Journals / Bezmiâlem Science / 2018 / Cilt: 6 - Sayı: 3

Asymptomatic Bacteriuria in Pregnancy: Prevalence, Antibiotic Susceptibility, and Related Demographic Factors

Gebelik Dönemindeki Asemptomatik Bakteriüri: Prevalansı, Antibyotik Duyarlılığı ve Demografik Faktörlerle İlişkisi

Pages
163–167
DOI
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Fosfomycin is the preferred treatment because it has high sensitivity rate and is safe and easy- to-use.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to establish the prevalence of asymptomatic bacteriuria (ABU) in pregnancy.
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Key Findings & Data:Methods: Our study was conducted in 980 pregnant women.
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Conclusion & Impact:Fosfomycin is the preferred treatment because it has high sensitivity rate and is safe and easy- to-use.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: The aim of this study was to establish the prevalence of asymptomatic bacteriuria (ABU) in pregnancy. It is the most common urinary infection among pregnant women in our area. Methods: Our study was conducted in 980 pregnant women. Gestational age of each woman was less than 20 weeks. Patients with any urinary tract infection symptoms, suprapubic pain, painful and frequent urination, urinary incontinence, smelly vaginal discharge indicating prolonged or recent antibiotic use, history of kidney disease or kidney stones, or gestational diabetes were excluded from this study. Urine culture and antibiogram of mid-stream urine were performed. The pregnant women di- agnosed as having bacteriuria were treated with antibiotics for 7 days. Results: There was no statistical significant association among age, gravida, parity, and sex activity in 749 pregnant women screened for ABU. Among 749, 53 pregnant women presented with ABU (7.1%). Among these 53 patients, Escherichia coli was the most frequently isolated microorganism that was detect- ed in 36 women (69%). E. coli is sensitive to 99.3% fosfomycin and 85% cefuroxime. Klebsiella pneumoniae, the second most common microorganism, is sensitive to 86% fosfomycin and 100% cefepime and ceftriaxone. Enterococcus species, the third most common microorganism, is sensitive to 100% ampicillin and fosfomycin. Conclusion: Pregnant women should be screened for ABU. The most appropriate period for screening is between 9 and 17 weeks of pregnancy, preferably 16. Gestational age should be measured using mid-stream urine culture. Fosfomycin is the preferred treatment because it has high sensitivity rate and is safe and easy- to-use.

Özet

Amaç: Amacımız bölgemizde doğum kliniğine gelen gebelerde- ki asemptomatik bakteriüri (ABÜ) prevelansını, en sık görülen mikroorganizmayı ve antibiyotik duyarlılıklarını belirlemektir. Yöntemler: Çalışmamız 20. gebelik haftasından önce antenatal vizite gelen 980 gebe ile yapıldı. İdrar yolları enfeksiyonu bulgu- ları, suprapubik ağrı şikayeti, ağrılı idrar yapma, sık idrara çıkma, idrar kaçırma ve vajinal akıntı ile kötü koku semptomları olan hastalar, aktif antibiyotik kullanan veya son bir ay içerisinde kul- lanmış olan hastalar, medikal öyküsünde böbrek hastalığı, böb- rek taşı öyküsü olan hastalar ile gestasyonel diyabet tanılı gebeler çalışma dışı bırakıldı. Orta idrardan kültür alınıp antibiyogram yapıldı. Bakteriüri tespit edilen gebeler antibiyogram sonucuna göre etkenin duyarlı olduğu bir antibyotikle 7 gün tedavi edildi. Bulgular: ABÜ için taranan 749 gebenin yaş, gravide, parite ve seks aktivitesi açısından fark olmadığı izlendi. Çalışmaya alınan 749 gebenin 53’ünde (%7,1) ABÜ tespit edildi. ABÜ tespit edilen 53 gebenin ise 36’sında (%69) E. coli en sık izole edilen mikroorganizma oldu. E. coli fosfomisine %99,3 oranında, sefu- roksime ise %85 oranında duyarlı bulundu. İkinci sıklıkta izole edilen mikroorganizma Klebsiella pneumoniae ise fosfomisine %86 oranında, sefepime ve seftriaksona ise %100 duyarlı bulun- du. Üçüncü sıklıkta izole edilen Enterococcus spp. ise ampisiline ve fosfomisine %100 oranında duyarlı bulundu. Sonuç: ABÜ prevalansı gebelikte önemli olarak yüksektir. Dü- şük ve erken doğum açısından risk oluşturan bir klinik tablo olduğu için taranması önerilmektedir. En uygun tarama hafta- ları ikinci trimester başlarında orta akım idrar kültürüyle yapılır. Tedavide etken mikroorganizmalara karşı duyarlılığının yüksek olması, kolay kullanımı ve güvenli olması sebebiyle fosfomisin tercih edilebilir.

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Cite This Article

TAMER, L. H. A., KARACA, N., AKPAK, Y. K. (2018). Asymptomatic Bacteriuria in Pregnancy: Prevalence, Antibiotic Susceptibility, and Related Demographic Factors. Bezmiâlem Science, Cilt: 6 - Sayı: 3, 163–167. https://ajindex.com/articles/202259

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