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Journals / ANKEM Dergisi / 2006 / Cilt: 20 - Sayı: 3

Extended-spectrum beta-lactamases in gram-negative bacilli isolated from nosocomial infections

Hastane kökenli gram negatif bakterilerde genişlemiş spektrumlu beta-laktamazlar

Mustafa Kemal ÇELEN
Celal AYAZ
Mehmet Faruk GEYİK
Salih HOŞOĞLU
Mehmet ULUĞ
Pages
148–151
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

As a result it is very important that each hospital should create their rational antibiotic management strategies.

📌 3 Key Takeaways

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Objective & Hypothesis:Hundred and eighty-two Gram negative bacterial strains isolated in Dicle University Hospital, Infectious Diseases Laboratory and Central Laboratory in two-years period (2003-2004) and assessed as the etiological agents in nosocomial infections according to the Centers for Disease Control criteria were investigated for extended-spectrum beta-lactamase production (ESBL).
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Key Findings & Data:ESBL production was detected in 24 of 51 (47 %) Klebsiella spp., in 14 of 42 (33 %) Escherichia coli, in 13 of 39 (33 %) Pseudomonas spp., in 4 of 17 Acinetobacter spp., in 4 of 15 Enterobacter clocae, in 2 of 11 Proteus spp., in 1 of 3 Serratia marcescens and in none of 4 Citrobacter freundii strains.
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Conclusion & Impact:As a result it is very important that each hospital should create their rational antibiotic management strategies.
🔬Design:Research Article
📍Scope:2003-2004 Verileri
⚙️Variables:Anti-bakteriyel ajanlar · beta-Laktamazlar · Hastalık kontrol ve koruma merkezleri (A.B.D.)

Abstract

Hundred and eighty-two Gram negative bacterial strains isolated in Dicle University Hospital, Infectious Diseases Laboratory and Central Laboratory in two-years period (2003-2004) and assessed as the etiological agents in nosocomial infections according to the Centers for Disease Control criteria were investigated for extended-spectrum beta-lactamase production (ESBL). ESBL production was detected in 24 of 51 (47 %) Klebsiella spp., in 14 of 42 (33 %) Escherichia coli, in 13 of 39 (33 %) Pseudomonas spp., in 4 of 17 Acinetobacter spp., in 4 of 15 Enterobacter clocae, in 2 of 11 Proteus spp., in 1 of 3 Serratia marcescens and in none of 4 Citrobacter freundii strains. The total number of ESBL producing strains was 62 in 182 (34 %). This ratio was 31 % in the year 2001 (p>0.05). Infections with ESBL producing organisms can pose a therapeutic challenge; leading to treatment failure when wrong class of antibiotics are used. As a result it is very important that each hospital should create their rational antibiotic management strategies.

Özet

Dicle Üniversitesi Hastanesi, Enfeksiyon Hastalıkları ve Klinik Mikrobiyoloji Laboratuvarı ve Merkez laboratuvarında iki yıllık sürede (2003-2004) değişik klinik örneklerden soyutlanan ve Centers for Disease Control kriterlerine göre hastane infeksiyonu etkeni olarak kabul edilen 182 Gram negatif bakteride genişlemiş spektrumlu beta-laktamaz (GSBL) oluşturma E-test yöntemi ile araştırılmıştır. Klebsiella spp.’de 24/51 (% 47), Escherichia coli’de 14/42 (% 33), Pseudomonas spp.’de 13/39 (% 33), Acinetobacter spp.’de 4/17, Enterobacter cloacae’de 4/15, Proteus spp.’de 2/11, Serratia marcescens’de 1/3 oranında GSBL saptanmış, 4 Citrobacter freundii’de GSBL saptanmamıştır. 2001 yılında hastanemizde Gram negatif çomaklarda % 31 olan GSBL oluşturma bu çalışmada da % 34 (62/182) olarak belirlenmiş olmasına karşın istatistiksel olarak anlamlı bir fark saptanmamıştır (p>0.05). Özellikle rasyonel olmayan antibiyotik kullanımı ciddi hastane infeksiyonlarına yol açacak dirençli bakterileri öne çıkarmaktadır. Bu önemli sorun, kontrollü antibiyotik kullanımını sağlayacak stratejilere gereksinim olduğunu göstermektedir.

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Cite This Article

ÇELEN, M. K., AYAZ, C., GEYİK, M. F., HOŞOĞLU, S., ULUĞ, M. (2006). Extended-spectrum beta-lactamases in gram-negative bacilli isolated from nosocomial infections. ANKEM Dergisi, Cilt: 20 - Sayı: 3, 148–151. https://ajindex.com/articles/204046

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