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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2011 / Cilt: 17 - Sayı: 1

Açıklanamayan ve erkek faktör infertilitesi olan hastalarda ovaryen stimulasyon- intrauterin inseminasyon sikluslarında folikül gelişimi için gereken gonadotropin dozu prediktörleri

Predictors of total gonadotropin dose required for follicular growth in controlled ovarian stimulation with intrauterin insemination cycles in patients with unexplained infertility or male subfertility

Berna DİLBAZ
ENİS ÖZKAYA
MEHMET ÇINAR
Evrim ÇAKIR
Serdar DİLBAZ
Pages
28–33
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION: Our study results imply that basal BMI is the essential parameter in determining the total dose of gonadotropin used to achieve follicular growth.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: The aim of this study was to determine the possible predictors of total gonadotropin dose (TGD) required to achieve ovulation in patients with unexplained infertility or male subfertility.
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Key Findings & Data:STUDY DESIGN: A prospective study on 230 patients (n:178 unexplained infertility, n:52 male subfertility) scheduled for controlled ovarian stimulation (COH) and intrauterine insemination (IUI) was designed to determine the association between basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estrodiol (E2) levels, antral follicle count (AFC), age and body mass index (BMI) and total gonadotropin doses needed to achieve follicular growth.
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Conclusion & Impact:CONCLUSION: Our study results imply that basal BMI is the essential parameter in determining the total dose of gonadotropin used to achieve follicular growth.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The aim of this study was to determine the possible predictors of total gonadotropin dose (TGD) required to achieve ovulation in patients with unexplained infertility or male subfertility. STUDY DESIGN: A prospective study on 230 patients (n:178 unexplained infertility, n:52 male subfertility) scheduled for controlled ovarian stimulation (COH) and intrauterine insemination (IUI) was designed to determine the association between basal follicle stimulating hormone (FSH), luteinizing hormone (LH), estrodiol (E2) levels, antral follicle count (AFC), age and body mass index (BMI) and total gonadotropin doses needed to achieve follicular growth. RESULT: Regression analysis revealed an association between basal FSH level, BMI and AFC with total gonadotropin dose (P=0.001, P=0.002, P=0.045). BMI was positively correlated with TGD (r:0.400, P=0.001). Mean BMI of patients who required a total dosage of >1500 IUs of gonadotropin was 29.7±4.8kg/ m2 where as it was 24.9±3.2kg/ m2 for patients who received <1500 IU to achieve follicle growth (P=0.001). CONCLUSION: Our study results imply that basal BMI is the essential parameter in determining the total dose of gonadotropin used to achieve follicular growth.

Özet

AMAÇ: Bu çalışmada amaç açıklanamayan ve erkek faktör infertilitesi olan hastalarda ovaryen stimulasyon-intrauterin inseminasyon sikluslarında folikül gelişimi için gereken gonadotropin dozu prediktörlerini araştırmaktır. GEREÇ VE YÖNTEM: Bazal folikül stimüle edici hormon (FSH), luteinize edici hormon (LH), estrodiol (E2) levels, antral follikül sayısı (AFC), yaş ve vücut kitle indeksi (VKI) ile total gonadotropin doz arasındaki ilişki araştırılmak üzere ovaryen stimulasyon-inseminasyon prokolüne alınan 230 (178 açıklanamayan, 52 erkek faktör infertilitesi)hastada prospektif çalışma planlandı. BULGULAR: Regresyon analizinde FSH, AFC ve VKI ve total gonadotropin dozu arasında ilişki anlamlı saptandı (P=0,001, P=0,002, P=0,045). VKI total gonadotropin dozu ile anlamlı korele idi (r:0,400, P=0,001). Folikül gelişimi için 1500 ıu nün üstünde gonadotropin ihtiyacı olan hastaların ortalama VKI 29,7±4,8kg/ m2,1500 ıu nün altında gonadotropin ihtiyacı olan hastaların ortalama VKI 24,9±3,2kg/m2 . SONUÇ: Çalışmamızın sonuçlarına göre foliküler büyümeyi sağlayacak gonadotropin dozunu belirlemede VKI gerekli bir parametredir.

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Cite This Article

DİLBAZ, B., ÖZKAYA, E., ÇINAR, M., ÇAKIR, E., DİLBAZ, S. (2011). Açıklanamayan ve erkek faktör infertilitesi olan hastalarda ovaryen stimulasyon- intrauterin inseminasyon sikluslarında folikül gelişimi için gereken gonadotropin dozu prediktörleri. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 17 - Sayı: 1, 28–33. https://ajindex.com/articles/216918

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