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Journals / ANKEM Dergisi / 2006 / Cilt: 20 - Sayı: 1

The growth rates, isolated agents and their antibiotic resistance in febrile neutropenic attacks between 2000-2004 years

2000-2004 yılları arasında takip edilen febril nötropeni ataklarındaki kültürlerde üreme oranları, üreyen etkenler ve antibiyotik dirençleri

Tiraje CELKAN
Şuküfe DİREN
İsa ÖZYILMAZ
Serap KARAMAN
AYLİN CANBOLAT AYHAN
Alp ÖZKAN
Hilmi APAK
İnci YILDIZ
Pages
4–9
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

For the time being the antibiotic resistance does not look as a serious problem in our center.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Infections are the most important complication of patients receiving chemotherapy for neoplastic diseases.
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Key Findings & Data:With the aim of performing an evaluation of microbiological information including the number of taken cultures, the positivity ratio, type of isolated pathogens and its antibiotic susceptibility pattern, we conducted a 4 year retrospective documentation in Pediatric Hematology-Oncology Department of Cerrahpaşa Faculty of Medicine.
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Conclusion & Impact:For the time being the antibiotic resistance does not look as a serious problem in our center.
🔬Design:Research Article
📍Scope:1914 specimens
⚙️Variables:Penisilin direnci · Çocuk · İlaç direnci

Abstract

Infections are the most important complication of patients receiving chemotherapy for neoplastic diseases. Morbidity and mortality remain high, as well as the potential impact of these complications on the projected dose-intensity of chemotherapy. With the aim of performing an evaluation of microbiological information including the number of taken cultures, the positivity ratio, type of isolated pathogens and its antibiotic susceptibility pattern, we conducted a 4 year retrospective documentation in Pediatric Hematology-Oncology Department of Cerrahpaşa Faculty of Medicine. A total of 743 blood cultures were taken and in 119 (16 % of them) a pathogen was isolated. The microorganisms isolated were Gram positive cocci in 62 %, Gram negative rods in 34 % and fungi in 4 % of positive cultures. In cultures of 1914 specimens other than blood, aetiologic pathogens were Gram positive cocci (31 %), Gram negative rods (48 %) and fungi (21 %). The antibiotic resistance of some pathogens, e.g. methicillin resistance in S.aureus, penicillin resistance in alpha-hemolytic streptococcus and S.pneumoniae and third-generation cephalosporin resistance in Klebsiella are found higher than expected but the number of isolates are not enough to reach a reliable conclusion. For the time being the antibiotic resistance does not look as a serious problem in our center.

Özet

Malign hastalıkları nedeni ile kemoterapi alan hastalardaki en önemli tedavi komplikasyonu infeksiyonlardır. İnfeksiyonlar, kemoterapi doz yoğunluğunun ve bütünlüğünün bozulmasının yanında, mortalite ve morbiditeye de neden olur. Bu çalışmada Pediatrik Hematoloji-Onkoloji servisinde febril nötropeni nedeni ile takip edilen hastalardan son 4 yılda alınan kültürler incelenerek üreme oranlarının, üreyen etkenlerin identifikasyonunun ve antibiyotik duyarlılıklarının belirlenmesi amaçlanmıştır. Alınan 743 kan kültüründen 119'unda (% 16) üreme saptanmıştır (% 62 Gram pozitif bakteri, % 34 Gram negatif bakteri ve % 4 mantar). Kan kültürü dışında alınan 1914 örneğin kültürlerinde ise % 31 'inde Gram pozitif bakteri, % 48'inde Gram negatif bakteri ve % 21 'inde mantar üremiştir. İzole edilen bakterilerin antibiyotik duyarlılıkları incelendiğinde, S.aureus suşlarında metisilin direncinde, alfa-hemolitik streptokok ve pnömokok suşlarında penisilin direncinde, Klebsiella suşlarında 3.kuşak sefalosporin direncinde biraz yüksek oranlar bulunsa da suş sayıları anlamlı bir direnç yüksekliğine hükmetmek için yeterli değildir. Bu durumda merkezimizde antibiyotik direnci halen çok önemli bir sorun olarak görülmemektedir.

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Cite This Article

CELKAN, T., DİREN, Ş., ÖZYILMAZ, İ., KARAMAN, S., AYHAN, A. C., ÖZKAN, A., APAK, H., YILDIZ, İ. (2006). The growth rates, isolated agents and their antibiotic resistance in febrile neutropenic attacks between 2000-2004 years. ANKEM Dergisi, Cilt: 20 - Sayı: 1, 4–9. https://ajindex.com/articles/201371

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