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Journals / Erciyes Medical Journal / 2015 / Cilt: 37 - Sayı: 4

Possible Activation of the Immune System by Chronic Peripheral Nesfatin-1 Application at the Acute Phase of Ischemia/Reperfusion Injury

Ümran TORU
CEYLAN AYADA
Osman GENÇ
RAZİYE AKCILAR
Server ŞAHİN
Gülten ERKEN
HAYDAR ALİ ERKEN
Günfer TURGUT
Sebahat TURGUT
Pages
143–147
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

This effect of nesfatin-1 may also increase the rejection of grafts during transplantation period

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Organ transplantation is one of the clinical scenarios involving ischemia and reperfusion process.
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Key Findings & Data:Nesfatin-1 is a peptide involved in the regulation of homeostasis and has anti-inflammatory as well as anti-ischemic properties.
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Conclusion & Impact:This effect of nesfatin-1 may also increase the rejection of grafts during transplantation period
🔬Design:Modeling & Simulation
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Organ transplantation is one of the clinical scenarios involving ischemia and reperfusion process. Ischemia/reperfusion is the pivotal mechanism of organ injury during transplantation. Thus, ischemia/reperfusion (I/R) injury is a biphasic phenomenon that can damage the graft by inflammatory responses. The hypothalamic-pituitary-adrenal (HPA) axis is the main hormonal system that is activated under the influence of stress. Normal HPA axis activity leading to the release of glucocorticoids is essential for homeostasis and survival during stress. Cortisol, a key controller of stress response, is released by the HPA axis. The disrupted release of cortisol in response to inflammation has been shown in animal models. Nesfatin-1 is a peptide involved in the regulation of homeostasis and has anti-inflammatory as well as anti-ischemic properties. Therefore, we aimed to identify the effect of chronic peripheral nesfatin-1 application on the plasma level of cortisol in a rat model of intestinal I/R-based stress. Materials and Methods: Two-month-old 28 Wistar Albino male rats that weighed an average of 200-250 g were used and were randomly divided into the following four experimental groups (n=7): laparotomy, I/R, nesfatin-1+laparotomy, nesfatin-1+I/R. Blood samples were collected in tubes with EDTA. Plasma cortisol levels were analyzed by rat enzyme-linked immunosorbent assay (ELISA) kits.Results: Statistically significant decrease was found in the plasma level of cortisol in nesfatin-1+I/R group compared with I/R group (p=0.026) Conclusion: Nesfatin-1 application can inhibit anti-inflammatory responses under the early phase of intestinal I/R and support immune reactions by reducing plasma cortisol level. This effect of nesfatin-1 may also increase the rejection of grafts during transplantation period

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Cite This Article

TORU, Ü., AYADA, C., GENÇ, O., AKCILAR, R., ŞAHİN, S., ERKEN, G., ERKEN, H. A., TURGUT, G., TURGUT, S. (2015). Possible Activation of the Immune System by Chronic Peripheral Nesfatin-1 Application at the Acute Phase of Ischemia/Reperfusion Injury. Erciyes Medical Journal, Cilt: 37 - Sayı: 4, 143–147. https://ajindex.com/articles/207710

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