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Journals / Genel Tıp Dergisi / 2013 / Cilt: 23 - Sayı: 4

The mechanism of oxidative stress in patients with adenomatous colon polyps, evaluation of the arylesterase and paraoxonas

Adenomatöz kolon polipli hastalarda oksidatif stres mekanizmasının paraoksonaz ve arilesteraz üzerinden değerlendirilmesi

Murat AYDIN
Feti TULUBAŞ
İLHAN BALİ
Rafet METE
Mustafa ORAN
OĞUZHAN YILDIRIM
Filiz TURAN
Ahmet GÜREL
Pages
120–123
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: A significant decrease in serum paraoxonase and stimulated paraoxonase activity lead to an increase in oxidative stress may play a role in the pathophysiology of adenomatous colon polyps

📌 3 Key Takeaways

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Objective & Hypothesis:Objectives: Adenomatous polyps is characterized by the development of adenomas into the lumen in the rectum and colon.
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Key Findings & Data:Increased oxidative stress plays a role in many degenerative diseases and tumor pathogenesis.
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Conclusion & Impact:Conclusion: A significant decrease in serum paraoxonase and stimulated paraoxonase activity lead to an increase in oxidative stress may play a role in the pathophysiology of adenomatous colon polyps
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objectives: Adenomatous polyps is characterized by the development of adenomas into the lumen in the rectum and colon. Increased oxidative stress plays a role in many degenerative diseases and tumor pathogenesis. The aim of this study in patients with adenoma- tous colon polyps paraoxonase, stimulated paraoxonase and arylesterase detection and reveal the relationship between oxidative stress and pathophysiology of the disease. Materials and methods: Patients admitted to Namik Kemal University Research and Training Hospital Gastroenterology Clinic with adenomatous polypossis and healty controls were studied. Paraoxonase, stimulated paraoxonase and arylesterase measurements were performed spectrophotometrically with manual methods. Results: The levels of pa- raoxonase and stimulated paraoxonase activity in patients with adenomatous polyps were found to be significantly lower than healthy controls, arylesterase activity were significantly higher than in healthy controls, but the difference was not statistically significant. Conclusion: A significant decrease in serum paraoxonase and stimulated paraoxonase activity lead to an increase in oxidative stress may play a role in the pathophysiology of adenomatous colon polyps

Özet

Amaç: Adenomatöz polip, rektum ve kolonda adenomların lümene doğru gelişimi ile karakterize klinik bir durumdur. Birçok dejeneratif ve tümöral hastalığın patogenezinde artmış oksidatif stres rol oynamaktadır. Bu çalışma adenomatöz kolon polipli hastalarda paraoksonaz, indüklenebilir paraoksonaz ve arilesteraz enzim aktivitelerinin tespiti ve oksidatif stres ile hastalığın patofizyolojisi arasındaki ilişkiyi ortaya koymak amacı ile planlanmıştır. Gereç ve yöntem: Namık Kemal Üniversitesi Araştırma ve Uygulama Hastanesi Gastroenteroloji Polikliniği'ne başvuran hastalardan kolon polipi saptananlar ve sağlıklı gönüllüler çalışmaya alındı. Paraoksonaz, indüklenebilir paraoksonaz ve arilesteraz düzeylerinin ölçümleri spektrofotometrik olarak yapıldı. Bulgular: Kolon polipli hastalar ile sağlıklı kontroller karşılaştırıldığında, kolon polipli hastalarda, paraoksonaz, indüklenebilir paraoksonaz aktiviteleri istatistiksel olarak anlamlı oranda düşük bulunurken, arilesteraz aktivitesinde istatistiksel olarak anlamlı fark bulunmadı. Sonuç: Kolon polipli hastalarda paraoksonaz ve indüklenebilir paraoksonaz aktivitesinin sağlıklı polülasyondan düşük bulunması, oksidan-antioksidan dengenin oksidan yönünde bozulmasının polipli hastalarda polip gelişimi ile yakın ilişki içinde olduğunu düşündürmektedir

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Cite This Article

AYDIN, M., TULUBAŞ, F., BALİ, İ., METE, R., ORAN, M., YILDIRIM, O., TURAN, F., GÜREL, A. (2013). The mechanism of oxidative stress in patients with adenomatous colon polyps, evaluation of the arylesterase and paraoxonas. Genel Tıp Dergisi, Cilt: 23 - Sayı: 4, 120–123. https://ajindex.com/articles/204314

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