Acute effect of hemodialysis on arterial elasticity

Objective & Hypothesis:Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD).

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Key Findings & Data:Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled.

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Conclusion & Impact:Conclusion: We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Arterial elasticity · hemodialysis · applanation tonometry

Abstract

Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD. Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations. Results: At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 ± 2.6 mL/mmHg × 100) than in healthy individuals (8.9 ± 3.4 mL/mmHg × 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 ± 2.6 mL/mmHg × 100 to 3.4 ± 2.3, P < 0.05). Conclusion: We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.

Özet

Reduced arterial elasticity is an independent predictor of cardiovascular mortality in patients with end-stage renal disease (ESRD). Hemodialysis (HD) treatment per se can bring additional risk factors for vascular disease. Our study was designed to determine whether a single hemodialysis session leads to an acute alteration in parameters of arterial elasticity in ESRD. Materials and methods: In this study, 58 patients undergoing chronic hemodialysis and 29 healthy controls were enrolled. Large artery elasticity index (LAEI) and the small artery elasticity index (SAEI) were measured by applanation tonometry. The acute effect of a hemodialysis session on arterial elasticity indices was assessed by comparison of prehemodialysis and posthemodialysis determinations. Results: At baseline, LAEI did not differ significantly in patients compared with controls. In contrast, the SAEI was significantly lower in patients (4.1 ± 2.6 mL/mmHg × 100) than in healthy individuals (8.9 ± 3.4 mL/mmHg × 100, P < 0.05). In patients with ESRD, no significant changes in LAEI was observed after HD, but SAEI deteriorated significantly (from 4.1 ± 2.6 mL/mmHg × 100 to 3.4 ± 2.3, P < 0.05). Conclusion: We conclude that ESRD patients face a significant reduction in SAEI, which is exacerbated by a dialysis procedure.

Keywords

Arterial elasticity hemodialysis applanation tonometry

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Cite This Article

SAĞ, S., YEŞİLBURSA, D., YILDIZ, A., DİLEK, K., ŞENTÜRK, T., SERDAR, O. A., AYDINLAR, A. (2015). Acute effect of hemodialysis on arterial elasticity. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 1, 246–250. https://ajindex.com/articles/212926

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