Methionine restricted diet may hneave beneficial effects on serum/plasma total homocysteine levels of the patients with MTHFR enzyme polymorphisms.
📌 3 Key Takeaways
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Objective & Hypothesis:To review nutritional therapy of hyperhomocysteinemia observed in Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms.
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Key Findings & Data:The researches and review articles about the subject has been read, investigated, compiled and integrated with our clinical experience.
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Conclusion & Impact:Methionine restricted diet may hneave beneficial effects on serum/plasma total homocysteine levels of the patients with MTHFR enzyme polymorphisms.
🔬Design:Review & Systematic Survey
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
To review nutritional therapy of hyperhomocysteinemia observed in Methylenetetrahydrofolate Reductase (MTHFR) gene polymorphisms. The researches and review articles about the subject has been read, investigated, compiled and integrated with our clinical experience. In the therapy of MTHFR gene polymorphisms, nutritional therapy is an integral part of the therapy and methionine restricted diet should be encouraged with vitamin supplementation which have important functions in methionine-ho- mocysteine pathways. Methionine restricted diet may hneave beneficial effects on serum/plasma total homocysteine levels of the patients with MTHFR enzyme polymorphisms.
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Cite This Article
GÜNEBAK, Ç. T. Ş., ŞAHİN, N., BESLER, H. T., BEKSAÇ, M. S. (2012). Methionine restricted diet; Clinical application. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 18 - Sayı: 1, 54–61. https://ajindex.com/articles/208473
Stanger, O., et al., Clinical use and rational management of homocysteine, folic acid, and B vitamins in cardiovas- cular and thrombotic diseases. Z Kardiol 2004;93:439-53
Stanger, O., et al., DACH-LIGA homocystein (german, austrian and swiss homocysteine society): consensus paper on the rational clinical use of homocysteine, folic acid and B-vitamins in cardiovascular and thrombotic dis- eases: guidelines and recommendations. Clin Chem Lab Med 2003;41:1392-403
Elshorbagy, A.K., et al., Cysteine supplementation re- verses methionine restriction effects on rat adiposity: sig- nificance of stearoyl-coenzyme A desaturase. J Lipid Res 2011;52:104-12. 4. de la Calle, M., et al., Homocysteine, folic acid and B- group vitamins in obstetrics and gynaecology. Eur J Obstet Gynecol Reprod Biol 2003;107:125-34
Verhoef, P., et al., A high-protein diet increases postpran- dial but not fasting plasma total homocysteine concentra- tions: a dietary controlled, crossover trial in healthy vol- unteers. Am J Clin Nutr 2005;82:553-8
Haulrik, N., et al., Effect of protein and methionine in- takes on plasma homocysteine concentrations: a 6-mo ran- domized controlled trial in overweight subjects. Am J Clin Nutr, 2002;76:1202-6
Rees, W.D., F.A. Wilson, and C.A. Maloney, Sulfur amino acid metabolism in pregnancy: the impact of methionine in the maternal diet. J Nutr 2006;136(6 Suppl):1701S- 1705S
Yenicesu, G.I., et al., A prospective case-control study an- alyzes 12 thrombophilic gene mutations in Turkish cou- ples with recurrent pregnancy loss. Am J Reprod Immunol 2010;63:126-36
Kluijtmans, L.A., et al, Genetic and nutritional factors contributing to hyperhomocysteinemia in young adults. Blood 2003;101:2483-8
Verhoef, P., et al., Dietary serine and cystine attenuate the homocysteine-raising effect of dietary methionine: a ran- domized crossover trial in humans. Am J Clin Nutr 2004; 80:674-9
Burrin, D.G. and B. Stoll, Emerging aspects of gut sulfur amino acid metabolism. Curr Opin Clin Nutr Metab Care 2007;10:63-8
Niculescu, M.D. and S.H. Zeisel, Diet, methyl donors and DNA methylation: interactions between dietary folate, methionine and choline. J Nutr 2002;132(8 Suppl): 2333- 2335
Williams, K.T. and K.L. Schalinske, New insights into the regulation of methyl group and homocysteine metabolism. J Nutr 2007;137:311-4
Dikmen, M., Homosistein Metabolizması ve Hastalıklarla İlişkisi. J Med Sci 2004;24:645-52