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Journals / Turkish Journal of Medical Sciences / 2015 / Cilt: 45 - Sayı: 1

Structural chromosomal abnormalities in couples with recurrent abortion in Egypt

Nagwa E.a. GABOON
Ahmed Ramy MOHAMED
Solaf M. ELSAYED
Osama K. ZAKI
Mohamed A. ELSAYED
Pages
208–213
Publication Date
2015-03-15
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Couples who experience => 2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis.
📊
Key Findings & Data:Materials and methods: The present study examined 125 couples who had experienced recurrent abortion.
💡
Conclusion & Impact:Conclusion: Couples who experience => 2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Recurrent abortion · chromosomal abnormality · balanced carrier

Abstract

To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis. Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed a reciprocal translocation and 1 (0.8%) showed a Robertsonian translocation. All carriers of these translocations were aged < 35 years. A significant proportion of carriers reported a poor obstetric history and a past fetal malformation. All male carriers had a normal semen analysis. Conclusion: Couples who experience => 2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.

Özet

To evaluate the incidence of chromosomal abnormalities in couples who experience recurrent abortion and identify additional factors that may be predictive of abortion, such as parental age and unfavorable obstetric or abnormal semen analysis. Materials and methods: The present study examined 125 couples who had experienced recurrent abortion. All subjects provided a detailed personal medical history and ancestral history and underwent a physical examination. Women in the study group underwent biochemical testing and pelvic ultrasound examinations, and men underwent a semen analysis. Results: Among the 125 couples tested, 8 couples (6.4%) displayed a balanced translocation, among which 7 (5.6%) showed a reciprocal translocation and 1 (0.8%) showed a Robertsonian translocation. All carriers of these translocations were aged < 35 years. A significant proportion of carriers reported a poor obstetric history and a past fetal malformation. All male carriers had a normal semen analysis. Conclusion: Couples who experience => 2 pregnancy losses of unknown origin should undergo a cytogenetic analysis, and findings showing a chromosomal abnormality in either parent must be followed by genetic counseling.

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Cite This Article

GABOON, N. E., MOHAMED, A. R., ELSAYED, S. M., ZAKI, O. K., ELSAYED, M. A. (2015). Structural chromosomal abnormalities in couples with recurrent abortion in Egypt. Turkish Journal of Medical Sciences, Cilt: 45 - Sayı: 1, 208–213. https://ajindex.com/articles/209670

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