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Journals / Haseki Tıp Bülteni / 2018 / Cilt: 56 - Sayı: 4

Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum

Hiperemezis Gravidarumda Serum İskemi Modifiye Albümin ve İskemi Modifiye Albümin/Albümin Oranının Değerlendirilmesi

Fatma BEYAZIT
Eren PEK
Hakan TURKON
Pages
292–298
DOI
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AI Summary & Key Takeaways

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⚡ TL;DR(Too Long; Didn't Read)

Conclusion: Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment.

📌 3 Key Takeaways

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Objective & Hypothesis:Aim: Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency.
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Key Findings & Data:Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies.
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Conclusion & Impact:Conclusion: Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Aim: Hyperemesis gravidarum (HEG) is characterized by severe nausea and vomiting, weight loss and nutritional deficiency. Although exact cause of this condition is still a matter of debate, contribution of oxidative stress to pathogenesis of HEG was demonstrated in some studies. The aim of this study was to investigate the diagnostic value of ischemia-modified albumin (IMA) concentration and IMA/albumin ratio (IMAR) in HEG patients. Methods: One patient group and two control groups were constituted. Pregnant subjects with HEG were included in HEG group (n=31) and age-, gestational age-, and body mass index (BMI)-matched healthy pregnant women in control group (n=30). The second control group was constituted from age- and BMI-matched non-pregnant women (n=30). Serum IMA, IMAR blood glucose, albumin, urea, creatinine, alanine aminotransferase and aspartate aminotransferase levels were measured in all subjects. Results: Serum median IMA levels [0.55 (0.43-0.68)] was found to be elevated in HEG patients compared with pregnant [0.52 (0.34-0.61)] and non-pregnant controls [0.48 (0.27-0.57)] (p=˂0.001). IMAR levels were also found to be significantly elevated in HEG patients compared to both control groups. According to correlation analysis, IMA and IMAR levels were only correlated with C-reactive protein levels. Conclusion: Elevated levels of IMA and IMAR in HEG patients might be due to ischemic intrauterine environment.

Özet

Amaç: Hiperemezis gravidarum (HEG) erken gebelikte gözlenen, ağır bulantı ve kusma, kilo kaybı ve nütrisyonel eksikliklerle karakterize tıbbi bir durumdur. Her ne kadar bu durumun nedeni tam olarak bilinmemekte ise de HEG patogenezinde oksidatif stresin katkısı birçok çalışmada gösterilmiştir. Bu çalışmanın amacı iskemi modifiye albüminin (İMA) ve İMA/albümin oranının (İMAO) HEG’deki tanısal rolünü araştırmaktır. Yöntemler: Çalışma için bir hasta grup ve iki kontrol grubu oluşturuldu. Gebe kadınlar HEG (n=31) yaş, gestasyonel yaş ve vücut kitle indeksi (VKİ) uyumlu kontrol grubu (n=30) olarak ayrıldı. İkinci kontrol grubu (n=30) ise gebe olmayan yaş ve VKİ uyumlu kadınlardan oluşturuldu. Gruplardaki serum İMA, İMAO, hemoglobin, lökosit, platelet, açlık kan şekeri, albümin, üre, kreatinin, alanin aminotransferaz, aspartat aminotransferaz ve tiroid stimule edici hormon değerleri ölçüldü. Bulgular: HEG hastalarında serum medyan İMA düzeyleri [0,55 (0,43-0,68)] gebe kontrol grubu [0,52 (0,34-0,61)] ve sağlıklı kontrol [0,48 (0,27-0,57)] grubu ile kıyaslandığında istatistiksel olarak yüksek idi (p=˂0,001). İMAO düzeyleri de benzer şekilde HEG hastalarında istatistiksel olarak yüksek saptandı. İMA ve İMAO seviyeleri ile C-reaktif protein düzeyleri arasında korelasyon belirlendi. Sonuç: HEG’de artmış olarak saptanan serum İMA ve İMAO düzeyleri artmış oksidatif stresin periferik yansıması olarak değerlendirilebilir

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Cite This Article

BEYAZIT, F., PEK, E., TURKON, H. (2018). Serum Ischemia-Modified Albumin Concentration and Ischemia-Modified Albumin/Albumin Ratio in Hyperemesis Gravidarum. Haseki Tıp Bülteni, Cilt: 56 - Sayı: 4, 292–298. https://ajindex.com/articles/197317

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