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Journals / International Journal of Medical Biochemistry / 2020 / Cilt: 3 - Sayı: 3

Exchange of thiol-disulfide pairs in scorpion envenomation

Merve ERGİN
Betül ÖZBEK İPTEÇ
Özlem BİNGÖL
Mustafa ÇALIŞKANTÜRK
Salim NESELİOGLU
Özcan EREL
Pages
150–154
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As thiol metabolism is a key component in inflammatory, immune and detoxification mechanisms, excessive thiols may be a response to these processes in scorpionism.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Objectives: The present study aims to analyze thiol-disulfide profile tests in scorpion envenomation.
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Key Findings & Data:Methods: This study included 35 patients with scorpion envenomation and 41 healthy individuals.
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Conclusion & Impact:As thiol metabolism is a key component in inflammatory, immune and detoxification mechanisms, excessive thiols may be a response to these processes in scorpionism.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Özet

Objectives: The present study aims to analyze thiol-disulfide profile tests in scorpion envenomation. Methods: This study included 35 patients with scorpion envenomation and 41 healthy individuals. Thiol-disulfide test panel and myeloperoxidase and catalase activities were determined in both groups. Results: Patients with scorpion envenomation group had significantly higher native thiol concentrations and significantly lower disulfide amounts than the control group (p=0.001, for both). Also, total thiol levels were higher in patients than healthy individuals (p>0.05). Significantly decreased the disulfide/native thiol ratios and significantly increased disulfide/total thiol ratios and native/total thiol ratios were obtained in patients with scorpion sting than in the healthy subjects (p<0.001, for all ratios). Both catalase and myeloperoxidase activities increased in patients with scorpionism than controls (p<0.05, for both).There were powerful relationships among enhanced myeloperoxidase activities and thiol-disulfide system tests (p<0.05, for all). Conclusion: The equilibrium between thiol-disulfide couples was disrupted in scorpion envenomation. As thiol metabolism is a key component in inflammatory, immune and detoxification mechanisms, excessive thiols may be a response to these processes in scorpionism.

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Cite This Article

ERGİN, M., İPTEÇ, B. Ö., BİNGÖL, Ö., ÇALIŞKANTÜRK, M., NESELİOGLU, S., EREL, Ö. (2020). Exchange of thiol-disulfide pairs in scorpion envenomation. International Journal of Medical Biochemistry, Cilt: 3 - Sayı: 3, 150–154. https://ajindex.com/articles/207687

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