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Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2013 / Cilt: 19 - Sayı: 3

Normoresponder hastalarda bazal testosteron ve dehidroepiandrosteron sülfat düzeylerinin in vitro fertilizasyon sonuçlarına etkisi

Effect of basal testosterone and dehydroepiandrosterone sulphate levels on in vitro fertilization outcome in normoresponders

İNCİ KAHYAOĞLU
NAFİYE YILMAZ
SERKAN KAHYAOĞLU
AYTEN TÜRKKANI
Mahmut Nedim ÇİÇEK
Leyla MOLLAMAHMUTOĞLU
Pages
171–175
DOI
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AI Summary & Key Takeaways

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CONCLUSION: There is no correlation between testosterone and DHEAS levels and COH parameters in normoresponder IVF patients.

📌 3 Key Takeaways

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Objective & Hypothesis:OBJECTIVE: The purpose of the present study is to evaluate the predictive value of basal total testos- terone (total-T) and dehydroepiandrosterone sulphate (DHEAS) levels in normoresponder patients un- dergoing IVF-ET.
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Key Findings & Data:STUDY DESIGN: A total of 60 normoresponder infertile women, scheduled to undergo their first IVF/ET cycle were enrolled in this study.
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Conclusion & Impact:CONCLUSION: There is no correlation between testosterone and DHEAS levels and COH parameters in normoresponder IVF patients.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

OBJECTIVE: The purpose of the present study is to evaluate the predictive value of basal total testos- terone (total-T) and dehydroepiandrosterone sulphate (DHEAS) levels in normoresponder patients un- dergoing IVF-ET. STUDY DESIGN: A total of 60 normoresponder infertile women, scheduled to undergo their first IVF/ET cycle were enrolled in this study. Day 2-4 basal concentrations of FSH, LH, E2, total testosterone, DHEAS and antral follicle count (AFC) were determined in preceding cycle. RESULTS: No significant difference was found between pregnant and non-pregnant groups regarding the AFC, hormone and controlled ovarian hyperstimulation (COH) parameters (total dose of go- nadotrophins (1995.7±851.1 vs 2296.4±845.3 IU), >14 mm follicles (9.3±3.1 vs 7.3±3.9), retrieved oocytes (12.4±5.1 vs 8.7±6.1) or number of good quality embryos (7.4±3.7 vs 4,4±3.6) (p>0.05). Testosterone and DHEAS was not correlated with COH parameters (p>0.05). CONCLUSION: There is no correlation between testosterone and DHEAS levels and COH parameters in normoresponder IVF patients.

Özet

AMAÇ: Bu çalışmanın amacı normoresponder hastalarda ba- zal androjen düzeylerinin IVF sonuçlarına etkisini değerlendir- mektir. GEREÇ VE YÖNTEM: İlk IVF/ET denemesi için kabul edilen 60 normoresponder hastanın siklusun 2-4. günlerinde bazal serum FSH, LH, E2, Total-Testosteron (total-T), Dehidroepi- androsteron sülfat (DHEAS) düzeyleri ve antral follikül sayıları (AFS) değerlendirildi. BULGULAR: Gebe kalan ve kalamayan hastalar karşılaştırıldı- ğında AFS, hormon ve kontrollü ovaryan hiperstimülasyon (KOH) parametreleri (kullanılan total gonadotropin miktarı (1995,7±851,1 vs 2296,4±845,3 IU), 14 mm üzerinde folikül sa- yısı (9,3±3,1 vs 7,3±3,9), elde edilen oosit sayısı (12,4±5,1 vs 8,7±6,1) ve iyi kalitede embriyo sayıları (7,4±3,7 vs 4,4±3,6) arasında istatistiksel olarak anlamlı fark saptanmadı (p>0,005). Testosteronun ve DHEAS ile KOH parametreleri arasında ista- tistiksel olarak anlamlı korelasyon saptanmadı (p>0,05). SONUÇ: Normoresponder hasta grubunda bazal testosteron ve DHEAS düzeyleri ile İVF stimülasyon parametreleri arasın- da korelasyon yoktur.

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Cite This Article

KAHYAOĞLU, İ., YILMAZ, N., KAHYAOĞLU, S., TÜRKKANI, A., ÇİÇEK, M. N., MOLLAMAHMUTOĞLU, L. (2013). Normoresponder hastalarda bazal testosteron ve dehidroepiandrosteron sülfat düzeylerinin in vitro fertilizasyon sonuçlarına etkisi. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 19 - Sayı: 3, 171–175. https://ajindex.com/articles/203641

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