Cytogenetic Features of Elderly Turkish Myelodysplastic Syndrome Patients

Although the pathogenesis of MDS is still poorly understood, environmental and biological factors could induce mechanisms that are associated with diverse karyotypes and variable frequencies of chromosomal abnormalities.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Myelodysplastic syndrome (MDS) represents one of the most frequent and serious hematologic diseases among the elderly.

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Key Findings & Data:Chromosomal abnormalities have been detected in 23%-78% patients with MDS.

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Conclusion & Impact:Although the pathogenesis of MDS is still poorly understood, environmental and biological factors could induce mechanisms that are associated with diverse karyotypes and variable frequencies of chromosomal abnormalities.

🔬Design:Research Article

📍Scope:2011 Verileri

⚙️Variables:Domain Parameters

Abstract

Objective: Myelodysplastic syndrome (MDS) represents one of the most frequent and serious hematologic diseases among the elderly. Chromosomal abnormalities have been detected in 23%-78% patients with MDS. We analyzed the cytogenetics of elderly MDS patients in Turkey. Materials and Methods: Data on patients (>65 years old) diagnosed with primary MDS from 2011 to 2013 were retrospectively collected from Erciyes University. Chromosome analysis was performed in 54 patients using conventional karyotyping and fluorescence in situ hybridization (FISH). Results: Of the 54 patients recruited, karyotype abnormalities were found in 8 (15%) of 54 cases, among which, 5 (9%) were Trisomy 8 and 3 (6%) were del 5q. Conclusion: The incidence of chromosomal abnormalities in elderly Turkish MDS patients was lower than that reported in the literature. Although the pathogenesis of MDS is still poorly understood, environmental and biological factors could induce mechanisms that are associated with diverse karyotypes and variable frequencies of chromosomal abnormalities.

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Cite This Article

KEKLİK, M., BÜYÜKOĞLAN, R., ŞIVGIN, S., ESER, B., KAYNAR, L., ÇETİN, M., ÜNAL, A., KEKLİK, E., ÖZKUL, Y. (2016). Cytogenetic Features of Elderly Turkish Myelodysplastic Syndrome Patients. Erciyes Medical Journal, Cilt: 38 - Sayı: 3, 95–98. https://ajindex.com/articles/201518

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