SavedAdd your journal

Journals / Turkish Journal of Biology / 2021 / Cilt: 45 - Sayı: 2

IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice

Deming Lİ
Ze WANG
Chunyan ZHANG
Cunshuan XU
Pages
225–234
Publication Date
2021-04-20
DOI
—
🏛️Bibliographic metadata and full text access for this article are provided via DergiPark.
DergiPark Record ↗
✨

AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

There was stronger activation of proapoptotic proteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well.
📊
Key Findings & Data:The purpose of this experiment was to determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice.
💡
Conclusion & Impact:There was stronger activation of proapoptotic proteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Aged mice · IL-1R1 · inflammation

Abstract

Inflammation has a dual effect: it can protect the body and destroy tissue and cell as well. The purpose of this experiment was to determine the role of IL-1R1 in liver regeneration (LR) after partial hepatectomy (PH) in aged mice. The wild-type (WT, n = 36) and the IL-1R1 knockout (KO, n = 36) 24-month-old C57BL/6J mice underwent two-thirds PH; 33 WT mice underwent sham operation. Liver coefficient was calculated by liver/body weight. The mRNA and protein expressions of genes were evaluated by quantitative real-time polymerase chain reaction (qRT-PCR) and Western blotting methods, respectively. Compared with WT mice, liver coefficient was lower in the IL-1R1 KO aged mice at 168 and 192 h (p = 0.039 and p = 0.027). The mRNA transcription of inflammation-related genes and cell cycle-associated genes decreased or delayed. The protein expressions of proliferation-related marker PCNA and proliferation-associated signaling pathway components JNK1, NF-kappa B and STAT3 reduced or retarded. There was stronger activation of proapoptotic proteins caspase-3, caspase-8 and BAX in the IL-1R1 KO mice at different time points (p

🔖

Cite This Article

Lİ, D., WANG, Z., ZHANG, C., XU, C. (2021). IL-1R1 deficiency impairs liver regeneration after 2/3 partial hepatectomy in aged mice. Turkish Journal of Biology, Cilt: 45 - Sayı: 2, 225–234. https://ajindex.com/articles/192659

📄 Full Text PDF Viewer

📄

PDF görüntüleyici hazırlanıyor...

References (10)

  1. Alcaraz-Quiles J, 2017,
  2. HEPATOLOGY, V65, P202, DOI 10.1002/hep.28896 Boraschi D, 2013, SEMIN IMMUNOL, V25, P394, DOI 10.1016/j.smim.2013.10.023 Brenner C, 2013, J HEPATOL, V59, P583, DOI 10.1016/j.jhep.2013.03.033 Chen CJ, 2007, NAT MED, V13, P851, DOI 10.1038/nm1603 Cressman DE, 1996,
  3. SCIENCE, V274, P1379, DOI 10.1126/science.274.5291.1379 Das M, 2011, GENE DEV, V25, P634, DOI 10.1101/gad.1989311 Dinarello C A, 1997, Semin Oncol, V24, pS9. Dinarello CA, 1996,
  4. BLOOD, V87, P2095, DOI 0.1182/blood.V87.6.2095.bloodjournal8762095 Fausto N, 2006,
  5. HEPATOLOGY, V43, pS45, DOI 10.1002/hep.20969 Feng XD, 2019, NAT MED, V25, P575, DOI 10.1038/s41591-019-0358-x Franceschi C, 2000, ANN NY ACAD SCI, V908, P244 Fujiyoshi M, 2011, J HEPATO-BIL-PAN SCI, V18, P13, DOI 10.1007/s00534-010-0304-2 Furuya S, 2013, J SURG RES, V184, P838, DOI 10.1016/j.jss.2013.03.033 Gee JR, 2005, EXP GERONTOL, V40, P409, DOI 10.1016/j.exger.2005.01.010 Gehrke N, 2018, J HEPATOL, V68, P986, DOI 10.1016/j.jhep.2018.01.008 Glaccum MB, 1997, J IMMUNOL, V159, P3364. Goshen I, 2009, FRONT NEUROENDOCRIN, V30, P30, DOI 10.1016/j.yfrne.2008.10.001 Gunther S, 2017,
  6. IMMUNITY, V47, P510, DOI 10.1016/j.immuni.2017.08.004 Guo DH, 2020, J CLIN INVEST, V130, P1961, DOI 10.1172/JCI126078 Guttridge DC, 1999, MOL CELL BIOL, V19, P5785. Iakova P, 2003,
  7. CELL, V113, P495, DOI 10.1016/S0092-8674(03)00318-0 Ibrahim S, 2019, CYTOKINE GROWTH F R, V45, P65, DOI 10.1016/j.cytogfr.2018.12.003 Langiewicz M, 2018, J HEPATOL, V69, P666, DOI 10.1016/j.jhep.2018.04.017 Li W, 2002, J BIOL CHEM, V277, P28411, DOI 10.1074/jbc.M202807200 Livak KJ, 2001,
  8. METHODS, V25, P402, DOI 10.1006/meth.2001.1262 Luedde T, 2011, NAT REV GASTRO HEPAT, V8, P108, DOI 10.1038/nrgastro.2010.213 Majidinia M, 2017, DRUG RES, V67, P13, DOI 10.1055/s-0042-115405 Mitchell C, 2008, NAT PROTOC, V3, P1167, DOI 10.1038/nprot.2008.80 Moorlag SJCFM, 2020, CELL REP, V31, DOI 10.1016/j.celrep.2020.107634 MORELLO D, 1990,
  9. ONCOGENE, V5, P1511. Nazarloo HP, 2003, J NEUROIMMUNOL, V140, P102, DOI 10.1016/S0165-5728(03)00176-0 O'Neill LAJ, 1998, J LEUKOCYTE BIOL, V63, P650. Rhodes DM, 2015, PLOS ONE, V10, DOI 10.1371/journal.pone.0129888 Sabapathy K, 2004, MOL CELL, V15, P713, DOI 10.1016/j.molcel.2004.08.028 Sato T, 2019, LIFE SCI, V221, P293, DOI 10.1016/j.lfs.2019.02.040 Schaefer FM, 2015, BBA-MOL BASIS DIS, V1852, P137, DOI 10.1016/j.bbadis.2014.10.011 Seki E, 2012,
  10. GASTROENTEROLOGY, V143, P307, DOI 10.1053/j.gastro.2012.06.004 Song JQ, 2011, J SURG RES, V169,