NEUTROPENIA ASSOCIATED WITH SERTRALINE USE: A CASE REPORT

This case is worth reporting since it underlines the need for considering the increased risk of much more severe hematological side effects associated with SSRI use in the presence of comorbid diseases or use of multiple drug therapy.

📌 3 Key Takeaways

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Objective & Hypothesis:Selective serotonin reuptake inhibitors (SSRIs) are preferred over other antidepressant drugs due to their low anticholinergic and cardiotoxic side effects.

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Key Findings & Data:Although SSRIs are regarded as safe drugs, they may have some severe hematologic side effects.

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Conclusion & Impact:This case is worth reporting since it underlines the need for considering the increased risk of much more severe hematological side effects associated with SSRI use in the presence of comorbid diseases or use of multiple drug therapy.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Selective serotonin reuptake inhibitors (SSRIs) are preferred over other antidepressant drugs due to their low anticholinergic and cardiotoxic side effects. Although SSRIs are regarded as safe drugs, they may have some severe hematologic side effects. Neutropenia is one of the rare and transient side effects of antidepressant drugs. In this report, a case of sertraline induced neutropenia was aimed to be described. Although sertraline is a widely used antidepressant in children and adults, neutropenia induced by this drug is very rare. When all data were evaluated, since the case had no history of any medical illness that might have caused neutropenia and any relevant drug use, neutropenia was associated with sertraline use in the case presented. Thus, improvement of neutropenia after cessation of sertraline treatment further supported this opinion. This case is worth reporting since it underlines the need for considering the increased risk of much more severe hematological side effects associated with SSRI use in the presence of comorbid diseases or use of multiple drug therapy.

Özet

Seçici serotonin geri alım inhibitör (SSGİ) grubu antidepresanlar düşük antikolinerjik ve kardiyotoksik yan etkileri nedeniyle diğer antidepresan ilaçlara göre daha çok tercih edilen ilaçlardır. SSGİleri güvenli kabul edilmelerine karşın, bazen ciddi hematolojik yan etkilere neden olabilmektedirler. Nötropeni antidepresan kullanımının nadir ve geçici yan etkilerinden biridir. Bu yazıda sertralin kullanımına bağlı nötropeni gelişen bir olgunun sunulması amaçlanmıştır. Sertralin çocuk ve erişkinlerde yaygın olarak kullanılan bir antidepresan olmasına karşın, bu ilaca bağlı nötropeni nadirdir. Bu olguda eldeki veriler değerlendirildiğinde nötropeniye yol açabilecek başka bir hastalık öyküsünün ve ilaç kullanımının olmaması nedeniyle nötropeni tablosu sertralin kullanımı ile ilişkilendirilmiştir. Sertralin tedavisinin kesilmesinin ardından nötropeni tablosunun düzelmesi de bu kanaati destekler niteliktedir. Bu bulgu, başka bir hastalık varlığında yada çoklu ilaç kullanımında SSGİ kullanımının daha ciddi hematolojik yan etkilere yol açabilme riskinin göz önünde bulundurulması açısından değerlidir.

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Cite This Article

GÜNEY, T., SÖNMEZ, C. I., GÜNEY, E., BAKANAY, Ş. M. Ö., GÖKER, Z., BAŞTÜRK, A., AKINCI, S., HACIBEKİROGLU, T., DİLEK, İ. (2012). NEUTROPENIA ASSOCIATED WITH SERTRALINE USE: A CASE REPORT. Çocuk ve Gençlik Ruh Sağlığı Dergisi, Cilt: 19 - Sayı: 1, 43–46. https://ajindex.com/articles/210771

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