Journals / Haseki Tıp Bülteni / 2015 / Cilt: 53 - Sayı: 3

Evaluation of Risk Factors for Hepatosteatosis in Gall Stone Disease

Kolelitiazisli Hastalarda Hepatosteatoz Risk Faktörlerinin Değerlendirilmesi

Pages
237–240
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Obesity, female gender, age, type 2 DM, hypertriglyceridemia, insulin resistance, metobolic syndrome, fast weight loss, and bile stasis are risk factors for cholelithiasis. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 237-40)

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: It has been reported that non-alcoholic fatty liver disease (NAFLD) was associated with cholecystectomy and cholecystectomy that may be a risk factor for the development of non-alcoholic fatty liver disease.
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Key Findings & Data:Methods: In this study, we included 204 consecutive patients who underwent elective cholecystectomy between June 2011 and January 2014 due to cholelythiasis.
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Conclusion & Impact:Obesity, female gender, age, type 2 DM, hypertriglyceridemia, insulin resistance, metobolic syndrome, fast weight loss, and bile stasis are risk factors for cholelithiasis. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 237-40)
🔬Design:Research Article
📍Scope:2011 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: It has been reported that non-alcoholic fatty liver disease (NAFLD) was associated with cholecystectomy and cholecystectomy that may be a risk factor for the development of non-alcoholic fatty liver disease. In this sense, we studied the other risk factors for non- alcoholic fatty liver disease in patients with cholelythiasis. Methods: In this study, we included 204 consecutive patients who underwent elective cholecystectomy between June 2011 and January 2014 due to cholelythiasis. We retrospectively evaluated the files of the patients, including operative findings, history, laboratory and radiological imaging findings obtained from the hospital information system and the archived contents of the files. Results: There was no significant relationship between the number and size of the stones and hepatic steatosis (p=0.83 and p=0.96, respectively). Besides, there was no statistically significant relationship between gender and hepatosteatosis. In multivariate regression, obesity, type 2 diabetes mellitus (DM) and cholelithiasis were identified as an independent risk factor for NAFLD. Conclusion: NAFLD and cholelithiasis are common in the general population and have common risk factors. Obesity, female gender, age, type 2 DM, hypertriglyceridemia, insulin resistance, metobolic syndrome, fast weight loss, and bile stasis are risk factors for cholelithiasis. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 237-40)

Özet

Amaç: Yapılan çalışmalarda non-alkolik yağlı karaciğer hastalığının (NAYKH) kolesistektomi ile ilişkili olduğu ve kolesistektominin kendisinin non-alkolik yağlı karaciğer hastalığı gelişimi için bir risk faktörü olabileceği bildirilmiştir. Bu düşünceden yola çıkarak kolelitiazisli hastalarda NAYKH’ye neden olabilecek risk faktörlerini inceledik. Yöntemler: Bu çalışmaya Haziran 2011 ve Ocak 2014 arasında kolelitiazis nedeniyle elektif koşullarda kolesistektomi yapılan ardışık 204 hasta dahil edildi. Hastaların dosyaları, ameliyat bulguları, geçmiş laboratuvar ve radyolojik görüntüleme bulguları hastane bilgi sisteminden ve arşivlenen dosya içeriğinden retrospektif olarak tarandı. Bulgular: Yapılan istatiksel değerlendirmede taşların sayı ve boyutu ile hepatosteatoz arasında da anlamlı bir ilişki saptanmadı (sırasıyla p=0,83 ve p=0,96). Cinsiyet ile hepatosteatoz arasında istatiksel olarak anlamlı bir ilişki saptanmadı (p=0,47). Multivariate regresyonda NAYKH için obezite, tip 2 diabetes mellitus (DM) ve kolelitiazis bağımsız risk faktörü olarak saptanmıştır. Sonuç: NAYKH ve kolelitiazis toplumda sık görülür ve ortak risk faktörlerini içerir. Obezite, bayan cinsiyet, yaş, tip 2 DM, hipertrigliseridemi, insülin direnci, metabolik sendrom, hızlı kilo kaybı ve safra stazı kolelitiazis için risk faktörüdür. (Ha­se­ki T›p Bül­te­ni 2015; 53: 237-40)

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Cite This Article

SAVAŞ, O. A., ÜÇÜNCÜ, M. Z., ÖZER, B., GÜRBULAK, B., GÜR, H. Ü., TÜZÜN, İ. S., FERLENGEZ, E., KEKLİKKIRAN, Z. Z., KOYUNCU, A. (2015). Evaluation of Risk Factors for Hepatosteatosis in Gall Stone Disease. Haseki Tıp Bülteni, Cilt: 53 - Sayı: 3, 237–240. https://ajindex.com/articles/216038

References (17)

  1. Nervi F, Arrese M. Cholecystectomy and NAFLD: does gallbladder removal have metabolic consequences? Am J Gastroenterol 2013;108:959-61
  2. Lambou-Gianoukos S, Heller SJ. Lithogenesis and bile metabolism. Surg Clin North Am 2008;88:1175-94
  3. Smelt AH. Triglycerides and gallstone formation. Clin Chim Acta 2010;411:21-22
  4. Adams LA, Waters OR, Knuiman MW, Elliott RR, Olynyk JK. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am J Gastroenterol 2009;104:861-7
  5. Targher G, Day CP, Bonora E. Risk of cardiovascular disease in patients with nonalcoholic fatty liver disease. N Engl J Med 2010;363:1341-50
  6. Noel RA, Braun DK, Patterson RE, Bloomgren GL. Increased risk of acute pancreatitis and biliary disease observed in patients with type 2 diabetes: a retrospective cohort study. Diabetes Care 2009;32:834-8
  7. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Statin use and the risk of cholecystectomy in women. Gastroenterology 2009;136:1593-600
  8. Ioannou GN. Cholelithiasis, cholecystectomy, and liver disease. Am J Gastroenterol 2010;105:1364-73
  9. Fracanzani AL, Valenti L, Russello M, et al. Gallstone disease is associated with more severe liver damage in patients with non-alcoholic fatty liver disease. PLoS One 2012;7:e41183
  10. Vernon G, Baranova A, Younossi ZM. Systematic review: the epidemiology and natural history of non-alcoholic fatty liver disease and non- alcoholic steatohepatitis in adults. Aliment Pharmacol Ther 2011;34:274-85
  11. Marchesini G, Brizi M, Bianchi G, et al. Nonalcoholic fatty liver disease: a feature of the metabolic syndrome. Diabetes 2001;50:1844-50
  12. Younossi ZM. Review article: current management of non- alcoholic fatty liver disease and non-alcoholic steatohepatitis. Aliment Pharmacol Ther 2008;28:2-12
  13. Yilmaz Y, Kurt R, Yonal O, et al. Coronary flow reserve is impaired in patients with nonalcoholic fatty liver disease: association with liver fibrosis. Atherosclerosis 2010;211:182- 6
  14. Stinton LM, Myers RP, Shaffer EA. Epidomiology of gallstones. Gasroenterol Clin North Am 2010;39:157-69
  15. Tsai CJ, Leitzmann MF, Willett WC, Giovannucci EL. Prospective study of abdominal adiposity and gallstone disease in US men. Am J Clin Nutr 2004;80:38-44
  16. Gurusamy KS, Davidson BR. Surgical treatment of gallstones. Gastroenterol Clin North Am 2010;39:229-44
  17. Portincasa P, Moschetta A, Palasciano G. Cholesterol gallstone disease. Lancet 2006;368: