The Value of Fibrosis Index in Discrimination of Chronic Hepatitis and Cirrhosis

Conclusion: Fibrosis index may be valuable in monitoring of patients with chronic hepatitis and may be helpful in selecting patients who require biopsy.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: To evaluate the value of Doppler ultrasonography (US) and fibrosis index in differentiating between chronic hepatitis and cirrhosis.

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Key Findings & Data:Methods: Sixty-seven non-cirrhotic viral hepatitis B and C patients and 28 cirrhotic patients were included in this study.

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Conclusion & Impact:Conclusion: Fibrosis index may be valuable in monitoring of patients with chronic hepatitis and may be helpful in selecting patients who require biopsy.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Abstract

Aim: To evaluate the value of Doppler ultrasonography (US) and fibrosis index in differentiating between chronic hepatitis and cirrhosis. Methods: Sixty-seven non-cirrhotic viral hepatitis B and C patients and 28 cirrhotic patients were included in this study. All patients were examined by liver Doppler US. Quantitative Doppler parameters were obtained and fibrosis index was calculated. The results were evaluated statistically and a cut-off value for fibrosis index was obtained to differentiate between chronic hepatitis and cirrhosis groups. Results: The mean fibrosis index value in chronic hepatitis group and cirrhotic patients was 3.23±0.85 and 5.40±1.8, respectively. The difference between the two groups was statistically significant (p<0.05). Taking a cut-off value of 4.57 for fibrosis index, a sensitivity of 97% and a specificity of 71% were obtained. Conclusion: Fibrosis index may be valuable in monitoring of patients with chronic hepatitis and may be helpful in selecting patients who require biopsy.

Özet

Amaç: Kronik hepatit ve siroz ayrımında Doppler ultrasonografi (US) ve fibrozis indeksinin değerini araştırmaktır.Yöntemler: Bu çalışmaya 67 hepatit B ve C'si olan ancak siroz gelişmeyen hasta ve 28 siroz hastası katıldı. Tüm hastalara karaciğere yönelik Doppler US yapıldı. Kantitatif Doppler parametreleri elde edildi ve fibrozis indeksi hesaplandı. Sonuçlar istatistiksel olarak karşılaştırıldı ve kronik hepatit ve siroz gruplarını ayırmak için fibrozis indeks eşik değeri elde edildi.Bulgular: Kronik hepatit hasta grubunda fibrozis indeks değeri ortalama 3,23±0,85 bulundu. Siroz hasta grubunda ise fibrozis indeks değeri ortalama 5,40±1,8 bulundu. Her iki grup arasında fibrozis indeksleri açısından anlamlı farklılık mevcuttu (p<0,05). Fibrozis indeks eşik değeri 4,57 seçildiğinde duyarlılık %97, özgüllük ise %71 bulundu. Sonuç: Fibrozis indeksi kronik hepatit hastalarının takibinde ve biyopsi yapılacak hastaların seçiminde faydalı olabilir.

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Cite This Article

SÖKER, G., GÜLEK, B., ÖZTÜRK, A. B., YILMAZ, C., KARABIYIK, Ö., AKIN, M. A., KAYA, Ö., DİLEK, O. (2017). The Value of Fibrosis Index in Discrimination of Chronic Hepatitis and Cirrhosis. Haseki Tıp Bülteni, Cilt: 55 - Sayı: 3, 212–215. https://ajindex.com/articles/201439

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