In this case report we will conclude about a case in which rapid development of akathisia and suicidal behavior occurs following venlafaxine treatment initiated with a non-psychiatric indication.
📌 3 Key Takeaways
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Objective & Hypothesis:Akathisia is a movement disorder characterized by an inner sense of unease, unrest and dysphoria.Suicidal behavior related with akathisia in patients is one of serious harmful behaviors and requires rapid intervention.There is limited number of cases about venlafaxine-associated akathisia in the literature, but it is not still yet known exactly what the actual incidence is.Side effects associated with antidepressants should be closely monitored and should be kept in mind without irreversible conditions.
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Key Findings & Data:Akathisia is a movement disorder characterized by an inner sense of unease, unrest and dysphoria.Suicidal behavior related with akathisia in patients is one of serious harmful behaviors and requires rapid intervention.There is limited number of cases about venlafaxine-associated akathisia in the literature, but it is not still yet known exactly what the actual incidence is.Side effects associated with antidepressants should be closely monitored and should be kept in mind without irreversible conditions.
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Conclusion & Impact:In this case report we will conclude about a case in which rapid development of akathisia and suicidal behavior occurs following venlafaxine treatment initiated with a non-psychiatric indication.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters
Abstract
Akathisia is a movement disorder characterized by an inner sense of unease, unrest and dysphoria.Suicidal behavior related with akathisia in patients is one of serious harmful behaviors and requires rapid intervention.There is limited number of cases about venlafaxine-associated akathisia in the literature, but it is not still yet known exactly what the actual incidence is.Side effects associated with antidepressants should be closely monitored and should be kept in mind without irreversible conditions. In this case report we will conclude about a case in which rapid development of akathisia and suicidal behavior occurs following venlafaxine treatment initiated with a non-psychiatric indication.
Özet
Akatizi öznel bir huzursuzluk hissi ve baskılanamayan hareket isteği ile karekterizedir. Hastalarda akatizi ile bağlantılı olarak görülebilen özkıyım davranışı ise ciddi zarar verici davranışlardan biridir ve hızlı müdahale gerektirir. Venlafaksine bağlı akatizi olguları yazına bakıldığında birkaç olgu olarak bildirilmiş olmakla birlikte gerçek görülme oranının ne olduğu henüz tam bilinmemektedir. Antidepresanlara bağlı yan etkilerin çok yakından takip edilmesi ve geri dönüşümsüz durum ortaya çıkmadan hızlı müdahale edilmesi gerektiği unutulmamalıdır Biz bu yazımızda psikiyatri dışı bir endikasyonla başlanan venlafaksin tedavisini takiben, hızlı gelişen akatizi ve özkıyım girişimi ortaya çıkan bir olguyu tartışmayı amaçladık.
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Cite This Article
GÜNDÜZ, N., AKCIL, E. F., TURAN, H. S., AKBEY, Z. Y. (2018). A rare case with suicide due to akathisia after use of single dose venlafaxine. Klinik Psikiyatri Dergisi, Cilt: 21 - Sayı: 2, 200–203. https://ajindex.com/articles/197829
Sachdev P. The development of the concept of akathisia: A historical overview. Schizophr Res 1995;16:33-45
Sachdev P. Acute and tardive drug-induced akathisia. DrugInduced Movement Disorders. Edited by Sethi KD. New York, Marcel Dekker Inc, 2004, pp.129-164
Basu B, Gangopadhyay T, Dutta N, Mzndall B, De S, Mondal S. A case of akathisia induced by escitalopram: Case report and review of literature. Curr Drug Saf 2014;9:56-59
Eberstein S, Adler LA, Angrist B. Nefazodone and akathisia. BiolPsychiatry 1996;40:798-799
Ng J, Sansone RA, McDonald S. Akathisia and abnormal movements of the upper extremities with venlafaxine and methimazole. Gen Hosp Psychiatry 2009;31:388-390
Lai CH. Venlafaxine-related akathisia side-effects and management in a depressed patient. Psychiatry Clin Neurosci 2013; 67:127-128
George M, Campbell JJ. 3rd Venlafaxine causing akathisia: A case report. J Neuropsychiatry Clin Neurosci 2012;24:3-4
Grover S, Valaparla VL. Venlafaxine induced akathisia: A case report. Indian J Pharmacol 2014; 46:660-661
Ceylan ME, Evrensel A. Venlafaxine induced akathisia: A case report. Trends Psychiatry Psychother 2016; 38:117
İzci F, Zincir SB, Acar G, Semiz UB. Duloxetine and venlafaxine induced akathisia: Two case reports. Bulletin of Clinical Psychopharmacology 2013;23:357-360
DiMascio M, DiGiovanni G, DiMatteo V, Prsico S, Esposito E. Selective serotonin reuptake inhibitors reduce the spontaneus activity of dopaminergic neurons in the ventral tegmental area. Brain Res Bull 1998;46:547-554
Sachdev P. The epidemiology of drug-induced akathisia: Part I acute akathisia. Schizophr Bull 1995;21:431-449
Gill HS, DeVane CL, Risch SC. Extrapyramidal symptoms associated with cyclic antidepressant treatment: A review of the literature and consolidating hypotheses. J Clin Psychopharmacol 1997;17:377-389
Lane RM. SSRI- induced extrapyramidal side-effects and akathisia: Implications for treatment. J Psychopharmacol 1998; 12:192-214
Miller M, Swanson SA, Azrael D, Pate V, Stürmer T. Antidepressant dose, age, and the risk of deliberate self-harm. JAMA Intern Med 2014;174:899-909
FDA (2014) Antidepressant use in children, adolescents, and adults. 12 Kasım 2017'de www.fda.gov/downloads/Drugs/DrugSafety/nformationbyDrug Class/UCM173233.pdf adresinden indirildi
Sharma T, Guski LS, Freund N, Gotzsche PC. Suicidality and agression during antidepressant treatment: Systemic review and meta-analyses base