Gadolinium deposition in the brain: another concern regarding gadolinium-based contrast agents

References (2)

1. Karabulut N, Elmas N. Contrast agents used in MR imaging of the liver. Diagn Interv Radiol 2006; 12:22-30. Grobner T. Gadolinium--a specific trigger for the development of nephrogenic fibrosing dermopathy and nephrogenic systemic fibro- sis? Nephrol Dial Transplant 2006; 21:1104- 1108. [CrossRef] Marckmann P, Skov L, Rossen K, et al. Nephro- genic systemic fibrosis: suspected causative role of gadodiamide used for contrast-en- hanced magnetic resonance imaging. J Am Soc Nephrol 2006; 17:2359-2362. [CrossRef] Aydingöz U. The need for radiologists' aware- ness of nephrogenic systemic fibrosis. Diagn Interv Radiol 2006; 12:161-162.
2. Martin DR, Krishnamoorthy SK, Kalb B, et al. Decreased incidence of NSF in patients on dialysis after changing gadolinium contrast-en- hanced MRI protocols. J Magn Reson Imaging 2010; 31:440-446. [CrossRef] Kanal E, Tweedle MF. Residual or retained gadolinium: practical implications for radiol- ogists and our patients. Radiology 2015; 275:630-634. [CrossRef] Kanda T, Ishii K, Kawaguchi H, Kitajima K, Tak- enaka D. High signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted MR images: relationship with increasing cumulative dose of a gadolini- um-based contrast material. Radiology 2014; 270:834-841. [CrossRef] Errante Y, Cirimele V, Mallio CA, Di Lazzaro V, Zobel BB, Quattrocchi CC. Progressive increase of T1 signal intensity of the dentate nucleus on unenhanced magnetic resonance images is asso- ciated with cumulative doses of intravenously administered gadodiamide in patients with nor- mal renal function, suggesting dechelation. Invest Radiol 2014; 49:685-690. [CrossRef] Kanda, T, Fukusato T, Matsuda M, et al. Gad- olinium-based contrast agent accumulates in the brain even in subjects without severe renal dysfunction: evaluation of autopsy brain spec- imens with inductively coupled plasma mass spectroscopy. Radiology 2015; 276:228-232. [CrossRef] McDonald RJ, McDonald JS, Kallmes DF, et al. Intracranial gadolinium deposition after con- trast-enhanced MR imaging. Radiology 2015; 275:772-782. [CrossRef] Kanda, T, Osawa M, Oba H, et al. High signal intensity in dentate nucleus on unenhanced T1-weighted MR images: association with linear versus macrocyclic gadolinium chelate administra- tion. Radiology 2015; 275: 803-809. [CrossRef] Radbruch A, Weberling LD, Pascal J, et al. Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 2015; 275:78