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Journals / Erciyes Medical Journal / 2019 / Cilt: 41 - Sayı: 1

Characteristics of Mesenchymal Stem Cells Derived From the Apical Papilla of a Supernumerary Tooth Compared to Stem Cells Derived From the Dental Pulp

ZEYNEP BURÇİN GÖNEN
Selami DEMİRCİ
AYŞEGÜL DOĞAN
Ayşegül SARDOĞAN
Abdullah EKİZER
Alper ALKAN
FİKRETTİN ŞAHİN
Pages
18–24
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Overall, ST-APSCs were characterized by their MSC properties and were able to differentiate into three cell lineages.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: There are several comparative studies that were conducted to explain the specific properties of oral tissue derived mesenchymal stem cells (MSC).
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Key Findings & Data:However, DPSCs derived from a wisdom tooth demonstrated more differentiation potential to osteo- and chondro-genic cell types compared to ST-APSCs.
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Conclusion & Impact:Conclusion: Overall, ST-APSCs were characterized by their MSC properties and were able to differentiate into three cell lineages.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objective: There are several comparative studies that were conducted to explain the specific properties of oral tissue derived mesenchymal stem cells (MSC). However, apical papilla stem cells derived from supernumerary teeth (ST-APSCs) have not been characterized for their MSC properties yet. Materials and Methods: In the present study, ST-APSCs were isolated and characterized from a nonsyndromic male patient to evaluate the MSC characteristics. Dental pulp stem cells (DPSCs) and ST-APSCs were isolated and characterized for mesenchymal surface markers. Cells were differentiated into osteo-, chondro-, and adipogenic cell types. Results: Both cell types expressed the MSC surface markers. When DPSCs and ST-APSCs were cultured in differentiation media promoting transformation to osteo-, chondro-, and adipo-genic lineages, both showed calcium mineralization, chondrogenic mass formation, and lipid accumulation. However, DPSCs derived from a wisdom tooth demonstrated more differentiation potential to osteo- and chondro-genic cell types compared to ST-APSCs. Conclusion: Overall, ST-APSCs were characterized by their MSC properties and were able to differentiate into three cell lineages. However, they were less potent for osteo- and chondro-genic cell lineage specification compared to DPSCs derived from a wisdom tooth.

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Cite This Article

GÖNEN, Z. B., DEMİRCİ, S., DOĞAN, A., SARDOĞAN, A., EKİZER, A., ALKAN, A., ŞAHİN, F. (2019). Characteristics of Mesenchymal Stem Cells Derived From the Apical Papilla of a Supernumerary Tooth Compared to Stem Cells Derived From the Dental Pulp. Erciyes Medical Journal, Cilt: 41 - Sayı: 1, 18–24. https://ajindex.com/articles/215327

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