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Journals / Cyprus Journal of Medical Sciences / 2020 / Cilt: 5 - Sayı: 4

Calcium and Sodium Channel Blockers and Gastrointestinal Motility

Emine KOÇ
Pages
295–298
DOI
—
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

CONCLUSION Calcium and sodium channel blockers have significantly decreasedgastrointestinal motility.

📌 3 Key Takeaways

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Objective & Hypothesis:BACKGROUND/AIMS Calcium and sodium channels are necessary in all excitable cells to maintain their functions.
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Key Findings & Data:To study the effects of calciumchannel blocker nifedipine (1,4-dihidropyridine calcium channel blocker) and sodiumchannel blocker prilocaine [2-(propylamino)-o-propionotoluidide], ileal segments were incubated with these agents, and ACh-induced contractions were then recorded.
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Conclusion & Impact:CONCLUSION Calcium and sodium channel blockers have significantly decreasedgastrointestinal motility.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

BACKGROUND/AIMS Calcium and sodium channels are necessary in all excitable cells to maintain their functions. Calciumchannel blockers are generally used clinically to treat various pathological conditions such as cardiovascular diseases. Moreover, sodium channel blockers are widely used clinically, such as in dentistry. Given their widespread use, these blockers may have effects on gastrointestinal motility. MATERIAL and METHODS This study used healthy adult Wistar rats for the experiments. The ileal segments were isolated and suspended in tissuebath. Contractile responses induced by acetylcholine (ACh) were recorded. To study the effects of calciumchannel blocker nifedipine (1,4-dihidropyridine calcium channel blocker) and sodiumchannel blocker prilocaine [2-(propylamino)-o-propionotoluidide], ileal segments were incubated with these agents, and ACh-induced contractions were then recorded. RESULTS All doses of calcium and sodium channel blockers significantly decreased the ACh-induced contractions in isolated ileal segments. CONCLUSION Calcium and sodium channel blockers have significantly decreasedgastrointestinal motility.

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Cite This Article

KOÇ, E. (2020). Calcium and Sodium Channel Blockers and Gastrointestinal Motility. Cyprus Journal of Medical Sciences, Cilt: 5 - Sayı: 4, 295–298. https://ajindex.com/articles/210205

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References (13)

  1. Guemes M, Shah P, Silvera S, Morgan K, Gilbert C, Hinchey L, et al. Assesment of nifedipine therapy in hyperinsulinemic hypoglycemia due to mutations in the ABCC8 gene. J Clin Endocrinol Metab 2017 Mar
  2. 102(3): 822-30. [Crossref] 2. Rubini A, Catena V, del Monte D, Bosco G. The effects of nifedipine on respiratory mechanics investigated by the end-inflation occlusion method in the rat. J Enzyme Inhib Med Chem 2017
  3. 32(1): 1-4. [Crossref] 3. Singh A, Verma P, Balaji G, Samantar S, Mohanakuma KP. Nimodipine, an L-type calcium channel blocker attenuates mitochondrial dysfunctions to protect against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine- induced Parkinsonism in mice. Neurochem Int 2016
  4. [Crossref] 4. Ye R, Liu J, Jia ZY, Wang H, Wang YA, Sun W, et al. Adenosine trifosphate inhibits voltage-sensetive potassium currents in Isolated hensen’s Cell and Nifedipine Protects Against Noise-Induced Hearing Loss in Guinea Pigs. Med Sci Monit 2016
  5. [Crossref] 5. Muroi Y, Chanda B. Local anesthetic distrupt energetic coupling between the voltage-sensing segments of a sodium channel. J Gen Physiol 2009
  6. 133(1): 1-15. [Crossref] 6. Lee S, Goodchild SJ, Samuel J, Ahern CA. Local anesthetic inhibition of a bacterial sodium channel. J Gen Physiol 2012
  7. 139(6): 507-16. [Crossref] 7. Brau ME, Nau C, Hempelman G, Vogel W. Local anesthetics potently block a potential insensitive potassium Channel in myelinated nerve. J Gen Physiol 2012
  8. 139(6): 507-16. [Crossref] 8. Wang GK, Mok WM, Wang SY. Changed tetracaine as an inactivation enhancer in batrachotoxin-modified Na channels. Biophys J 1994
  9. [Crossref] 9. Tsuda Y, Mashimo T, Yoshiya I, iKaseda K, Harada Y, Yanagida T. Direct inhibition of the actomyosin motility by local anesthetics in vitro. Biophys J 1996
  10. [Crossref] 10. Godfraind T. Calcium Channel Blockers in cardiovascular Pharmacotherapy. J Cardiovasc Pharmacol Ther 2014
  11. 19(6): 501-15. [Crossref] 11. Patai Z, Guttman A, Mikus EG. Potential L-type Voltage-Operated Calcium Channel Blocking Effect of Drotaverine on Functional Models. J Pharmacol Exp Ther 2016
  12. 359(3): 442-51. [Crossref] 12. Dorkkan N, Vongdee K, Sunttomsaratoon P, Krishnamra N, Charoenphandhu H. Prolactin stimulates the calcium channel-mediated transepitelhelial calcium transport in the duodenum of male rats. Biochem Biophys Res Commun 2013
  13. 430(2): 711-6. [Crossref] 13. Bladen C, Gündüz MG, Şimşek R, Safak R, Zampon GW. Synthesis and Evaluation of