Journals / Kırıkkale Üniversitesi Tıp Fakültesi Dergisi / 2019 / Cilt: 21 - Sayı: 2

Correlation and Assessment of Cost-Effectivity of Simultaneous PCT and CRP Measurements for Patients with Community-Acquired Pneumonia and COPD Inflamation

EŞ ZAMANLI PCT VE CRP İSTENEN TOPLUM KÖKENLİ PNÖMONİ VE KOAH ALEVLENMESİ OLAN HASTALARDA BU PARAMETRELERİN KORELASYONU VE MALİYET ETKİLİLİK AÇISINDAN DEĞERLENDİRİLMES

Pages
239–248
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Procalcitonine was found to be positively correlated to C-reactive protein and it was suggested that procalcitonine could be used instead of the costly C reactive protein during long-term infection care.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Bacterial infections are important causes of morbidity and mortality.
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Key Findings & Data:Serum procalcitonin and C-reactive protein are significant indicators during the diagnosis, treatment and follow-up of systemic inflammations and bacterial infections.
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Conclusion & Impact:Conclusion: Procalcitonine was found to be positively correlated to C-reactive protein and it was suggested that procalcitonine could be used instead of the costly C reactive protein during long-term infection care.
🔬Design:Research Article
📍Scope:4712 samples
⚙️Variables:Domain Parameters

Abstract

Objective: Bacterial infections are important causes of morbidity and mortality. Serum procalcitonin and C-reactive protein are significant indicators during the diagnosis, treatment and follow-up of systemic inflammations and bacterial infections. In this study, correlation between levels of procalcitonin, which has recently become commonly used in infection cases, and C-reactive protein, the conventional indicator, were investigated for patients whose final diagnoses were found as pneumonia and/or COPD inflammation. Additionally, the study aimed to determine which among the two indicators was cost-effective for the diagnosis and management of lower respiratory infections. Material and Methods: Procalcitonin and C-reactive protein results of 4712 samples, which were gathered from 1948 patients and measured simultaneously were assessed. Among the samples, 499 (10.6%) were from COPD inflammation patients (Group I), 1480 (31.4%) were from pneumonia patients (Group II), and the remaining 2733 (58%) were from COPD inflammation and pneumonia patients (Group III). Results: A strong positive correlation was detected between Creactive protein and procalcitonin levels (rho=0.512, p<0.001). As for the assessments within the established groups I, II and III, again a strong positive correlation was seen (rho=0.539, p<0.001; rho=0.509, p<0.001; rho=0.511, p<0.001, respectively). Conclusion: Procalcitonine was found to be positively correlated to C-reactive protein and it was suggested that procalcitonine could be used instead of the costly C reactive protein during long-term infection care.

Özet

Amaç: Bakteriyel enfeksiyonlar önemli morbidite ve mortalite nedenidir. Serum prokalsitonin ve C-reaktif protein sistemik inflamasyon ve bakteriyel enfeksiyonların tanı, tedavi ve takibinde önemli belirteçlerdir. Bu çalışmada nihai tanıları pnömoni ve/veya KOAH alevlenmesi olan hastalarda son zamanlarda enfeksiyon takibinde sıklıkla kullanılmaya başlanan prokalsitonin ile klasik belirteç olarak kullanılan C-reaktif protein düzeyleri arasındaki korelasyon araştırıldı. Ayrıca alt solunum yolu enfeksiyonu tanısı ya da yönetimi için C-reaktif proteinin mi, prokalsitoninin mi maliyet etkililik açısından yararlı olduğunu saptamayı amaçladık. Gereç ve Yöntemler: Toplam 1948 hastadan elde edilmiş 4712 örnekten eş zamanlı çalışılan prokalsitonin ve Creaktif protein sonuçları değerlendirildi. Örneklerden 499’u (%10.6) KOAH alevlenmesi (Grup I), 1480’i (%31.4) pnömoni (Grup II) ve 2733 (%58)’i KOAH alevlenmesi ve pnömoni (Grup III) tanısı almış hastaların örneklerinden oluşuyordu. Bulgular: C-reaktif protein ve prokalsitonin düzeyleri arasında pozitif güçlü korelasyon saptandı (rho=0.512, p<0.001). Yine prokalsitonin ve C-reaktif protein arasındaki grup içi değerlendirmede Grup I, Grup II ve Grup III’de pozitif güçlü korelasyon tespit edildi (sırasıyla rho=0.539, p<0.001; rho=0.509, p<0.001; rho=0.511, p<0.001). Sonuç: Prokalsitoninin C-reaktif protein ile korelasyon gösterdiği, enfeksiyonun ileri dönem takibinde yüksek maliyetli prokalsitonin yerine C-reaktif protein ölçümünün kullanılmasının uygun olacağı kanaatine varılmıştır

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Cite This Article

BADEM, N. D., PEKER, S. A., KAYGUSUZ, S. (2019). Correlation and Assessment of Cost-Effectivity of Simultaneous PCT and CRP Measurements for Patients with Community-Acquired Pneumonia and COPD Inflamation. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Cilt: 21 - Sayı: 2, 239–248. https://ajindex.com/articles/209468

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References (11)

  1. Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis. 2004;39(2):206-17
  2. Çolak A, Yılmaz C, Toprak B, Aktoğu S. Procalcitonin and CRP as biomarkers in discrimination of community-acquired pneumonia and exacerbation of COPD. J Med Biochem. 2017;36(2):122-26. Doi:10.1515/jomb-2017-0011
  3. Taşçı C, Deniz Ö, Tozkoparan E, Özkan M, Balkan A, Bilgiç H ve ark. Toplum kökenli pnömonilerde serum prokalsitonin değerleri ile diğer akut faz reaktanları ve hastalığın radyolojik yaygınlığı arasındaki ilişki. Toraks Dergisi. 2007;8(3):156-62
  4. Taşbakan MS, Gündüz C, Sayıner A, Çilli A, Çelenk Karaboğa B, Şakar Çoşkun A et al. Serum procalcitonin and C-reactive protein kinetics as indicators of treatment outcome in hospitalized patients with community-acquired pneumonia. Turk J Med Sci. 2016;46(5):1422-7. Doi:10.3906/sag1507-20
  5. Müller F, Christ-Crain, Bregenzer T, Krause M, Zimmerli W, Mueller B et al. Procalcitonin levels predict bacteremia in patients with communityacquired pneumonia. Chest. 2010;138(1):121-9. Doi:10.1378/chest.09-2920
  6. Özlü T, Bülbül Y, Alataş F, Arseven O, Şakar Coşkun A, Çilli A ve ark. Türk Toraks Derneği erişkinlerde toplumda gelişen pnömoni tanı ve tedavi uzlaşı raporu. Türk Toraks Dergisi. 2009;10(Supp 9):1-16
  7. Lacoma A, Prat C, Andreo F, Lores L, RuizManzano J, Ausina V et al. Value of procalcitonin, C-reactive protein, and neopterin in exacerbations of chronic obstructive pulmonary disease. International Journal of COPD. 2011;6:157-69. Doi:10.2147/COPD.S16070
  8. Sapey E, Stockley RA. COPD exacerbations 2: aetiology. Thorax. 2006;61(3):250-8
  9. Akcay I, Okoh AK, Yalav O, Eray IC, Rencuzogullari A, Dalci K et al. The prognostic value of pro-calcitonin, CRP and thyroid hormones in secondary peritonitis: a single-center prospective study. Ulus Travma Acil Cerrahi Derg. 2014;5(20):343-52. 10.Christ-Crain M, Opal SM. Clinical review: The role of biomarkers in the diagnosis and management of community-acquired pneumonia. Critical Care. 2010;203(14):1-11
  10. Harrison M, Collins CD. Is procalcitonin-guided antimicrobial use cost-effective in adult patients with suspected bacterial ınfection and sepsis? Infect Control Hosp Epidemiol. 2015;36(3):265-72
  11. Gyawali B, Ramakrishna K, Dhamoon AS. Sepsis: The evolution in definition, pathophysiology, and management. SAGE Open Medicine. 2019;7:20503