Ischemia-Modified Albumin Levels in Patients With Essential Thrombocytosis

The difference of metabolic parameters between the ET patient group and C group can be explained by insulin resistance and atherosclerosis background caused by chronic inflammation.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of this study was to investigate the levels of ischemia-modified albumin (IMA) in people with essential thrombocytosis (ET).Methods: A total of 30 patients with ET patient group and 30 volunteers with no known disease control group (C group) were included in this study after the approval of ethics committee and written informed consent was obtained.

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Key Findings & Data:In addition to that; comorbid disease state, drug use and used drugs group were questioned in patient group and effects of them on IMA levels were studied.Results: In our study, when ET patient group and C group were compared, the mean serum IMA levels in ET patient group and C group was detected as 0,6726 (0,527-0,776) Absorbans Unite (ABSU) and 0,4342 (0,346-0,612) ABSU respectively and in ET patient group was significantly higher than C group (p<0,001).

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Conclusion & Impact:The difference of metabolic parameters between the ET patient group and C group can be explained by insulin resistance and atherosclerosis background caused by chronic inflammation.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:İskemi Modifiye Albumin · Tromboz · Esansiyel Trombositoz

Abstract

Objective: The aim of this study was to investigate the levels of ischemia-modified albumin (IMA) in people with essential thrombocytosis (ET).Methods: A total of 30 patients with ET patient group and 30 volunteers with no known disease control group (C group) were included in this study after the approval of ethics committee and written informed consent was obtained. Patients with a history of major thrombosis were excluded. IMA levels and independent variables were investigated and effects on thrombosis susceptibility were also studied. In addition to that; comorbid disease state, drug use and used drugs group were questioned in patient group and effects of them on IMA levels were studied.Results: In our study, when ET patient group and C group were compared, the mean serum IMA levels in ET patient group and C group was detected as 0,6726 (0,527-0,776) Absorbans Unite (ABSU) and 0,4342 (0,346-0,612) ABSU respectively and in ET patient group was significantly higher than C group (p<0,001). The glucose, total cholesterol and triglyceride values were significantly higher in ET patient group (p= 0,026, p= 0,058, p= 0,004, respectively). There is a correlation between IMA concentration and age (p= 0,042).Conclusions: In our study IMA levels were found significantly high in ET patient group, this supports increased risk of thrombosis in ET. The difference of metabolic parameters between the ET patient group and C group can be explained by insulin resistance and atherosclerosis background caused by chronic inflammation.

Keywords

İskemi Modifiye Albumin Tromboz Esansiyel Trombositoz Ischemia Modified Albumin Essential Thrombocytosis Thrombosis

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Cite This Article

ERSOY, E., SOYALTIN, U. E., PEKER, A., ÇOLAK, A., CEYLAN, C., AKAR, H. (2018). Ischemia-Modified Albumin Levels in Patients With Essential Thrombocytosis. KONURALP TIP DERGİSİ, Cilt: 10 - Sayı: 3, 341–346. https://ajindex.com/articles/200058

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