The Investigation of Protocadherin Gene Family Members PCDH8, PCDH10, and PCDH17 as Epigenetic Biomarkers in Blood Samples of Patients with Bladder Tumor
MESANE TÜMÖRLÜ HASTALARIN KANLARINDA EPİGENETİK BİYOBELİRTEÇLER OLARAK PROTOKADERİN GEN AİLESİ ÜYELERİ PCDH8, PCDH10 VE PCDH17’NİN ARAŞTIRILMASI
The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.
📌 3 Key Takeaways
🎯
Objective & Hypothesis:Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls.
📊
Key Findings & Data:Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls.
💡
Conclusion & Impact:The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Mesane kanseri · DNA metilasyonu · periferik kan
Abstract
Objective: The aim of the study was to evaluate the potential tumor-specific effects of peripheral blood DNA methylation profiles of protocadherin 8 (PCDH8), protocadherin 10 (PCDH10), and protocadherin 17 (PCDH17) genes who belong to the protocadherin gene family, in patients with bladder tumors and healthy controls. The potential association between methylation profiles of the investigated three genes and demographic and/or clinicopathologic data was a second target of the study.
Özet
Amaç: Çalışmanın amacı mesane tümörlü hastalarda ve sağlıklı kontrollerde protokaderin gen ailesine ait olan protokaderin 8 (PCDH8), protokaderin 10 (PCDH10) ve protokaderin 17 (PCDH17) genlerinin periferal kan DNA metilasyon profillerini analiz ederek bu profillerin tümör-spesifik olası etkilerini değerlendirmektir. Araştırılan üç genin metilasyon profiliyle spesifik demografik ve/veya klinikopatolojik veriler arasındaki olası ilişkinin araştırılması da çalışmanın ikinci hedefidir.
YEĞİN, Z., ÖZEN, F., KOÇ, H., YILDIRIM, A., BÜYÜKALPELLİ, R. (2020). The Investigation of Protocadherin Gene Family Members PCDH8, PCDH10, and PCDH17 as Epigenetic Biomarkers in Blood Samples of Patients with Bladder Tumor. Kırıkkale Üniversitesi Tıp Fakültesi Dergisi, Cilt: 22 - Sayı: 2, 163–171. https://ajindex.com/articles/209454
Lin YL, Ma JH, Luo XL, Guan TY, Li ZG. Clinical significance of protokaderin-8 (PCDH8) promotor methylation in bladder cancer. J Int Med Res. 2013;41(1):48-54
Luo ZG, Li ZG, Gui SL, Chi BJ, Ma JG. Protokaderin-17 promotor methylation in serum-derived DNA is associated with poor prognosis of bladder cancer. J Int Med Res. 2014;42(1):35-41
Zhang D, Zhao W, Liao X, Bi T, Li H, Che X. Frequent silencing of protokaderin 8 by promotor methylation, a candidate tumor suppressor for human gastric cancer. Oncol Rep. 2012;28(5):1785-91
Lin YL, Xie PG, Wang L, Ma JG. Aberrant methylation of protokaderin 17 and its clinical significance in patients with prostate cancer after radical prostatectomy. Med Sci Monit. 2014;20:1376-82
Kim SY, Yasuda S, Tanaka H, Yamagata K, Kim H. Non-clustered protokaderin. Cell Adh Migr. 2011;5(2):97-105
Danese E, Minicozzi AM, Benati M, Montagnana M, Paviati E, Salvagno GL et al. Epigenetic alteration: new insights moving from tissue to plasma- the example of PCDH10 promotor methylation in colorectal cancer. Br J Cancer. 2013;109(3):807-13
Qiu C, Bu X, Jiang Z. Protokaderin-10 acts as a tumor suppressor gene, and is frequently downregulated by promotor methylation in pancreatic cancer cells. Oncol Rep. 2016;36(1):383-9
Deng QK, Lei YG, Lin YL, Ma JG, Li WP. Prognostic value of protokaderin10 (PCDH10) methylation in serum of prostate cancer patients. Med Sci Monit. 2016;22:516-21
Lin YL, Li ZG, He ZK, Guan TY, Ma JG. Clinical and prognostic significance of protokaderin-10 (PCDH10) promotor methylation in bladder cancer. J Int Med Res. 2012;40(6):2117-23
Wang XB, Lin YL, Li ZG, Ma JH, Li J, Ma JG. Protokaderin 17 promotor methylation in tumour tissue from patients with bladder transitional cell carcinoma. J Int Med Res. 2014;42(2):292-9
Costa VL, Henrique R, Danielsen SA, Eknaes M, Patrício P, Morais A et al. TCF21 and PCDH17 methylation: An innovative panel of biomarkers for a simultaneous detection of urological cancers. Epigenetics. 2011;6(9):1120-30
Miotto E, Sabbioni S, Veronese A, Calin GA, Gullini S, Liboni A et al. Frequent aberrant methylation of the CDH4 gene promotor in human colorectal and gastric cancer. Cancer Res. 2004;64(22):8156-9
Hsiung DT, Marsit CJ, Houseman EA, Eddy K, Furniss CS, McClean MD et al. Global DNA Methylation Level in Whole Blood as a Biomarker in Head and Neck Squamous Cell Carcinoma. Cancer Epidemiol Biomarkers Prev. 2007;16(1)