Journals / Ege Tıp Dergisi / 2014 / Cilt: 53 - Sayı: 4

A case of secondary intracranial hypertension resulted from isotretinoin use

İzotretinoin kullanımına bağlı gelişen sekonder intrakraniyal hipertansiyon olgusu

Pages
215–217
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Secondary IH should be kept in mind when using these drugs particularly in young female patients for they already have a susceptibility to develop this condition.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Idiopathic intracranial hypertension (IH) is characterized by headache and visual disturbance without any identified secondary cause.
📊
Key Findings & Data:On admission she had a CSF pressure of 81cm H2O and near total concentric contraction of both visual fields.
💡
Conclusion & Impact:Secondary IH should be kept in mind when using these drugs particularly in young female patients for they already have a susceptibility to develop this condition.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Idiopathic intracranial hypertension (IH) is characterized by headache and visual disturbance without any identified secondary cause. When potential contributing causes are detected, it is better that the term secondary IH be adopted. Presented below is a case of secondary IH caused by retinoids in which reversal to a great degree was observed a few weeks after cessation of the drug and with proper treatment. A twenty year old female patient was admitted with headache, nausea and blurred vision. She had been on isotretinoin therapy for six months prior to her admission. Although she stopped retinoid use and was started with low dose acetazolamide at an outside institution several days before, she did not show any improvement. On admission she had a CSF pressure of 81cm H2O and near total concentric contraction of both visual fields. With serial lumbar punctures and higher dose acetazolamide, her symptoms began to improve within several days. Her visual fields improved to a great degree at discharge. Tetracyclines, steroids and retinoids are relatively frequently used in dermatological practice. Secondary IH should be kept in mind when using these drugs particularly in young female patients for they already have a susceptibility to develop this condition.

Özet

İdiyopatik intrakraniyal hipertansiyon (İH) sekonder bir neden belirlenmeksizin ortaya çıkan baş ağrısı ve görme bozukluğu olarak tanımlanır. Buna yol açan potansiyel nedenler saptanmışsa sekonder İH teriminin kullanılması daha uygundur. Sunulan olguda retinoid kullanımına bağlı sekonder İH gelişmiş, ilacın kesilmesi ve uygun tedavi ile birkaç hafta sonra büyük oranda düzelme gözlenmiştir. Yirmi yaşında kadın hasta baş ağrısı, bulantı ve bulanık görme yakınmalarıyla başvurdu. Başvurudan önceki altı ay boyunca izotretinoin tedavisi almaktaydı. Birkaç gün önce bir dış merkezde retinoid tedavisi bırakılarak düşük doz asetazolamid başlanmasına rağmen hiç düzelme olmamıştı. Başvurduğunda BOS basıncı 81cm H2O idi ve her iki görme alanında tama yakın konsantrik daralma vardı. Tekrarlayan lomber ponksiyonlar ve daha yüksek doz asetazolamid ile günler içinde semptomları düzeldi. Taburcu olduğunda görme alanları büyük oranda düzelmişti. Tetrasiklin, steroid ve retinoidler dermatoloji pratiğinde nispeten sık kullanılırlar. Bu ilaçların özellikle genç kadın hastalarda kullanımı sırasında sekonder İH zaten yatkınlık taşımaları nedeniyle akılda tutulmalıdır.

🔖

Cite This Article

APAYDIN, E. D., GENÇ, E., DEMİR, Ö., ERUYAR, E. (2014). A case of secondary intracranial hypertension resulted from isotretinoin use. Ege Tıp Dergisi, Cilt: 53 - Sayı: 4, 215–217. https://ajindex.com/articles/211696

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (11)

  1. Friedman DI. Medication induced intracranial hypertension in dermatology. Am J Clin Dermatol 2005;6(1):29-37
  2. Binder DK, Horton JC, Lawton MT, et al. Idiopathic intracranial hypertension. Neurosurgery 2004;54:538-52
  3. Lee AG. Pseudotumor cerebri after treatment with tetracycline and isotretinoin for acne. Cutis1995 Mar;55(3):165-8
  4. Roytman M, Frumkin A, Bohn TG. Pseudotumor cerebri caused by isotretinoin. Cutis 1988;42(5):399-400
  5. Fishman R. Polar bear liver, vitamin A, aquaporins and pseudotumor cerebri. Ann Neurol 2002;52(5):531-3
  6. Jacobson DM, Berg R, Wall M, et al. Serum vitamin A concentration is elevated in idiopathic intracranial hypertension. Neurology 1999;53(5):1114-8
  7. SelhorstJB, Kulkantrakorn K, Corbett JJ, et al. Retinol binding protein in idiopathic intracranial hypertension. J Neuroophthalmol 2000;20(4):250-2 8. Warner JE, Bernstein PS, Yemelyanov A, et al. Vitamin A in the cerebrospinal fluid of patients with and without idiopathic intracranial hypertension. Ann Neurol 2002;52(5):647-50
  8. Tabassi A, Salmasi AH, Jalali M. Serum and CSF vitamin A concentrations in idiopathic intracranial hypertension. Neurology 2005;64(11):1893-6
  9. Warner JE, Larson AJ, Bhosale P, et al. Retinol binding protein and retinol analysis in cerebrospinal fluid and serum of patients with and without idiopathic intracranial hypertension. J Neuroopthalmol 2007;27(4):258-62
  10. Çıkım AÇ, Seyhan M. Akne vulgaris tedavisinde izotretinoinin etkinliği ve yan etkileri. Türkderm 2008;42(1):51-5
  11. Karadağ AS, Çalka Ö, Akdeniz N. İzotretinoin kullanan 150 akne vulgaris hastasında yan etkilerin değerlendirilmesi. Türkderm 2011;45(1):37-42.