Journals / Anestezi Dergisi / 2009 / Cilt: 17 - Sayı: 4

The effect of dexmedetomidine diluted in 5 % dextrose to prevent propofol injection pain

Propofol enjeksiyon ağrısını önlemede % 5 dekstroz ile dilüe edilen deksmedetomidinin etkisi

Pages
201–204
DOI
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Conclusion: As a result, dexmedetomidine diluted in 5 % dextrose, due to its peripheral antinociceptive effects, is found to be more effective than 5 % dextrose to prevent propofol injection pain.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Propofol is the most preferred intravenous anesthetic agent with a rapid onset and recovery but the worst disadvantage is its injection pain.
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Key Findings & Data:Materials-Method: ASA I-II, 96 patients sheduled for elective surgery were included into the study and were divided into two groups as dexmedetomidine-dextrose and dextrose.
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Conclusion & Impact:Conclusion: As a result, dexmedetomidine diluted in 5 % dextrose, due to its peripheral antinociceptive effects, is found to be more effective than 5 % dextrose to prevent propofol injection pain.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Propofol is the most preferred intravenous anesthetic agent with a rapid onset and recovery but the worst disadvantage is its injection pain. Many methods were used to prevent injection pain since it influences the patient satisfaction. In this study, it was aimed to investigate the effects of dexmedetomidine and dextrose in alleviating propofol injection pain. Materials-Method: ASA I-II, 96 patients sheduled for elective surgery were included into the study and were divided into two groups as dexmedetomidine-dextrose and dextrose. Tourniquet was left inflated for 1 min at 70 mmHg and dexmedetomidine (0.2 mg kg-1, 5 ml, diluted in 5 % dextrose) or 5 ml 5 % dextrose were injected. After the release of the tourniquet, 5 ml of total propofol dose (2.5 mg kg-1) was injected in 5 seconds. Pain assesment was performed by questioning the patient (using 4 point (0-1-2-3) scale). Two groups were compared statistically by Chi-square test, p< 0.05 was considered as statistically significant. Results: There were no injection pain in 33 patients in group dexmedetomidine-dextrose, and 23 patients in group dextrose (P=0.005). The number of patients with mild (score 1) and moderate pain (score 2) score in dextrose group was statistically higher than the dexmedetomidine-dextrose group (p< 0.05). Conclusion: As a result, dexmedetomidine diluted in 5 % dextrose, due to its peripheral antinociceptive effects, is found to be more effective than 5 % dextrose to prevent propofol injection pain.

Özet

Amaç: Propofol hızlı etki ve derlenme süresi ile anestezi indüksiyonunda sık kullanılan intravenöz anesteziktir ancak en büyük dezavantajı enjeksiyonunun ağrılı olmasıdır. Hasta memnuniyetini doğrudan etkileyen bir faktör olduğundan önlenmesi için değişik yöntemler kullanılmıştır. Bu çalışmada, dekstroz ile dilüe edilen deksmedetomidinin propofol enjeksiyon ağrısını azaltmadaki etkilerinin araştırılması amaçlanmıştır. Gereç ve Yöntem: ASA I-II, elektif genel anestezi alacak 96 hasta çalışmaya dahil edilerek Deksmedetomidin-Dekstroz Grubu ve Dekstroz Grubu olmak üzere ikiye ayrıldı. 1 dakika süreyle 70 mmHg turnike uygulanan kola, deksmedetomidin (0.2 mg kg-1, 5 mL, % 5 dekstroz ile tamamlanmış) veya 5 mL % 5 dekstroz verildi. Turnike indirildikten sonra toplam propofolün (2.5 mg kg-1) dörtte biri 5 saniyede enjekte edildi. Ağrının değerlendirilmesi 4 puanlı ağrı skoru kullanılarak yapıldı. Ki-kare testi ağrı parametresinin karşılaştırılması için kullanıldı, p< 0.05 değeri istatistiksel olarak anlamlı kabul edildi. Bulgular: Deksmedetomidin-Dekstroz Grubu’nda 33 hastada, Dekstroz Grubu’nda 23 hastada propofol ile enjeksiyon ağrısı olmamıştır (p= 0.005). Dekstroz Grubu’nda hafif (skor 1) ve orta (skor 2) derecede ağrı duyan hasta sayısı diğer gruptan istatistiksel olarak fazladır (p< 0.05). Sonuç: Propofol enjeksiyon ağrısını önlemede dekstroz ile dilüe edilen deksmedetomidinin periferik antinosiseptif etkisi nedeniyle % 5 dekstrozdan daha etkili bir yöntem olabileceğini saptadık.

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Cite This Article

UZUN, Ş., KARAGÖZ, A. H., KÖSE, E. A., CANBAY, Ö., ÖZGEN, S. (2009). The effect of dexmedetomidine diluted in 5 % dextrose to prevent propofol injection pain. Anestezi Dergisi, Cilt: 17 - Sayı: 4, 201–204. https://ajindex.com/articles/205815

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