SavedAdd your journal

Journals / Turkish Journal of Medical Sciences / 2014 / Cilt: 44 - Sayı: 6

Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women

İkbal KAYGUSUZ
Serap Aynur SİMAVLI
Ayla ESER
İlknur İNEGÖL GÜMÜŞ
Pages
980–984
Publication Date
2014-06-01
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease.
📊
Key Findings & Data:Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months.
💡
Conclusion & Impact:Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mean platelet volume · menopause · cardiovascular risk

Abstract

To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

Özet

To examine the effects of hormone replacement therapy (HRT) on mean platelet volume (MPV), lipid profile, and C-reactive protein (CRP) levels in postmenopausal women who have a high risk and incidence of cardiovascular disease. Materials and methods: This study was performed retrospectively. Twenty-seven healthy postmenopausal women received 1 mg estradiol and 2 mg drospirenone orally for 6 months. Twenty-eight healthy postmenopausal women not taking any HRT were admitted to the study as the control population. Results: Time effect (independent from group effect) was statistically significant for the MPV variable (P = 0.025), but there was no significant change in MPV levels and other cardiovascular disease risk markers in women receiving HRT compared to women in the control group. Conclusion: Younger postmenopausal women taking HRT and women who initiated hormone therapy close to menopause are not at increased risk of cardiovascular disease.

🔖

Cite This Article

KAYGUSUZ, İ., SİMAVLI, S. A., ESER, A., GÜMÜŞ, İ. İ. (2014). Effects of oral hormone replacement therapy on mean platelet volume in postmenopausal women. Turkish Journal of Medical Sciences, Cilt: 44 - Sayı: 6, 980–984. https://ajindex.com/articles/212937

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (12)

  1. Kaygusuz I, Turhan NO, Duvan CI, Koca C, Aydin M. Effect of genistein therapy on plasma levels of asymmetric dimethylarginine in healthy postmenopausal women: a randomized, placebo-controlled study. Fertil Steril 2010; 94: 764–766.
  2. Manson JE, Hsia J, Johnson KC, Rossouw JE, Assaf AR, Lasser NL, Trevisan M, Black HR, Heckbert SR, Detrano R et al. Women’s Health Initiative Investigators. Estrogen plus progestin and the risk of coronary heart disease. N Engl J Med 2003; 349: 523–534.
  3. Tavil Y, Sen N, Yazıcı HU, Hızal F, Abacı A, Cengel A. Mean platelet volume in patients with metabolic syndrome and its relationship with coronary artery disease. Thromb Res 2007; 120: 245–250.
  4. Ranganath LR, Christofides J, Semple MJ. Increased mean platelet volume after oestrogen replacement therapy. Ann Clin Biochem 1996; 33: 555–560.
  5. Teede HJ, McGrath BP, Turner A, Majewski H. Effects of oral combined hormone replacement therapy on platelet aggregation in postmenopausal women. Clin Sci 2001; 100: 207–213.
  6. Sumino H, Ichikawa S, Kasama S, Takahashi T, Kumakura H, Takayama Y, Kanda T, Kurabayashi M. Different effects of oral conjugated estrogen and transdermal estradiol on arterial stiffness and vascular inflammatory markers in postmenopausal women. Atherosclerosis 2006; 189: 436–442.
  7. Tarantino MD, Kunicki TJ, Nugent DJ. The estrogen receptor is present in human megakaryocytes. Ann N Y Acad Sci 1994; 714: 293–296.
  8. Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka- Karna J, Radziwon P, Lipska A. Platelet count, mean platelet volume and thrombocytopoietic indices in healthy women and men. Thromb Res 2006; 118: 199–204. Bain BJ. Platelet count and platelet size in males and females. Scand J Haematol 1985; 35: 77–79.
  9. Bessman JD, Williams LJ, Gilmer PR Jr. Mean platelet volume. The inverse relation of platelet size and count in normal subjects, and an artifact of other particles. Am J Clin Pathol 1981; 76: 289–293.
  10. Butkiewicz AM, Kemona H, Dymicka-Piekarska V, Matowicka- Karna J. Does menopause affect thrombocytopoiesis and platelet activation? Przegl Lek 2006; 63: 1291–1293.
  11. Saraç F, Saydam G, Sahin F, Öztekin K, Saygılı F, Tüzün M, Yılmaz C. Effects of hormone replacement therapy on insulin resistance and platelet function tests. Med Princ Pract 2009; 18: 43–47.
  12. Yoshimura T, Ohshige A, Maeda T, Ito M, Okamura H. Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women. Maturitas 1999; 31: 249–253.