AI Summary & Key Takeaways
AI InsightConclusion: We conclude that paracetamol is a safe and effective treatment option in post-cesarean pain for combination with tramadol, as it produces effective analgesia and reduces tramadol consumption.
📌 3 Key Takeaways
Abstract
Objectives: In this study, the effects and side effects of intravenous paracetamol application, combined with patient-controlled intravenous tramadol analgesia, were investigated in elective cesarean operations for postoperative pain control and its tramadol-sparing effect. Methods: Fifty ASA I-II patients scheduled for cesarean operation were enrolled in this study. Patients were randomly divided into two groups: group I served as a control group, with saline administration (100 ml) 15 min before the end surgery and every 6 h for 24 h, whereas group II received paracetamol (1 g/100 ml) at the stated time points. All patients received a standard anesthetic protocol. At the end of surgery, all patients received tramadol i.v. via a PCA (patient-controlled analgesia) device. Pain and sedation scores were assessed at 1, 3, 6, 12 and 24 h postoperatively. Results: Tramadol consumption and adverse effects were noted in the first 24 hours following surgery. The pain scores were significantly lower in the paracetamol group when compared with the control group (p<0.05). The cumulative tramadol consumption was lower in the paracetamol group than the control group (p<0.05). No significant difference was observed in sedation scores and nausea-vomiting scores between the groups (p>0.05). Conclusion: We conclude that paracetamol is a safe and effective treatment option in post-cesarean pain for combination with tramadol, as it produces effective analgesia and reduces tramadol consumption.
Özet
Amaç: Bu çalışmada, sezaryen operasyonlarında hasta kontrollü analjezide (HKA) intravenöz (iv) tramadol ile kombine edilen iv parasetamolün postoperatif ağrı kontrolü ve tramadol kullanımı ve yan etkileri araştırıldı. Gereç ve Yöntem: Sezaryen operasyonu geçirecek ASA I-II grubu 50 hasta çalışmaya dahil edildi. Hastalar randomize olarak iki gruba ayrıldı ve bütün olgulara standart genel anestezi uygulandı. Grup I’e operasyon sonlanmadan 15 dk önce ve operasyon sonrası 6 saat ara ile 100 cc serum fizyolojik, grup II’ye ise aynı zaman aralıklarında 1gr iv parasetamol ilk 24 saat verildi. Cerrahinin sonunda olgulara iv HKA cihazı ile tramadol uygulandı. Ağrı ve sedasyon skorları 1., 3., 6., 12. ve 24. saatlerde değerlendirildi. Bulgular: Çalışma sonunda tramadol tüketimi ve yan etkiler kaydedildi. Ağrı skorları ve tramadol tüketimi parasetamol grubunda, kontrol grubuna göre daha düşük bulundu (p 0.05). Sonuç: Sonuç olarak sezaryen operasyonları sonrası tramadol ile birlikte kullanılan parasetamol güvenilir ve etkin bir analjezi sağlamakta, tramadol tüketimini azaltmaktadır.