Journals / Gülhane Tıp Dergisi / 2016 / Cilt: 58 - Sayı: 1

Leucocytoclastic vasculitis due to Ebstein-Barr virus infection in a child: case report

Bir çocuk hastada Ebstein-Barr virüs enfeksiyonuna bağlı gelişen lökoklastik vaskülit: olgu sunumu

Pages
102–104
DOI
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⚡ TL;DR(Too Long; Didn't Read)

Vasculitis in children should be considered as a rare complication of EBV infection in children and patients with EBV infection should be follow up in terms of vasculitis

📌 3 Key Takeaways

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Objective & Hypothesis:Leucocytoclastic vasculitis due to Ebstein-Barr virus infection in a child: case reportEBV is a DNA virus in Herpesviridae family.
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Key Findings & Data:A 5 years-old boy presented with fever, sore throat and maculopapular rash with no fading with pressure.
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Conclusion & Impact:Vasculitis in children should be considered as a rare complication of EBV infection in children and patients with EBV infection should be follow up in terms of vasculitis
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Leucocytoclastic vasculitis due to Ebstein-Barr virus infection in a child: case reportEBV is a DNA virus in Herpesviridae family. EBV infection can appear as subclinic course, infectious mononucleosis and EBV-associated malignancies. EBV infection may rarely cause some complications such as hemophagocytic lymphohystiositosis, splenic rupture, encephalitis, immunothrombocytopenic purpura, cholecystitis, lymphoproliferative disease and enteropathy. Herein, we report a boy diagnosed as leucocytoclastic vasculitis as a rare complication of EBV infection. A 5 years-old boy presented with fever, sore throat and maculopapular rash with no fading with pressure. She was on amoxicilline treatment for tonsillitis for 4 days and the rash was emerged after the fever disappeared. The amoxicilline treatment was stopped in case of drug-induced rash. However, the rash was spread through the body. In serological studies, antibodies against EBV were detected as anti-VCA IgM 2+, anti-EBNA IgM negatif, anti-EA-D IgG 3+ and consistent with acute EBV infection. She was administered intravenously immunoglobuline for 5 days. The rash was completely disappeared on the 6th day of treatment. Vasculitis in children should be considered as a rare complication of EBV infection in children and patients with EBV infection should be follow up in terms of vasculitis

Özet

Ebstein-Barr virusu (EBV), Herpes virüs ailesinden bir DNA virusudur. EBV enfeksiyonu, subklinik seyir, enfeksiyöz mononükleoz veya EBV-ilişkili maliniteler şeklinde ortaya çıkabilmektedir. EBV enfeksiyonu, nadir olarak hemofagositik lenfohistiositoz, dalak rüptürü, ensefalit, immünotrombositopenik purpura, kolesistit, obstrüktif uyku apnesi, lenfoproliferatif hastalık, enteropati gibi bazı komplikasyonlara neden olabilmektedir. Biz burada, EBV enfeksiyonunun çok nadir bir komplikasyonu olarak lökostoklastik vaskülit tanısı alan bir çocuk hasta sunuyoruz. Beş yaşında erkek hasta ateş, boğaz ağrısı ve vücutta basınca solmayan makulopapüler lezyonlar nedeniyle ile başvurdu. Hasta 4 gündür tonsillit için amoksisilin kullanıyordu ve ateşin düşmesi ile beraber döküntü başlamıştı. Hastadaki döküntülerin ilaca bağlı döküntü olabileceği düşünülerek, amoksisilin tedavisi kesildi, ancak döküntü tüm vücuda yayıldı. Serolojik çalışmalarda EBV' ye karşı oluşan antikor düzeyleri anti-VCA IgM 2+, anti-EBNA IgM negatif, antiEA-D IgG 3+ olarak saptandı ve akut EBV enfeksiyonu ile uyumluydu. Hastaya 5 gün intravenöz immünglobülin (IVIG) tedavisi verildi. Döküntüler tedavinin 6. gününde tamamen kayboldu. Çocuklarda vaskülit, EBV enfeksiyonunun nadir bir komplikasyonu olarak gözönünde bulundurulmalı ve EBV enfeksiyonu olan hastalar vaskülit açısından takip edilmelidir

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Cite This Article

KESİK, V., GÜLGÜN, M., TOPDEMİR, M., ERCİYAS, M., ATAŞ, E., FİDANCI, M. K., GÖK, F. (2016). Leucocytoclastic vasculitis due to Ebstein-Barr virus infection in a child: case report. Gülhane Tıp Dergisi, Cilt: 58 - Sayı: 1, 102–104. https://ajindex.com/articles/198363

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