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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2011 / Cilt: 17 - Sayı: 1

İnsan endometriumunda mensturual siklusta ve gestasyonda galektin-3 ekspresyonu

Galectin-3 expression in human endometrium and decidua during the menstrual cycle and in gestation

Nevra DURSUN
Melin GEÇER ÖZGÜN
Pelin YILDIZ
Cem LEBLEBİCİ
Erol Rüştü BOZKURT
Nimet KARADAYI
Fadime BAHADIR
Pages
24–27
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This shows that G3 plays an important role in implantation.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: G3 is one of the members of the lectin family that may be involved in the establishment of endometrial receptivity by regulating the proliferation and adhesion of endometrial cells.
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Key Findings & Data:STUDY DESIGN: Immunohistochemical expression of G3 was tested in late secretory phase of the endometrium (SPE)(n=30), proliferative phase of the endometrium (PPE)(n=34), and decidua (n=41) and induced abortions in the first trimester.
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Conclusion & Impact:This shows that G3 plays an important role in implantation.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: G3 is one of the members of the lectin family that may be involved in the establishment of endometrial receptivity by regulating the proliferation and adhesion of endometrial cells. STUDY DESIGN: Immunohistochemical expression of G3 was tested in late secretory phase of the endometrium (SPE)(n=30), proliferative phase of the endometrium (PPE)(n=34), and decidua (n=41) and induced abortions in the first trimester. RESULTS: Expression of G3 during the PPE was low; 12 cases were score 1 and 19 cases were score 2 (p<0.001). However, among the late SPE, there were 11 cases at score 2, and 15 cases at score 3. In the decidua expression of G3, 37 cases were score 3 (p<0.001). CONCLUSION: There is a significant progression of G3 expression in SPE and gestation. Although during the PPE expression is considerably lower. This shows that G3 plays an important role in implantation.

Özet

AMAÇ: Lektin ailesinin üylerinden biri olan Galektin-3 (G3) endometrial hücrelerin adezyonunu ve proliferasyonunu düzenleyerek endometrial resepsivitenin oluşumuna dahil edilebilir. GEREÇ VE YÖNTEM: G3’ün endometriumun geç sekretuar (SPE) (n=30), proliferative (PPE) (n=34) fazında, ve ilk trimester abortus materyallerinin desidual dokularında (n=41) immunhistokimyasal olarak G3 ekspresyonu test edildi. BULGULAR: G3’ün PPE’deki ekspresyonu düşüktü, 12 olgu skor 1, 19 olgu skor 2’idi (p<0,001). Ancak geç SPE olgularında 11 olgu skor 2, ve 15 olgu skor 3 izlendi. Desiduada ise 37 olgu skor 3 boyanma gösterdi (p<0,001). SONUÇ: SPE ve gestasyonda G3 ekspresyonunda belirgin progresif bir ekspresyon mevcuttur. Ancak PPE SIRASINDA ekspresyonbelirgin olarak düşüktür.. Bu G3’ün implantasyonda önemli bir rolü olduğunu göstermektedir.

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Cite This Article

DURSUN, N., ÖZGÜN, M. G., YILDIZ, P., LEBLEBİCİ, C., BOZKURT, E. R., KARADAYI, N., BAHADIR, F. (2011). İnsan endometriumunda mensturual siklusta ve gestasyonda galektin-3 ekspresyonu. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 17 - Sayı: 1, 24–27. https://ajindex.com/articles/216917

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