Journals / Haseki Tıp Bülteni / 2015 / Cilt: 53 - Sayı: 3

Disseminated Intravascular Coagulation in a Case of Gastric Adenocarcinoma

Gastrik Adenokarsinom Olgusunda Gelişen Yaygın Damar İçi Pıhtılaşma

Pages
251–252
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Since gastric adenocarcinoma complicated by DIC has a fatal clinical feature, early diagnosis is of great importance. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 251-2)

📌 3 Key Takeaways

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Objective & Hypothesis:Disseminated intravascular coagulation (DIC) is characterized by the activation of the extrinsic and intrinsic clotting cascade.
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Key Findings & Data:In this case paper, we present a 53-year- old patient who was admitted to the hospital with the complaint of weariness.
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Conclusion & Impact:Since gastric adenocarcinoma complicated by DIC has a fatal clinical feature, early diagnosis is of great importance. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 251-2)
🔬Design:Research Article
📍Scope:2015 Verileri
⚙️Variables:Domain Parameters

Abstract

Disseminated intravascular coagulation (DIC) is characterized by the activation of the extrinsic and intrinsic clotting cascade. There is always an underlying condition such as infection, solid tumors and hematologic malignancies. In this case paper, we present a 53-year- old patient who was admitted to the hospital with the complaint of weariness. Thrombocytopenia, prolongation of the prothrombin time, a low fibrinogen level and enhanced plasma fibrin degradation products were determined, thus, the diagnosis of DIC was established. Endoscopy and gastric biopsy were performed, because of high levels of tumor markers and anemia. Pathological investigation showed the findings of signet ring cell mucinous adenocarcinoma. In this case the cause of DIC was gastric adenocarcinoma. Since gastric adenocarcinoma complicated by DIC has a fatal clinical feature, early diagnosis is of great importance. (The Me­di­cal Bul­le­tin of Ha­se­ki 2015; 53: 251-2)

Özet

Yaygın damar içi pıhtılaşma (YDP), ekstrinsink ve intrinsink pıhtılaşma yolarının uyarılması ile karakterizedir. Pıhtılaşma faktörleri ve trombositler tüketilir ve kanama gözlenir. Genellikle enfeksiyon, solid tümör, hematolojik malignite gibi altta yatan bir nedene bağlıdır. Sunduğumuz olguda, hastaneye geliş sırasında yapılan tetkikler sonucu trombositopeni, protrombin zamanında uzama, fibrin yıkım ürünlerinde artma, fibrinojen düşüklüğü ve periferik yaymada fragmente eritrositler saptanarak YDP tanısı konulmuş ve gerekli tedavi düzenlemiştir. Etiyolojiye yönelik incelemeler yapılmış ve endoskopi ile alınan gastrik biyopside taşlı yüzük hücreli müsinöz adenokarsinom saptanmıştır. Bu sunum, gastrik adenokarsinom olgusunda tanı sırasında gelişen YDP tablosunun, sık karşılaşılmayan bir durum olması sebebiyle yapılmıştır. (Ha­se­ki T›p Bül­te­ni 2015; 53: 251-2)

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Cite This Article

ÇAVUŞOĞLU, B., AHBAB, S., ÇETİN, F., ATAOĞLU, H. E., YENİGÜN, M. (2015). Disseminated Intravascular Coagulation in a Case of Gastric Adenocarcinoma. Haseki Tıp Bülteni, Cilt: 53 - Sayı: 3, 251–252. https://ajindex.com/articles/214732

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References (1)

  1. Kaynaklar 1. Franchini M, Lippi G, Manzato F. Recent acquisitions in the pathophisiology, diagnosis and treatment of disseminated intravacular coagulation. Thromb J 2006;4:4. 2. Demphle CE. Predicting disseminated intravacular coagulation in the intensive care unit. Hematology 2006;2:235-38. 3. Levi M. Disseminated intravascular coagulation: What’s new? Crit Care Clin 2005;21:449-67. 4. Wada H. Disseminated intravascular coagulation. Clin Chim Acta 2004;344:13-21. 5. Koneko T, Wada H. Diagnostic criteria and laboratory tests for disseminated intravascular coagulation. J Clin Exp Hematop 2011;51:67-76.