Journals / Haseki Tıp Bülteni / 2018 / Cilt: 56 - Sayı: 4

Metastatic Neck Disease in Multifocal Thyroid Papillary Cancer

Multifokal Tiroid Papiller Kanserlerinde Boyun Metastatik Hastalığı

Pages
313–317
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Conclusion: We recommend bilateral total thyroidectomy and bilateral central neck dissection as primary surgical treatment in multifocal thyroid cancer patients.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Multifocal papillary thyroid cancer (MPTC) has aggressive and poor prognosis.
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Key Findings & Data:Methods: We retrospectively investigated the records of 2530 patients who underwent thyroidectomy for papillary thyroid cancer between January 2010 and December 2017.
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Conclusion & Impact:Conclusion: We recommend bilateral total thyroidectomy and bilateral central neck dissection as primary surgical treatment in multifocal thyroid cancer patients.
🔬Design:Research Article
📍Scope:2010 Verileri
⚙️Variables:Domain Parameters

Abstract

Aim: Multifocal papillary thyroid cancer (MPTC) has aggressive and poor prognosis. The main aim of this study was to evaluate the lymph node metastasis pattern in MPTC patients. Methods: We retrospectively investigated the records of 2530 patients who underwent thyroidectomy for papillary thyroid cancer between January 2010 and December 2017. The age, gender, tumor size, thyroid capsule invasion and neck metastatic disease were evaluated in 515 of these patients having MPTC. Results: We compared multifocal and unifocal papillary thyroid cancer patients considering papillary thyroid capsule invasion (29.9%/10.86%), mean tumor diameter (15.9 mm/16.1 mm), central lymph node metastasis (56.5%/18.3%) and lateral neck lymph node metastasis (23.1%/6.3%). Capsule invasion was associated with an increased risk of multifocal disease. The incidence of capsular invasion and central and lateral neck metastases in MPTC patients was statistically significantly higher than in patients with unifocal thyroid papillary cancer (p<0.001). Conclusion: We recommend bilateral total thyroidectomy and bilateral central neck dissection as primary surgical treatment in multifocal thyroid cancer patients.

Özet

Amaç: Multifokal papiller tiroid kanseri (MPTK) agresif ve kötü prognoza sahiptir, bu çalışmada MPTK‘li hastalarda boyun lenf nodu metastaz özellikleri değerlendirilmesi amaçlanmıştır. Yöntemler: Ocak 2010 - Aralık 2017 tarihleri arasında papiller tiroid kanseri tanısı ile total tiroidektomi yapılmış 2530 hastanın dosyası retrospektif olarak incelendi ve multifokal tiroid papiller kanseri saptanan 515 olgunun yaş, cinsiyet, tümör boyutu, tiroid kapsül invazyonu, boyun metastatik hastalığı değerlendirildi. Bulgular: Olgular multifokal/unifokal olarak iki gruba ayrıldı ve iki grup tiroid kapsül invazyonu (%29,9/%10,86), tümör ortalama çapı (15,9 mm/16,1 mm), santral lenf nod metastazı (%56,5/%18,3), lateral boyun lenf metastazı (%23,1/%6,3) bakımından karşılaştırıldı. Kapsül invazyonunun, multifokalite riskinde artış ile bağlantısı olduğu görüldü. Multifokal hastalarda kapsül invazyonu, santral ve lateral boyun metastazları unifokal hastalarla karşılaştırıldığında istatistiksel olarak anlamlı fark saptandı (p<0,001). Sonuç: Multifokal tiroid kanseri hastalarında primer cerrahi tedavisi olarak bilateral total tiroidektomi ile beraber bilateral santral boyun diseksiyonu yapılması tavsiye etmekteyiz.

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Cite This Article

ERTAŞ, B., KAYA, H., ÖZDİLEK, A., GİRAY, S., TOKAT, F., DÜREN, M. (2018). Metastatic Neck Disease in Multifocal Thyroid Papillary Cancer. Haseki Tıp Bülteni, Cilt: 56 - Sayı: 4, 313–317. https://ajindex.com/articles/200254

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