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Journals / Cukurova Medical Journal / 2015 / Cilt: 40 - Sayı: 3

Agranulocytosis after Metamizole Sodium Use

Metamizol Sodyum Kullanımına Bağlı Agranülositoz

Eren ÇAĞAN
Havva ÇAĞAN
Duygu SÜRMELİHİNDİ
Pages
580–583
Publication Date
2015-09-30
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Here we present a case of a three-years- four- months-old girl who developed life-threatening agranulocytosis in his bone marrow after metamizole sodium use for fever, which resolved with granulocyte colony-stimulating factor therapy.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Metamizole sodium (Novalgine) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world and our country; however, it is banned in developed countries because of severe side effects.
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Key Findings & Data:Metamizole sodium (Novalgine) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world and our country; however, it is banned in developed countries because of severe side effects.
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Conclusion & Impact:Here we present a case of a three-years- four- months-old girl who developed life-threatening agranulocytosis in his bone marrow after metamizole sodium use for fever, which resolved with granulocyte colony-stimulating factor therapy.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Anahtar Kelimeler Agranülositoz · Metamizol · Çocuk

Abstract

Metamizole sodium (Novalgine) is commonly used as an antipyretic, analgesic, and spasmolytic agent in some parts of the world and our country; however, it is banned in developed countries because of severe side effects. Here we present a case of a three-years- four- months-old girl who developed life-threatening agranulocytosis in his bone marrow after metamizole sodium use for fever, which resolved with granulocyte colony-stimulating factor therapy.

Özet

Metamizol sodyum (Novalgine) ülkemizde ve dünyanın birçok yerinde antipiretik, aneljezik ve spazmolik olarak yaygın olarak kullanılmaktadır. Ancak gelişmiş ülkelerde şiddetli yan etkilerinden dolayı kullanılmamaktadır. Bu yazıda ateş nedeni ile metamizol sodyum kullanılan ve metamizol sodyum sonrasında kemik iliğinde agranülositoz gelişen ve granülosit koloni-uyarıcı faktör ile tedavi edilen üç yaş dört aylık bir kız hasta sunulmuştur.

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Cite This Article

ÇAĞAN, E., ÇAĞAN, H., SÜRMELİHİNDİ, D. (2015). Agranulocytosis after Metamizole Sodium Use. Cukurova Medical Journal, Cilt: 40 - Sayı: 3, 580–583. https://ajindex.com/articles/213518

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References (14)

  1. Ramacciotti AS, Soares BG, Atallah AN. Dipyrone for acute primary headaches. Cochrane Database Syst Rev. 2007;(2):CD004842
  2. Arellano F, Sacristan JA. Metamizole: reassessment of its therapeutic role. Eur J Clin Pharmacol. 1990;38:617-9
  3. Basak GW, Drozd-Sokolowska J, Wiktor-Jedrzejczak W. Update on the incidence of metamizole sodiuminduced blood dyscrasias in Poland. J Int Med Res. 2010;38:1374-80. 4. van der Klauw MM, Goudsmit R, Halie MR, van't Veer MB, Herings RM, Wilson JH, et al. A populationbased case-cohort study of drug-associated agranulocytosis. Arch Intern Med. 1999;159:369-74
  4. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65
  5. Kaufman DW, Kelly JP, Jurgelon JM, Anderson T, Issaragrisil S, Wiholm BE, et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol Suppl. 1996;60:23-30
  6. Billekop K, Mosbech J. [Mortality from agranulocytosis in Denmark during the period 1958- 1972]. Ugeskr Laeger 1976;138:1697-9
  7. Wiholm BE, Emanuelsson S. Drug-related blood dyscrasias in a Swedish reporting system, 1985- 1994. Eur J Haematol Suppl. 1996;60:42-6
  8. Kaufman DW, Kelly JP, Issaragrisil S, Laporte JR, Anderson T, Levy M, et al. Relative incidence of agranulocytosis and aplastic anemia. Am J Hematol. 2006;81:65-7
  9. Kaufman DW, Kelly JP, Jurgelon JM, Anderson T, Issaragrisil S, Wiholm BE, et al. Drugs in the aetiology of agranulocytosis and aplastic anaemia. Eur J Haematol Suppl. 1996;60:23-30
  10. Andersohn F, Konzen C, Garbe E. Systematic review: agranulocytosis induced by nonchemotherapy drugs. Ann Intern Med. 2007;146:657-65
  11. Andres E, Maloisel F, Zimmer J. The role of haematopoietic growth factors granulocyte colonystimulating factor and granulocyte-macrophage colony-stimulating factor in the management of druginduced agranulocytosis. Br J Haematol. 2010;150:3- 8
  12. Thomas D Coates.UpToDate_2014. Drug-induced neutropenia and agranulocytosis. Topic 8374 Version 20.0Topic 8374 Version 20.0. Jennifer S Tirnauer, editor. 7-4-2014. Ref Type: Online Source
  13. Hedenmalm K, Spigset O. Agranulocytosis and other blood dyscrasias associated with dipyrone (metamizole). Eur J Clin Pharmacol. 2002;58:265-74
  14. Tajiri J, Noguchi S, Murakami N. Usefulness of granulocyte count measurement four hours after injection of granulocyte colony-stimulating factor for detecting recovery from antithyroid drug-induced granulocytopenia. Thyro