AI Summary & Key Takeaways
AI InsightCONCLUSIONS: Blood HDL cholesterol levels measured at delivery were reduced in patients with preeclampsia, and patients with reduced levels of HDL cholesterol had a substantially higher probability of the disease severity in comparision to those with mild preeclampsia or those controls.
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Abstract
OBJECTIVE: Low serum levels of high-density lipoprotein (HDL) cholesterol have been found to be associated with the severity of the inflammatory disorders. Moreover; it has been shown that preeclampsia is a disorder of immune system with predominant involvement of proinflammatory molecules. Therefore the purpose of the present study was to assess whether blood serum HDL cholesterol levels could be used as a predictor of the severity of preeclampsia. STUDY DESIGN: Forty women with preeclampsia were recruited and thirty-five normal pregnant women were matched for both maternal age and gestastional age served as control. The materials were collected immediately after delivery of the fetus, before placenta expulsion and before clumping of the umblical cord in patients and controls whom were in fasting state. Total cholesterol, HDL cholesterol, triglyceride (TG) and low-density lipoprotein (LDL) cholesterol levels were assessed. RESULTS: Among the preeclamptic women, 12 were diagnosed with severe preeclampsia and 28 mild. There were no statistically significant differences between preeclampsia and normal pregnancy except when divided by according to systolic and diastolic blood pressure, proteinuria levels, parity, and HDL cholesterol levels. Of the women with preeclampsia (n=40), 30 % had severe disease. Women with mild and severe preeclampsia had significiantly higher blood pressures at delivery and earlier gestational ages in comparision to control subjects. Although TG, VLDL and LDL levels (p>0.05) were comparable between preeclampsia and normal pregnancies, HDL cholesterol levels were significiantly lower in patients with preeclampsia. Moreover, in subgroup analysis, patients with severe preeclampsia had the lower HDL levels (p<0.05) in comparision with mild preeclampsia. CONCLUSIONS: Blood HDL cholesterol levels measured at delivery were reduced in patients with preeclampsia, and patients with reduced levels of HDL cholesterol had a substantially higher probability of the disease severity in comparision to those with mild preeclampsia or those controls.
Özet
GİRİŞ: Düşük yüksek dansiteli lipoprotein (HDL) düzeyi ile inf lamasyonun ciddiyeti arasındaki ilişki bilinmektedir. Preek GEREÇ VE YÖNTEM: Yaş ve gestasyonel yaş bakımından benzer preeklampsi tanısı almış 40 ve 35 sağlıklı gebe çalışmaya dahil edildi. Kan örnekleri fetusun doğumundan hemen sonra umblikal kord bağlanmadan önce toplandı. Total kolesterol, HDL kolesterol, trigliserid ve düşük dansiteli lipoprotein seviyelerine bakıldı. BULGULAR: Preeklamptik hastaların 12’si ağır, 28’i hafif idi. Hasta grupları arasında sistolik ve diyastolik kan basıncı, proteinürü seviyesi, parite, HDL kolesterol düzeyleri hariç aralarında anlamlı fark saptanmadı. Ağır ve hafif preeklamptik hastalar kontrol grubuna göre daha yüksek kan basınçlarına ve erken gestasyonel yaşa sahiptiler. Preeklamptik hastalar ve kontrol grubunda benzer TG, VLDL and LDL düzeyleri olmasına rağ men (p>0,05), HDL düzeyleri preeklamptik hastalarda anlamlı derecede düşüktü (p<0,05). Daha da ötesi alt grup analizde ağır preeklamptik hastalar hafif preeklamptik hastalara göre daha düşük HDL seviyelerine sahipti (p<0,05). SONUÇ: Doğum sırasında ölçülen kan HDL kolesterol düzeyleri preeklamptik bayanlarda azalmıştır ve azalmış HDL kolesterol düzeyleri hastalığın ciddiyeti ile ilişkilidir. lampsinin de proinflamatuar moleküllerin öncülük ettiği immün sistem hastalığı olduğu gösterilmiştir. Çalışmamızın amacı kan HDL seviyelerinin preeklampsinin ciddiyetini belirlemedeki rolünü araştırmaktır.