Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2013 / Cilt: 19 - Sayı: 1

Hipertansif Gebelerde Preeklampsi Şiddeti ve Trombositopenin Prognoz Üzerine Etkileri

The Effects of Preeclampsia Severity and Thrombocytopenia on the Prognosis of Hypertensive Pregnant Women

Pages
12–18
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Furthermore, the risk for the development of complications increases with a decreased platelet count.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: The present study was aimed to determine the effects of preeclampsia severity and thrombocytopenia on maternal and fetal prognosis in hypertensive pregnant women, and to discuss the clinical and biochemical findings in light of the literature.
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Key Findings & Data:STUDY DESIGN: Three hundred and one pregnant patients, who had been admitted to the Department of Obstetrics and Gynecology of our clinic, with the diagnosis of preeclampsia between October 2006 and October 2008, were retrospectively evaluated.
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Conclusion & Impact:Furthermore, the risk for the development of complications increases with a decreased platelet count.
🔬Design:Research Article
📍Scope:2006 Verileri
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The present study was aimed to determine the effects of preeclampsia severity and thrombocytopenia on maternal and fetal prognosis in hypertensive pregnant women, and to discuss the clinical and biochemical findings in light of the literature. STUDY DESIGN: Three hundred and one pregnant patients, who had been admitted to the Department of Obstetrics and Gynecology of our clinic, with the diagnosis of preeclampsia between October 2006 and October 2008, were retrospectively evaluated. The patients were divided into two groups as patients with mild and severe preeclampsia. Additionally, the patients were analyzed in two subgroups according to their platelet counts, as the groups with low and normal platelet counts. RESULTS: When the patients with mild and severe preeclampsia were compared with regard to maternal complications, no significant difference was determined between the two groups (p > 0.05). However, a significant difference was noted between the groups with respect to the development of eclampsia and HELLP syndrome (p < 0.05). Eclampsia (n=17; 12%) and HELLP syndrome (n=30; 21.1%) were more common in the patients with severe preeclampsia. On the other hand, no significant difference was noted between the two groups in terms of fetal outcomes (p > 0.05). When the patients with low and the normal platelet counts were compared with respect to maternal complications, it was noted that HELLP syndrome (n=39; 51%) and eclampsia (n=11; 14.5%) were more common in patients with low platelet counts, when compared to the patients with normal platelet counts, and difference between the two groups was significant (p < 0.05). Birth weight was significantly lower in patients with low platelet counts (p < 0.05). CONCLUSIONS: There is a significant relationship between the severity of preeclampsia and potential complications. The risk for the development of HELLP syndrome and eclampsia increases in patients with severe preeclampsia. Furthermore, the risk for the development of complications increases with a decreased platelet count.

Özet

AMAÇ: Hipertansif gebelerde preeklampsi şiddeti ve trombositopeni varlığının maternal ve fetal prognoz üzerine olan etkilerinin değerlendirilmesi, klinik ve biyokimyasal sonuçların incelenerek literatür eşliğinde tartışılması amaçlandı. GEREÇ VE YÖNTEM: Ekim 2006 - Ekim 2008 tarihleri arasında Ondokuz Mayıs Üniversitesi Tıp Fakültesi Kadın Hastalıkları ve Doğum Kliniği'ne preeklampsi tanısıyla başvuran 301 olgu retrospektif olarak incelendi. Hastalar hafif ve ağır preeklamptik olgular olmak üzere iki gruba; trombosit sayılarına göre de, düşük ve normal trombosit grupları olmak üzere iki alt gruba ayrıldı. BULGULAR: Hafif ve ağır preeklamptik hastalar maternal komplikasyonlar açısından karşılaştırıldığında; gruplar arasında istatistiksel olarak anlamlı fark saptanmadı (p > 0,05). Eklampsi ve HELLP sendromu gelişimi açısından ise anlamlı fark saptandı (p 0,05). Trombosit sayılarına göre ayrılan gruplar, maternal komplikasyonlar açısından karşılaştırıldığında; düşük trombosit grubunda HELLP sendromu 39 (%51), eklampsi 11 (%14,5), normal trombosit grubundan daha sık izlendi ve gruplar arası fark istatistiksel olarak anlamlı tespit edildi (p < 0.05). Bebek doğum ağırlığı, düşük trombosit grubunda istatiksel anlamlı olarak daha düşük izlendi (p < 0,05). SONUÇ: Preeklampsinin şiddeti ile gelişebilecek komplikasyonlar arasında anlamlı ilişki bulunmaktadır. Ağır preeklamptik grupta HELLP sendromu ve eklampsi gelişme olasılığı artmaktadır. Yine trombosit sayısı düştükçe, komplikasyon gelişme olasılığı artmaktadır.

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Cite This Article

BEŞE, E., BILDIRCIN, F. D., MALATYALIOĞLU, E. (2013). Hipertansif Gebelerde Preeklampsi Şiddeti ve Trombositopenin Prognoz Üzerine Etkileri. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 19 - Sayı: 1, 12–18. https://ajindex.com/articles/204969

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