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Journals / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 6

The increase of mean platelet volume in patients with Alzheimer disease

Emine Rabia KOÇ
Ertuğrul UZAR
Yasemin ÇIRAK
Yasemin Parlak DEMİR
Atilla İLHAN
Pages
1060–1066
Publication Date
2014-06-01
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Vascular risk factors play an important role in the progression of Alzheimer disease (AD).
📊
Key Findings & Data:Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation.
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Conclusion & Impact:The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Alzheimer disease · dementia · cognitive decline

Abstract

Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE => 18) and moderate (MMSE < 18), and their MPV levels were compared. Results: MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values. Conclusion: Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.

Özet

Vascular risk factors play an important role in the progression of Alzheimer disease (AD). Mean platelet volume (MPV) is a determinant of platelet functionality and increased MPV is associated with an increased risk of vascular inflammation. Here we aimed to examine whether MPV could be used as a marker of vascular damage in AD and to discuss the relation between MPV and other vascular risk factors. Materials and methods: A total of 109 outpatients with AD and 81 healthy controls were included in this study. Diagnosis of AD was made according to defined criteria. The Turkish version of the Mini Mental State Examination (MMSE) was used for cognitive assessment. According to the test results, patients were divided into 2 subgroups, mild (MMSE => 18) and moderate (MMSE < 18), and their MPV levels were compared. Results: MPV levels were higher in the AD group. There was no statistically significant difference between the moderate group and the mild group according to MPV values. Conclusion: Increased MPV in patients with AD may point to platelet dysfunction. MPV is an indicator of increased in vivo platelet activation. Hence, platelets could be the link between vascular risk factors and AD. The assessment of MPV in patients with AD may help identify the patients that could benefit from additional antiplatelet therapy.

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Cite This Article

KOÇ, E. R., UZAR, E., ÇIRAK, Y., DEMİR, Y. P., İLHAN, A. (2014). The increase of mean platelet volume in patients with Alzheimer disease. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 6, 1060–1066. https://ajindex.com/articles/215206

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