Adipokine Levels and Perilipin Gene Polymorphisms in Obese Turkish Adolescents with Non-Alcoholic Fatty Liver Disease

Results: Overall, 83 obese adolescents with NAFLD, 123 obese adolescents with normal liver, and 102 healthy non-obese adolescents as the control group were evaluated.

📌 3 Key Takeaways

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Objective & Hypothesis:Objective: The aim of the present study was to evaluate the relationship between adipokines and perilipin (PLIN) polymorphisms with non-alcoholic fatty liver disease (NAFLD).

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Key Findings & Data:Serum leptin, adiponectin, resistin, and ghrelin levels and PLIN gene analysis (PLIN 1, 4, and 6) were studied in all patients and healthy control group.

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Conclusion & Impact:Results: Overall, 83 obese adolescents with NAFLD, 123 obese adolescents with normal liver, and 102 healthy non-obese adolescents as the control group were evaluated.

🔬Design:Research Article

📍Scope:Comprehensive Sample

⚙️Variables:Domain Parameters

Özet

Objective: The aim of the present study was to evaluate the relationship between adipokines and perilipin (PLIN) polymorphisms with non-alcoholic fatty liver disease (NAFLD). Methods: Obese Turkish adolescents were assessed in the study. The patients were divided into two groups: obese (NAFLD and non-NAFLD) and non-obese. Serum leptin, adiponectin, resistin, and ghrelin levels and PLIN gene analysis (PLIN 1, 4, and 6) were studied in all patients and healthy control group. Data obtained were compared with those of healthy control group. Results: Overall, 83 obese adolescents with NAFLD, 123 obese adolescents with normal liver, and 102 healthy non-obese adolescents as the control group were evaluated. No significant difference was observed in terms of serum adipokine (leptin, adiponectin, resistin, and ghrelin) levels in patients with NAFLD and non-NAFLD obese adolescents. The incidence of major alleles of PLIN 6 genotype in obese adolescents without NAFLD was slightly higher than that in the control group (p=0.06). PLIN 6 minor allele incidence was significantly lower (p=0.01), and PLIN 4 major allele frequency in patients with NAFLD was slightly lower than those in the control group (p=0.05). Conclusion: These findings suggested that no adipokine role was determined in the development of fatty liver in obese adolescents. The low rate in PLIN 6 minor allele can be a risk factor for NAFLD in adolescents.

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Cite This Article

TOKGÖZ, Y., ERDUR, C. B., AKBARİ, S., KÜME, T., SAYIN, O., TERLEMEZ, S., BAĞRIYANIK, Ş. E. E., ARSLAN, N. (2018). Adipokine Levels and Perilipin Gene Polymorphisms in Obese Turkish Adolescents with Non-Alcoholic Fatty Liver Disease. Erciyes Medical Journal, Cilt: 40 - Sayı: 2, 65–69. https://ajindex.com/articles/195371

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References (4)

Birkenfeld AL, Shulman GI. Nonalcoholic fatty liver disease, hepatic insulin resistance, and type 2 diabetes. Hepatology 2014;59(2):71323. [CrossRef] Arslan N. Obesity, fatty liver disease and intestinal microbiota.World J Gastroenterol 2014;28;20(44): 16452-63.
Paschos P, Paletas K. Non alcoholic fatty liver disease and metabolicsyndrome. Hippokratia 2009; 13(1): 9–19.
Osumi T, Kuramoto K. Heart lipid droplets and lipid droplet-binding proteins: Biochemistry, physiology, and pathology. Exp Cell Res 2016; 340(2): 198-204. [CrossRef] Brasaemle DL. The perilipin family of structural lipid droplet proteins: stabilization of lipid droplets and control of lipolysis. J Lipid Res 2007; 48: 2547-59. [CrossRef] Brasaemle DL, Subramanian V, Garcia A, Marcinkiewicz A, Rothenberg A. Perilipin A and the control of triacylglycerol metabolism.Mol Cell Biochem 2009; 326: 15-21. [CrossRef] Imai Y, Boyle S, Varela GM, Caron E, Yin X, Dhir R, et al. Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression. Physiol Genomics 2012; 44: 1125-1131. [CrossRef] Carr RM, Patel RT, Rao V, Dhir R, Graham MJ, Crooke RM, et al. Reduction of TIP47 improves hepatic steatosis and glucose homeostasis in mice. Am J Physiol Regul Integr Comp Physiol 2012; 302: 996-1003. [CrossRef] Ikura Y, Caldwell SH. Lipid droplet-associated proteins in alcoholic liver disease: a potential linkage with hepatocellular damage. Int J Clin Exp Pathol 2015;8(8): 8699-708
Caldwell SH, Ikura Y, Iezzoni JC, Liu Z. Has natural selection in human populations produced two types of metabolic syndrome (with and without fatty liver)? J Gastroenterol Hepatol 2007;22 Suppl 1: 11-19. [CrossRef] Straub BK, Stoeffel P, Heid H, Zimbelmann R, Schirmacher P. Differential pattern of lipid droplet-associated proteins and de novo perilipin expression in hepatocyte steatogenesis. Hepatology 2008; 47: 193646. [CrossRef] Smith CE, Ordovás JM. Update on perilipin polymorphisms and obesity. Nutr Rev 2012; 70(10): 611–621. [CrossRef] Tokgöz Y, Işık IA, Akbari S, Kume T, Sayın O, Erdal E et al. Perilipin polymorphisms are risk factors for the development of obesity in adolescents? A case-control study.Lipids Health Dis 2017; 9: 16(1): 52. Cole TJ, Lobstein T.Extended international (IOTF) body mass index cut-offs for thinness, overweight and obesity. Pediatr Obes 2012; 7: 284-94. [CrossRef] Quin SF, Gosink BB. Characteristic sonographic signs of hepatic fatty infiltration. Am J Roentgenol