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Journals / Haseki Tıp Bülteni / 2016 / Cilt: 54 - Sayı: 1

Is There a Relationship Between 25-Hydroksyvitamin D3 Levels and Diabetes Control?

25-Hidroksivitamin D3 Düzeyleri Diyabetin Kontrolü ile İlişkili midir?

Maide Hacer TEKİN
Osman EVLİYAOĞLU
SEMBOL YILDIRMAK
Okan DİKKER
FATMA TEZCAN
Pages
36–40
DOI
—
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion:­ In addition to HbA1c levels, 25-hydroxyvitamin D levels should be investigated and considered especially in follow-up of diabetic female patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim:­ The aim of this study was to evaluate the relationship between hemoglobin A1c (HbA1c) and 25-hydroxyvitamin D levels and to investigate the difference in this relationship between genders.
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Key Findings & Data:Methods:­In this study, we retrospectively evaluated fasting blood glucose, HbA1c, 25-hydroxyvitamin D and parathyroid hormone levels in 3675 subjects (660 male, 3015 female).
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Conclusion & Impact:Conclusion:­ In addition to HbA1c levels, 25-hydroxyvitamin D levels should be investigated and considered especially in follow-up of diabetic female patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim:­ The aim of this study was to evaluate the relationship between hemoglobin A1c (HbA1c) and 25-hydroxyvitamin D levels and to investigate the difference in this relationship between genders. Methods:­In this study, we retrospectively evaluated fasting blood glucose, HbA1c, 25-hydroxyvitamin D and parathyroid hormone levels in 3675 subjects (660 male, 3015 female). The subjects were divided into two groups according to sex and into three groups according to HbA1c levels as pre-diabetics (5.7-6.4%), diabetics (6.5-8.0%) and uncontrolled diabetics (>8.1%). Individuals with an HbA1c value between 4.0% and 5.6% who had no history of diabetes mellitus constituted the control group. Results:­ Significantly low levels of 25-hydroxyvitamin D were detected in female uncontrolled diabetics (p<0.001). However, no difference found in males between the groups A downward trend in 25-hydroxyvitamin D levels was observed to start in prediabetes period. There was no significant difference in parathyroid hormone levels between the groups. Conclusion:­ In addition to HbA1c levels, 25-hydroxyvitamin D levels should be investigated and considered especially in follow-up of diabetic female patients.

Özet

Amaç:­Çalışmamız hemoglobin A1c (HbA1c) ile serum 25-hidroksi vitamin düzeyleri arasındaki ilişkiyi incelemek ve cinsiyete bağlı olası farklılıkları araştırmak için planlandı.Yöntemler:­Bu çalışmada 660 erkek, 3015 kadın olmak üzere toplam 3675 kişinin açlık kan glukozu, HbA1c, parathormon ve 25-hidroksi vitamin D değerleri retrospektif olarak incelendi. Çalışmamıza dahil edilen kişiler cinsiyetlerine göre iki, HbA1c düzeylerine göre; prediyabetli, diyabetli ve kontrolsüz diyabetli olarak üç gruba ayrıldı (HbA1c düzeyleri sırasıyla, %5,7-6,4, %6,5-8,0 ve >%8,1). Diyabet öyküsü olmayan ve HbA1c düzeyleri %4,0-5,6 olan bireyler kontrol grubunu oluşturdu.Bulgular:­Kontrolsüz diyabetli kadın hasta grubunda 25-hidroksi vitamin D düzeyleri anlamlı düşük saptanırken (p<0,001), erkeklerde hiçbir grupta fark gözlenmedi. Kadınlardaki 25-hidroksi vitamin D düzeylerindeki düşme eğiliminin prediyabet dönem olan HbA1c değeri %5,8'de başladığı gözlendi. Parathormon düzeyleri açısından gruplar arasında anlamlı bir fark bulunmadı.Sonuç:­HbA1c'nin yanı sıra 25-hidroksi vitamin D düzeylerinin de araştırılması özellikle diyabetli kadın hastaların izleminde dikkate alınmalıdır.Anahtar­ Sözcükler:­ Diyabet, Hemoglobin A1c, 25-hidroksi vitamin D, parathormon.

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Cite This Article

TEKİN, M. H., EVLİYAOĞLU, O., YILDIRMAK, S., DİKKER, O., TEZCAN, F. (2016). Is There a Relationship Between 25-Hydroksyvitamin D3 Levels and Diabetes Control?. Haseki Tıp Bülteni, Cilt: 54 - Sayı: 1, 36–40. https://ajindex.com/articles/209714

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