In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medium yields (20%-40%) from the reactions of le-g with 2a and 1e-h with 2c, respectively.
📌 3 Key Takeaways
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Objective & Hypothesis:The aim of this study is to synthesize novel piperazine-containing dihydrofuran compounds (3a-n)from radical additions and cyclizations of diacyl and alkyl-acyl piperazine derivatives (1a-h) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)(3) for the first time.
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Key Findings & Data:From the reactions of 1a-c with dimedone (2a);1a, 1c, and 1d with acetylacetone (2b); and la with ethylacetoacetate(2c) ,the dihydrofuran-piperazine compounds 3a-c > 3d-f, and 3g were obtained in medium to high yields (31%-81%), respectively.
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Conclusion & Impact:In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medium yields (20%-40%) from the reactions of le-g with 2a and 1e-h with 2c, respectively.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Piperazine · dihydrofuran · Mn(OAc)3
Abstract
The aim of this study is to synthesize novel piperazine-containing dihydrofuran compounds (3a-n)from radical additions and cyclizations of diacyl and alkyl-acyl piperazine derivatives (1a-h) with 1,3-dicarbonyl compounds (2a-c) mediated by Mn(OAc)(3) for the first time. From the reactions of 1a-c with dimedone (2a);1a, 1c, and 1d with acetylacetone (2b); and la with ethylacetoacetate(2c) ,the dihydrofuran-piperazine compounds 3a-c > 3d-f, and 3g were obtained in medium to high yields (31%-81%), respectively. In addition, dihydrofuran-piperazine compounds 3h-j and 3k-n were prepared at low to medium yields (20%-40%) from the reactions of le-g with 2a and 1e-h with 2c, respectively.
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