers of patients in our study. It seems that future studies performed in large patient series will facilitate leukocytosis taking its place among the clinical scoring systems used for upper gastrointestinal system bleedings.

Özet

Giriş ve Amaç: Varis dışı üst gastrointestinal sistem kanamalı hastala- rın, hastaneye başvuru sırasında bakılan laboratuvar parametreleri ile kanamanın ciddiyeti arasındaki ilişkiyi araştıran birçok çalışma vardır. Biz de bu çalışmamızda hastaların başvuru sırasında tespit edilen lökosito- zun kanama ciddiyetini gösterme açısından prediktif değerini araştırdık. Gereç ve Yöntem: Çalışmaya 2006-2010 yılları arasında hastanemiz Haydarpaşa Numune Eğitim ve Araştırma Hastanesi acil polikliniğine hematemez ve/veya melena şikayeti ile başvuran, melena ve/veya he- matemezi saptanıp, üst gastrointestinal sistem kanama nedeniyle İç Hastalıkları kliniğine yatırılan hastalar alındı. Bu hastaların demografik bilgileri, üst gastrointestinal sistem endoskopi bulguları ve endoskopi sırasında alınan biyopsilerin patoloji sonuçları retrospektif olarak topla- narak kaydedildi. Hastaların yalnızca acil polikliniğe başvuru sırasındaki lökosit değerleri dikkate alındı. Bulgular: Gruplar arasında lökosit sayı- ları açısından istatistiki olarak anlamlı fark saptandı (p:0,007). Gruplar arasında platelet sayıları açısından (p:0,039), kan üre nitrojen düzeyleri açısından (p:0,000), albumin düzeyleri açısından (p:0,006), eritrosit süs- pansiyonu replasman ihtiyaçları açısından (p:0,040), taze donmuş plaz- ma replasman ihtiyaçları açısından istatistiki olarak anlamlı fark saptandı (p:0,045). Sonuç: Lökositoz ile ciddi kanama göstergeleri olan kan üre nitrojeni, eritrosit süspansiyonu ve taze donmuş plazma tarnsfüzyonu ihtiyacı ve hipoalbuminemi ile yakın ilişkili olması; lökositozun başvuru sırasında klinik seyrin ciddiyetini öngörmeye yardımcı olacak bir para- metre olarak kullanılabileceğini göstermekte iken hastane yatış sürele- ri arasında anlamlı fark tespit edilememiş olması hasta sayımızın kısıtlı olması ile ilişkilendirilebilir. Geniş hasta serilerinde yapılacak çalışmalar, lökositozun üst gastrointestinal sistem kanamalarında kullanılan klinik skorlamalarda yerini almasını sağlayabilecek gibi görünmektedir

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Cite This Article

KEÇECİ, M., SEVİNÇ, C., KAYATAŞ, K., KOÇHAN, K., ŞAHİN, A., DEMİRTAŞ, Z. E., FERHATOĞLU, F., ERSOY, E. Y., DEMİRTAŞ, R. (2014). The correlation between leukocytosis and the severity of bleeding in patients with acute non-variceal upper gastrointestinal system bleeding. Akademik Gastroenteroloji Dergisi, Cilt: 13 - Sayı: 1, 7–12. https://ajindex.com/articles/217453

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