Journals / Çocuk Enfeksiyon Dergisi / 2014 / Cilt: 8 - Sayı: 4

Akut odağı olmayan ateşli çocuklarda idrar yolu enfeksiyonunu öngörmede c-reaktif protein, prokalsitonin, interlökin-6 düzeylerinin değeri

The value of c-reactive protein, procalcitonin, ınterleukin-6 levels to predict urinary tract ınfection in children with fever without a focus

Pages
165–170
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: In conclusion, UTI is a frequent infection in 1-36-month-old children with fever without a focus, and the urine test with urine culture must certainly be assessed in these children.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: Urinary tract infections (UTIs) are one of the most common causes of acute fever without a focus in children between 1-36 months old, although obtaining urine for urine analysis is technically difficult in this age group.
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Key Findings & Data:The aim of this study is to determine the frequency of urinary tract infections in children between 1-36 months with acute fever of without a focus and the laboratory evi- dence, like C-reactive protein, procalcitonin, and inter- leukin-6 levels, that would help to predict urinary tract infections.
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Conclusion & Impact:Conclusion: In conclusion, UTI is a frequent infection in 1-36-month-old children with fever without a focus, and the urine test with urine culture must certainly be assessed in these children.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Objective: Urinary tract infections (UTIs) are one of the most common causes of acute fever without a focus in children between 1-36 months old, although obtaining urine for urine analysis is technically difficult in this age group. Therefore, there is a need for clinical and laboratory evidence to predict UTIs. The aim of this study is to determine the frequency of urinary tract infections in children between 1-36 months with acute fever of without a focus and the laboratory evi- dence, like C-reactive protein, procalcitonin, and inter- leukin-6 levels, that would help to predict urinary tract infections. Material and Methods: Febrile children presenting to a pediatric emergency department, ages ranging between 1-36 months old and body temperature being &#8805;38.0°C, with a source of fever that was unde- tectable clinically, were enrolled in this prospective study. Patients were evaluated according to clinical and laboratory findings. The data were analyzed using SPSS software, version 15.0. Results: A total of 90 patients were enrolled in this study. The median age was 7 months. The frequency of urinary tract infections was 25%. Escherichia coli was detected in all cases with positive urine cultures. There was no difference in clinical features between children with and without urinary tract infections. Laboratory findings, including white blood cell count, absolute neutrophil count, peripheral blood smear, and interleukin-6, were not statistically different between the two groups, whereas C-reactive protein and procalcitonin levels were significantly higher in the UTI group (p<0.05). Conclusion: In conclusion, UTI is a frequent infection in 1-36-month-old children with fever without a focus, and the urine test with urine culture must certainly be assessed in these children. Laboratory findings, including C-reactive protein and procalcitonin, can be used as supporting evidence. There is a need for large trials evaluating the value of interleukin-6 levels to predict urinary tract infections in children.

Özet

Amaç: Bir-36 ay grubu bebek ve çocuklarda “akut odağı belli olmayan ateşin” en sık nedenlerinden biri idrar yolu enfeksiyonu (İYE) olmasına rağmen bu yaş grubu çocuklarda idrar değerlendirmesi için idrar örneği alma teknik olarak zordur. Bu nedenle İYE öngörmek için kullanılabilecek klinik ve laboratuar bulgulara ihtiyaç vardır. Bu çalışmanın amacı, bir–36 ay arasındaki akut odağı belli olmayan ateş tanısı alan olgularda İYE saptanma sıklığını, İYE öngörme- ye yardımcı olabilecek klinik özelliklerin ve C-reaktif protein, prokalsitonin, interlökin-6 düzeylerinin sap- tanmasıdır. Gereç ve Yöntemler: Çocuk Acil Servisine ateş sebe- biyle başvuran ve başvuru sırasında ateşi ≥38,0°C saptanan yaşları bir -36 ay arası olan “akut odağı olmayan ateş” tanısı alan olgularda ileriye dönük ola- rak yapıldı. Olgular klinik ve laboratuar bulgular yönünden değerlendirildi. Verilerin analizi SPSS for Windows 15,0 programında yapıldı. Bulgular: Çalışma grubunun (n=90) yaş ortancası 7 ay (1-36) olup İYE sıklığı %33,3 olarak saptandı. İdrar kültüründe üreme saptanan olguların hepsinde Escherichia coli üredi. İdrar yolu enfeksiyonu olan ve olmayan çocuklarda klinik özellikler yönünden fark saptanmadı. Laboratuar bulgulardan beyaz küre, absolü nötrofil sayısı, periferik yayma bulguları ve interlökin-6 arasında fark saptanmazken C-reaktif protein ve prokalsitonin düzeyleri İYE grubunda daha yüksek saptandı (p<0,05). Sonuç: Sonuç olarak 1-36 ay arası akut odağı olma- yan ateşi olan çocuklarda İYE sık görülen bir enfeksi- yon olup çocuklar mutlaka idrar ve idrar kültürü ile değerlendirilmelidir. Laboratuar bulgulardan C-reaktif protein ve prokalsitonin destekleyici bulgu olarak kul- lanılabilir. Çocuklarda idrar yolu enfeksiyonunu öngör- mede interlökin-6 düzeylerinin değerlendirildiği daha geniş kap- samlı çalışmalara ihtiyaç vardır.

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Cite This Article

TAŞAR, M. A., DEMİR, H., ATAY, G., ARIKAN, F. İ., DALLAR, Y. B. (2014). Akut odağı olmayan ateşli çocuklarda idrar yolu enfeksiyonunu öngörmede c-reaktif protein, prokalsitonin, interlökin-6 düzeylerinin değeri. Çocuk Enfeksiyon Dergisi, Cilt: 8 - Sayı: 4, 165–170. https://ajindex.com/articles/198963

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References (6)

  1. Nield LS, Kamat D. Fever without a focus. Kliegman R, Stanton B, Schor N, Geme III J, Behrman R, (eds). Nelson Textbook of Pediatrics. 19th edition, 2011: Elsevier/ Saunders, Philadelphia. Chapter 170. p: 896-9
  2. Baraff LJ. Management of infants and young children with fever without source. Pediatr Ann 2008; 37: 673-9. [CrossRef] 3. Baraff LJ. Management of fever without source in infants and children. Ann Emerg Med 2000; 36: 602-14. [CrossRef] 4. Shaw KN, Gorelick M, McGowan KL, Yakscoe NM, Schwartz JS. Prevalence of urinary tract infection in febrile young child- ren in the emergency department. Pediatrics 1998; 102: e16. [CrossRef] 5. Hoberman A, Chao HP, Keller DM, Hickey R, Davis HW, Ellis D. Prevalence of urinary tract infection in febrile infants. J Pediatr 1993; 123: 17. [CrossRef] 6. Bachur R, Harper MB. Reliability of the urinalysis for predic- ting urinary tract infections in young febrile children. Arch Pediatr Adolesc Med 2001; 155: 60-5. [CrossRef] 7. Shaikh N, Morone NE, Bost JE, Farrell MH. Prevalence of urinary tract infection in childhood: a meta-analysis. Pediatr Infect Dis J 2008; 27: 302-8. [CrossRef] 8. Hoberman A, Wald ER. Urinary tract infections in young febrile children Pediatr Infect Dis J 1997; 16: 11-7. [CrossRef] 9. Ünal B, Delibaş A, Kuyucu N. Odağı belli olmayan düşük riskli ateşli çocuklarda idrar yolu enfeksiyonu sıklığını belir- lemede çeşitli idrar inceleme yöntemlerinin karşılaştırılması. J Pediatr Int 2011; 5: 47-53
  3. Tuygun N, Tanır G. Yaşı 0-36 aylık çocuklarda akut odağı olmayan ateş. J Pediatr Inf 2008; 2: 162-6
  4. Parlak M, Bayram Y, Çıkman A, Berktaş M. CRP düzeyinde zamana bağlı değişim. Van Tıp Dergisi 2013; 20: 13-7
  5. Elder JS. Urinary tract infections. Kliegman R, Stanton B, Schor N, Geme III J, Behrman R, (eds). Nelson textbook of pediatrics. 19th edition, 2011: Elsevier/Saunders, Philadelphia. Chapter 532. p: 1829-34
  6. Bouguila J, Khalef I, Charfeddine B, et al. Comparative study of C-reactive protein and procalcitonin in the severity diagnosis of pyelonephritis in children. Pathol Biol 2013; 61: 93-8. [CrossRef] 14. Leroy S, Fernandez-Lopez A, Nikfar R, et al. Association of procalcitonin with acute pyelonephritis and renal scars in pediatric UTI. Pediatrics 2013; 131: 870-9. [CrossRef] 15. Chen SM, Chang HM, Hung TW, et al. Diagnostic perfor- mance of procalcitonin for hospitalised children with acute pyelonephritis presenting to the paediatric emergency department. Emerg Med J 2013; 30: