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Journals / Kocaeli Tıp Dergisi / 2017 / Cilt: 6 - Sayı: 3

Clinical Significance of Repolarization Parameters in Brugada Syndrome Patients

Brugada Sendromu Hastalarında Repolarizasyon Parametrelerinin Klinik Önemi

KIVANÇ YALIN
Tümer Erdem GÜLER
TOLGA AKSU
Ebru GÖLCÜK
KAMİL ADALET
Pages
30–35
DOI
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AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Furthermore, during f/u all patients with ventricular arrhythmiashad Tp-e interval longer than 100 ms DISCUSSION and CONCLUSION: TWA is an inappropriate test for BS, prolonger Tpe may be related to increased risk in BS patients

📌 3 Key Takeaways

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Objective & Hypothesis:INTRODUCTION: Brugada syndrome (BS) is a genetic disease with increased risk of sudden cardiac death.
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Key Findings & Data:Increased T wave alternans (TWA) and prolonged T wave peak to end (Tp-e) interval are linked to sudden cardiac death.
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Conclusion & Impact:Furthermore, during f/u all patients with ventricular arrhythmiashad Tp-e interval longer than 100 ms DISCUSSION and CONCLUSION: TWA is an inappropriate test for BS, prolonger Tpe may be related to increased risk in BS patients
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

INTRODUCTION: Brugada syndrome (BS) is a genetic disease with increased risk of sudden cardiac death. Increased T wave alternans (TWA) and prolonged T wave peak to end (Tp-e) interval are linked to sudden cardiac death. In the present study, we investigated the role of TWA and Tp-e interval in BS. METHODS: Thirteen BS and 11 controls were included. TWA and ECG were recorded. Patients and controls were followed for ventricular arrhythmias. RESULTS: TWA study was negative in BS and controls. Tp-e interval was longer in BS than controls. Furthermore, during f/u all patients with ventricular arrhythmiashad Tp-e interval longer than 100 ms DISCUSSION and CONCLUSION: TWA is an inappropriate test for BS, prolonger Tpe may be related to increased risk in BS patients

Özet

GİRİŞ ve AMAÇ: Brugada Sendromu (BS) ani ölüm riskinin arttığı kalıtsal bir hastalıktır. Mevcut risk parametreleri yetersizdir. Artmış T dalga alternansı (TDA) ve uzamış T dalgası pik-son süresi (Tp-e) ani kardiyak ölüm ile ilişkilidir. Bu çalışmada TDA ve Tp-e süresinin BS hastalarındaki rolü araştırılmıştır YÖNTEM ve GEREÇLER: Çalışmaya 13 BS hastası ve 11 kontrol alınmıştır. BS ve kontrollerde TDA ve EKG kaydedilmiştir. Hastalar ve kontroler ventriküler aritmi açısından takip edilmiştir. BULGULAR: BS ve kontrollerde TDA negatif saptanmıştır. Ancak BS hastalarında Tp-e süresi kontrollere göre daha uzun saptanmıştır. Ayrıca takipte ventriküler aritmi gelişen hastaların tümünde Tp-e 100 ms' nin üzerindedir. TARTIŞMA ve SONUÇ: BS hastalarında TDA uygun olmayan bir testtir, Tp-e süresinin uzaması BS hastalarında artmış risk ile ilişkili olabilir.

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Cite This Article

YALIN, K., GÜLER, T. E., AKSU, T., GÖLCÜK, E., ADALET, K. (2017). Clinical Significance of Repolarization Parameters in Brugada Syndrome Patients. Kocaeli Tıp Dergisi, Cilt: 6 - Sayı: 3, 30–35. https://ajindex.com/articles/209272

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