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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2011 / Cilt: 17 - Sayı: 1

Gebelerde komplike olmayan üriner sistem enfeksiyonunun tedavisi: Tek doz fosfomycin tromethamine vs. multipl doz nitrofurantoin

Treatment of non - complicated lower urinary tract infection in pregnancy: Single dose fosfomycin tromethamine versus multiple dose nitrofurantoin

Murat ÖZEL
Oktay KAYMAK
Nüvit BİRGİLİ
Şevki ÇELEN
Mine ERDOĞAN
Nuri DANIŞMAN
Pages
20–23
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

FT is an effective, safe, single dose treatment choice in the management of uncomplicated lower UTI in pregnant women

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: To evaluate the efficacy of single-dose fosfomycin tromethamine (FT) treatment in pregnant women with uncomplicated lower urinary tract infection (UTI).
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Key Findings & Data:STUDY DESIGN: In this study, 421 pregnant women with established, symptomatic, uncomplicated lower UTI were randomly allocated to receive either a single dose of FT (Monurol®, Zambon Group S.p.A, Milan-ITALY) (n=217) or a 7-day course of nitrofurantoin (n=204).
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Conclusion & Impact:FT is an effective, safe, single dose treatment choice in the management of uncomplicated lower UTI in pregnant women
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: To evaluate the efficacy of single-dose fosfomycin tromethamine (FT) treatment in pregnant women with uncomplicated lower urinary tract infection (UTI). STUDY DESIGN: In this study, 421 pregnant women with established, symptomatic, uncomplicated lower UTI were randomly allocated to receive either a single dose of FT (Monurol®, Zambon Group S.p.A, Milan-ITALY) (n=217) or a 7-day course of nitrofurantoin (n=204). The treatment was found to be effective if urine culture was negative 15 days after therapy. RESULTS: Microbiological cure was achieved in 205 (94.5%) patients treated with FT and 164 (80.4%) patients treated with nitrofurantoin (p<0.05). Pathogen microorganisms were predominantly E.coli (199 in FT and 183 in NF group) followed by Klebsiella (18 in FT and 21 in NF group). CONCLUSION: The treatment of acut lower UTI in pregnant women is essential. FT is an effective, safe, single dose treatment choice in the management of uncomplicated lower UTI in pregnant women

Özet

AMAÇ: Komplike olmayan alt üriner sistem enfeksiyonu olan gebe kadınlarda tek doz fosfomisin tromethamine (FT) tedavisinin yararının değerlendirilmesi GEREÇ VE YÖNTEM: Bu çalışmada, semptomatik, komplike olmayan alt üriner sistem enfeksiyonu ispatlanmış 421 gebe kadın rastgele tek doz FT(Monurol®, Zambon Group S.p.A, Milan-ITALY)(n=217) ve 7 gün süreli nitrofurantoin (n=204) tedavi gruplarına ayrıldı.İdrar kültürü tedaviden 15 gün sonra negatif ise tedavinin yararlı olduğu bulundu. BULGULAR: FT ile tedavi edilen 205(%94.5) hastada ve nitrofurantoin ile tedavi edilen 164 (%80.4) hastada mikrobiyolojik kür elde edildi (p<0.05).Patojen mikroorganizmalar baskın olarak E.coli (199 FT ve 183 NF grupta) takiben Klebsiella (18 FT and 21 NF grupta) idi. SONUÇ: Gebe kadınlarda akut alt ÜSE tedavisi gereklidir.FT gebe kadınlarda komplike olmayan alt ÜSE yönetiminde yararlı, güvenli, tek doz tedavi seçimidir.

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Cite This Article

ÖZEL, M., KAYMAK, O., BİRGİLİ, N., ÇELEN, Ş., ERDOĞAN, M., DANIŞMAN, N. (2011). Gebelerde komplike olmayan üriner sistem enfeksiyonunun tedavisi: Tek doz fosfomycin tromethamine vs. multipl doz nitrofurantoin. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 17 - Sayı: 1, 20–23. https://ajindex.com/articles/215415

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