Nowadays, while the effects of general anesthesia on central nervous system is not considered to be an important problem on healthy young adults, alongside many experiments on animals, few but significant clinical studies strengthenthe suspicion of anesthetic toxicity on the central nervous system in early or late ages
📌 3 Key Takeaways
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Objective & Hypothesis:Nowadays, while the effects of general anesthesia on central nervous system is not considered to be an important problem on healthy young adults, alongside many experiments on animals, few but significant clinical studies strengthenthe suspicion of anesthetic toxicity on the central nervous system in early or late ages
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Key Findings & Data:Nowadays, while the effects of general anesthesia on central nervous system is not considered to be an important problem on healthy young adults, alongside many experiments on animals, few but significant clinical studies strengthenthe suspicion of anesthetic toxicity on the central nervous system in early or late ages
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Conclusion & Impact:Nowadays, while the effects of general anesthesia on central nervous system is not considered to be an important problem on healthy young adults, alongside many experiments on animals, few but significant clinical studies strengthenthe suspicion of anesthetic toxicity on the central nervous system in early or late ages
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Nowadays, while the effects of general anesthesia on central nervous system is not considered to be an important problem on healthy young adults, alongside many experiments on animals, few but significant clinical studies strengthenthe suspicion of anesthetic toxicity on the central nervous system in early or late ages
Özet
Günümüzde genel anestezinin santral sinir sistemine etkisi sağlıklı genç yetişkinlerde önemli bir sorun olarak karşımıza çıkmazken, yapılan bir çok hayvan deneyi yanında az ama önemli klinik çalışmalar, yaşamın erken veya geç dönemlerinde santral sinir sistemi üzerine anestezik toksisite kuşkusunu güçlendirmektedir.
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Cite This Article
DENİZ, M. N. (2019). Is General Anesthesia Harmful for the Central Nervous System?. Kocaeli Tıp Dergisi, Cilt: 8 - Sayı: 1, 60–66. https://ajindex.com/articles/211280
Jackson K. Psychiological preparation as a method of reducing emotional trauma of anesthesia in children. Anesthesiol 1951; 12:293–300. 2-Wells BA, Keats AS, Cooley DA. Increased tolerance to cerebral ischemia produced by general anesthesia during temporary carotid occlusion. Surgery 1963; 54;216–23. 3- Hoffman WE, Charbel FT, Edelman G, Ausman JI. Thiopental and desflurane treatment for brain protection. Neurosurgery 1998; 43:1050–3. 4-Pape M, Engelhard K, Eberspächer E et al The long-term effect of sevoflurane on neuronal cell damage and expression of apoptotic factors after cerebral ischemia and reperfusion in rats. Anesth Analg. 2006; 103:173–79. 5- Khatibi NH, Ma Q, Rolland W, Ostrowski R et al. Isoflurane posttreatment reduced brain injury after an intracerebral hemorrhagic stroke in mice. Anesth Analg 2011; 113:343–8. 6- Chen H Burris M, Fajilan A, Spagnoli F, Tang J, Zhang JH. Prolonged exposure to isoflurane ameliorates infarction severity in the rat pup model of neonatal hypoxia-ischemia. Transl. Stroke Res 2011; 2;382–90. 7- Li H, Yin J, Li L, Deng J, Zuo Z. Isoflurane postconditioning reduces ischemia-induced nuclear factor-κB activation and interleukin 1β production to provide neuroprotection in rats and mice. Neurobiol. Dis 2013; 54:216–24. 8- Yan J, Jiang H. Dual effects of ketamine: Neurotoxicity versus neuroprotection in anesthesia for the developing brain. J. Neurosurg. Anesthesiol 2014; 26:155–60. 9- Zheng S, Zuo Z. Isoflurane preconditioning induces neuroprotection against ischemia via activation of p38 mitogen-activated protein kinase. Mol Pharmacol 2004; 65:1172-80. 10- Zheng S, Zuo Z. Isoflurane preconditioning reduces Purkinje cell death in an in vitro model of rat cerebellar ischemia. Neuroscience 2003; 118(1):99- 106. 11- Kapinya KJ, Löwl D, Fütterer C et al. Tolerance Against Ischemic Neuronal Injury Can Be Induced by Volatile Anesthetics and Is Inducible NO Synthase Dependent. Stroke 2002; 33:1889-98. 12- McMurtrey RJ, Zuo Z. Isoflurane preconditioning and postconditioning in rat hippocampal neurons. Brain Res 2010; 1358:184-90. 13- Lee JJ, Li L, Jung H-H Zuo Z. Postconditioning with isoflurane reduced ischemiainduced brain injury in rats. Anesthesiol 2008; 108:1055-62. 14- Komuro H, Rakic P. Modulation of neuronal migration by NMDA receptors. Science. 1993; 260:95– 7. 15- Jevtovic-Todorovic V. General Anesthetics and Neurotoxicity: How Much Do We Know? Anesthesiol Clin 2016; 34(3):439-51 16-Frank NP, Lieb RW. Seeing the Light