Journals / GORM:Gynecology Obstetrics & Reproductive Medicine / 2015 / Cilt: 21 - Sayı: 1

Senkron Jinekolojik Kanserlerde İnsan Papilloma Virüsünün Rolü: İki Vaka Takdimi ve Literatür İncelemesi

The Role of Human Papilloma Virus in Synchronous Gynecologic Malignancies: A Report of Two Cases and Review of the Literature

Pages
46–48
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

Unlike cervical pathologies, HPV does not seem to play active role as etiologic agent in endometrial neoplasms, even detected synchronously with invasive cervical cancers.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium.
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Key Findings & Data:The first case is 68- year-old and the second case is 56 year-old postmenopausal woman who were diagnosed with invasive cervical carcinoma synchronously with endometrial carcinoma.
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Conclusion & Impact:Unlike cervical pathologies, HPV does not seem to play active role as etiologic agent in endometrial neoplasms, even detected synchronously with invasive cervical cancers.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim of the paper is to investigate the suspicious role of HPV in synchronous endometrial and cervical carcinomas and to discuss the relation between HPV and endometrium epithelium. The first case is 68- year-old and the second case is 56 year-old postmenopausal woman who were diagnosed with invasive cervical carcinoma synchronously with endometrial carcinoma. Following surgical procedures, high risk HPV DNA analysis using PCR were undertaken in both cases to investigate the possible role of HPV in synchronous malignancies. All endometrial samples were considered as negative for high risk HPV types however all cervical samples were considered as positive. Unlike cervical pathologies, HPV does not seem to play active role as etiologic agent in endometrial neoplasms, even detected synchronously with invasive cervical cancers.

Özet

Bu yazının amacı HPV’nin senkron endometrial ve servikal karsinomlardaki şüpheli rolünü araştırmak ve HPV ile endo- metriyum epiteli arasındaki ilişkiyi tartışmaktır. İlk vaka 68 ya- şında ikinci vaka 56 yaşında endometriyal karsinom ile senk- ron invazif servikal karsinomu bulunan postmenopozal kadın- lardan oluşmaktadır. Cerrahi işlemi takiben HPV’nin senkron malignensilerdeki muhtemel yerinin araştırılması amacıyla PCR ile yüksek riskli HPV DNA analizi yapılmıştır. Alınan tüm endometrial örnekler yüksek riskli HPV açısından negatif, alı- nan tüm servikal örnekler ise pozitif bulunmuştur. Servikal pa- tolojileri aksine HPV servikal kanser ile senkron görüldüğünde bile endometriyal neoplazilerde etyolojik ajan olarak aktif bir rol oynamıyor gibi görünmektedir.

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Cite This Article

TAŞKIN, S., PABUÇÇU, E. G., KAHRAMAN, A., YALÇIN, İ., ORTAÇ, U. F. (2015). Senkron Jinekolojik Kanserlerde İnsan Papilloma Virüsünün Rolü: İki Vaka Takdimi ve Literatür İncelemesi. GORM:Gynecology Obstetrics & Reproductive Medicine, Cilt: 21 - Sayı: 1, 46–48. https://ajindex.com/articles/198361

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References (7)

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