SavedAdd your journal

Journals / Diagnostic and Interventional Radiology / 2005 / Cilt: 11 - Sayı: 3

Evaluation of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder

Kamran MAHMUTYAZICIOĞLU
NUMAN KONUK
Hüseyin ÖZDEMİR
Nuray ATASOY
LEVENT ATİK
Sadi GÜNDOĞDU
Pages
125–129
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Further studies with MRS in larger patient populations are needed to clarify the relationship between brain structures and neurobiology of PTSD.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:PURPOSE Previous studies have shown that post-traumatic stress disorder (PTSD) is associated with lymbic system dysfunction.
📊
Key Findings & Data:MATERIALS AND METHODS Single voxel MRS was performed in 10 PTSD patients and 6 healthy subjects in two cerebral areas highly involved in the pathophysiology of PTSD (the hippocampus and the anterior cingulate gyrus).
💡
Conclusion & Impact:Further studies with MRS in larger patient populations are needed to clarify the relationship between brain structures and neurobiology of PTSD.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Olgu-kontrol çalışmaları · Stres bozuklukları · travma sonrası

Abstract

PURPOSE Previous studies have shown that post-traumatic stress disorder (PTSD) is associated with lymbic system dysfunction. The purpose of this study is to evaluate whether or not the neuronal integrity in hippocampus and anterior cingulate gyrus is affected in PTSD as assessed by proton magnetic resonance spectroscopy. MATERIALS AND METHODS Single voxel MRS was performed in 10 PTSD patients and 6 healthy subjects in two cerebral areas highly involved in the pathophysiology of PTSD (the hippocampus and the anterior cingulate gyrus). Spectra were obtained using PRESS sequence. Voxel sizes were 3.7 cm3 (hippocampus) and 6-7.2 cm3 (anterior cingulate gyrus). Metabolite ratios of NAA/Cr and Cho/Cr were calculated and compared to the control subjects. The severity of PTSD in the patient group was evaluted by Clinician-Administered PTSD Scale. RESULTS Analysis of the proton MR spectra showed reductions in NAA/Cr ratio in bilateral hippocampus of PTSD subjects as compared to normal controls (p<0.001), whereas Cho/Cr ratios were increased (p<0.001). Reductions in NAA/Cr ratio were found in the the anterior cingulate gyrus of PTSD subjects as compared to normal controls (p<0.01), whereas Cho/Cr ratios did not differ significantly (p>0.05). CONCLUSION Changes in the metabolite ratios provide support for either neuronal dysfunction or neuronal loss both in the hippocampus and the anterior cingulate gyrus and may be associated with reduced neuronal integrity. Further studies with MRS in larger patient populations are needed to clarify the relationship between brain structures and neurobiology of PTSD.

🔖

Cite This Article

MAHMUTYAZICIOĞLU, K., KONUK, N., ÖZDEMİR, H., ATASOY, N., ATİK, L., GÜNDOĞDU, S. (2005). Evaluation of the hippocampus and the anterior cingulate gyrus by proton MR spectroscopy in patients with post-traumatic stress disorder. Diagnostic and Interventional Radiology, Cilt: 11 - Sayı: 3, 125–129. https://ajindex.com/articles/216106

References (14)

  1. Pine DS. Anxiety disorders: clinical features. In: Sadock BJ, Sadock VA, eds. Kaplan and Sadock’s Comprehensive Textbook of Psychiatry. 7th ed. Philadelphia: Lippincott Williams and Wilkins, 2000; 1476-1490
  2. Shalev AY Posttraumatic stress disorder: diagnosis, history and life course. In: Nutt D, Davidson JRT, Zohar J, eds. Post-traumatic Stress Disorder: Diagnosis Management and Treatment. London: Martin Dunitz Ltd, 2000; 1-12
  3. Freeman TW, Cardwell D, Karson CN, Komoroski RA. In vivo proton magnetic resonance spectroscopy of the medial temporal lobes of subjects with combat-related posttraumatic stress disorder. Magn Reson Med 1998; 40:66-71
  4. Schuff N, Neylan TC, Lenoci MA, et al. Decreased hippocampal N-acetyl aspartate in the absence of atrophy in posttraumatic stress disorder. Biol Psychiatry 2001; 50:952-959
  5. Schuff N, Marmar CR, Weiss DS, et al. Reduced hippocampal volume and N-acetyl aspartate in posttraumatic stress disorder. Ann N Y Acad Sci 1997; 821:516-520
  6. Pissiota A, Frans O, Fernandez M, von Knorring L, Fischer H, Fredrikson M. Neurofunctional correlates of posttraumatic stress disorder: a PET symptom provocation study. Eur Arch Psychiatry Clin Neurosci 2002; 252:68-75
  7. Amerikan Psikiyatri Birliği: Mental Bozuklukların Tanısal ve Sayımsal El Kitabı, 4. baskı (DSM IV), Amerikan Psikiyatri Birliği, Washington DC, 1994. Köroğlu E, çeviri ed. Hekimler Yayın Birliği, Ankara, 1994; 179-194
  8. Aker AT, Özeren M, Başoğlu M, Kaptanoğlu C, Erol A, Buran B. Klinisyen Tarafından Uygulanan Travma Sonrası Stres Bozukluğu Ölçeği (TSSB-Ö) geçerlik ve güvenilirlik çalışması. Türk Psikiyatri Dergisi 1999; 10:286-293
  9. Scheltens P, Leys D, Barkhof F, et al. Atrophy of medial temporal lobes on MRI in "probable" Alzheimer's disease and normal aging: diagnostic value and neuropsychological correlates. J Neurol Neurosurg Psychiatry 1992; 55:967-972
  10. Galton CJ, Gomez-Anson B, Antoun N, et al. Temporal lobe rating scale: application to Alzheimer’s disease and frontotemporal dementia. J Neurol Neurosurg Psychiatry 2001; 70:165-173
  11. Hull AM. Neuroimaging findings in posttraumatic stress disorder. Systematic review. Br J Psychiatry 2002; 181:102-110
  12. Vermetten E, Bremner JD. Circuits and systems in stress. I. Preclinical studies. Depress Anxiety 2002; 15:126-147
  13. Hamner MB, Lorberbaum JP, George MS. Potential role of the anterior cingulate cortex in PTSD: review and hypothesis. Depress Anxiety 1999; 9:1-14
  14. Villarreal G, Hamil