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Journals / Gülhane Tıp Dergisi / 2003 / Cilt: 45 - Sayı: 1

Aktif protein C rezistansı venöz tromboz rskini artırır: Açıklanamayan trombozlu 104 hastada prospektif bir çalışma

Activated protein C resistance increases the risk of venous thrombosis: A prospective study in 104 patients with unexplained thrombosis

Muhammed Wael ABUGHOUSH
Münzer Al RASHED
Pages
14–18
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

In parallel to light of the medical literature information, high prevalence of activated protein C resistance among young persons with history of venous thrombosis was re-emphasized.

📌 3 Key Takeaways

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Objective & Hypothesis:Resistance to activated protein C (APC) is fairly com-mon inherited risk factor for venous thrombosis.
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Key Findings & Data:In this study we determined the activated protein C resistance in 104 patients with deep vein thrombosis (DVT) with a mean age of 35 years.
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Conclusion & Impact:In parallel to light of the medical literature information, high prevalence of activated protein C resistance among young persons with history of venous thrombosis was re-emphasized.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Antitrombin III · Protein S · Protein C

Abstract

Resistance to activated protein C (APC) is fairly com-mon inherited risk factor for venous thrombosis. The inherited abnormality is recently being considered to be a major hereditary disorder associated with elevated risk of venous thrombosis. In this study we determined the activated protein C resistance in 104 patients with deep vein thrombosis (DVT) with a mean age of 35 years. Protein C (PC) and Protein S (PS) activities as well as antithrombin III (ATIII) levels were also determined. Control group was comprised of 110 healthy, age and sex matched individuals. Activated protein C resistance positivity was determined as 33.6% and 4.5% (p<0.001) in deep vein thrombosis patients and control group, respectively. In parallel to light of the medical literature information, high prevalence of activated protein C resistance among young persons with history of venous thrombosis was re-emphasized.

Özet

Aktive olmuş protein C rezistansı (APC), venöz tromboz için oldukça sık görülen kalıtımsal bir risk faktörüdür. Son zamanlarda bu kalıtımsal anormallik, artmış venöz tromboz riski ile ilişkili ana genetik bozukluk olabileceği değerlendirilmektedir. Bu çalışmada, ortalama yaşları 35 olan derin ven trombozlu (DVT) 104 hastada aktive protein C rezistansı fenotipleri belirlendi. Antitrombin III (AT III) gibi Protein C (PC) ve Protein S (PS) aktiviteleride saptandı. Yaş ve cinsiyet bakımından hasta grubu ile uyumlu 110 sağlıklı bireyden, kontrol grubu oluşturuldu. Aktive protein C rezistans pozitifliği, derin ven trombozlu hastalarda ve kontrol grubunda, sırası ile %33.6 ve %4.5 bulundu (p<0.001). Literatür bilgilerine paralel olarak, ailesinde venöz tromboz hikayesi bulunan genç hastalarda aktive protein C rezistansı sıklığının yüksek olduğu belirlendi.

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Cite This Article

ABUGHOUSH, M. W., RASHED, M. A. (2003). Aktif protein C rezistansı venöz tromboz rskini artırır: Açıklanamayan trombozlu 104 hastada prospektif bir çalışma. Gülhane Tıp Dergisi, Cilt: 45 - Sayı: 1, 14–18. https://ajindex.com/articles/214921

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