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Journals / Gülhane Tıp Dergisi / 2016 / Cilt: 58 - Sayı: 1

Pulse radyofrekans uygulamasının pro-inflamatuar sitokin olan tnf-α üzerine etkisinin değerlendirilmesi

Assesment of pulsed radiofrequency’s effect on level of tnf-α as a proinflammatory cytokin

Şükrü TEKİNDUR
Süleyman DENİZ
Memduh YETIM
Tarık PURTULOĞLU
Abdülkadir ATIM
Ömer YANARATEŞ
Ercan KURT
Pages
78–81
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We also devise to develop this study by increasing number of patient and/or measuring other anti-inflammatory cytokines.

📌 3 Key Takeaways

🎯
Objective & Hypothesis:Pulsed Radiofrequency is a efficient method in chronic pain syndrome therapies.
📊
Key Findings & Data:We studied thirty 20-75 year-old patients with chronic pain syndrome and scheduled for pulsed radiofrequency in a prospective clinical trial.
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Conclusion & Impact:We also devise to develop this study by increasing number of patient and/or measuring other anti-inflammatory cytokines.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Pulsed Radiofrequency is a efficient method in chronic pain syndrome therapies. Working mechanism of pulsed radiofrequency is unknown and is currently being investigated. We studied thirty 20-75 year-old patients with chronic pain syndrome and scheduled for pulsed radiofrequency in a prospective clinical trial. Tumor necrosis factoralpha (TNF-α) levels, visual analogue scale scores and categorical pain scale scores before pulsed radiofrequency therapy were compared with results of third weeks after pulsed radiofrequency therapy in all cases. Mean level of TNF-α before a procedure is 5.230±3.858 and means level of TNF-α three weeks after procedure is 12.763±3.322. We found a statistically significant increase between TNF-α levels (p<0.05). Increase in second control of TNF-α levels may demonstrate that we aggravated inflammatory process. We also devise to develop this study by increasing number of patient and/or measuring other anti-inflammatory cytokines.

Özet

Pulse Radyofrekans kronik ağrı sendromlarının tedavisinde etkin bir yöntemdir. Pulse radyofrekansın çalışma mekanizması bilinmemektedir ve halen araştırılmaktadır. Biz, kronik ağrı sendromu olan 20-75 yaşları arasındaki pulse radyofrekans tedavisi uygulanan otuz hastaya bu prospektif klinik çalışmayı planladık. Tümör nekroz faktörü-alfa (TNF-?), görsel analog skala ve kategorik ağrı skalası düzeyleri tüm olgularda pulse radyofrekans tedavisi öncesi ve tedavi sonrası üçüncü hafta sonuçları ile karşılaştırıldı. TNF-?'nın tedavi öncesi değerleri 5,230±3,858 iken, tedavi sonrası üçüncü hafta sonuçları 12,763±3,322 idi. Biz TNF-? düzeyleri arasında istatistiksel olarak anlamlı bir artış bulduk (p <0.05). İkinci kontroldeki TNF-? düzeyindeki artış, inflamatuvar sürecin artırılmış olduğunu gösterebilir. Hasta sayısının artırılması ve/veya diğer anti-inflamatuar sitokinlerinde ölçülerek çalışmanın geliştirilmesini düşünmekteyiz.

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Cite This Article

TEKİNDUR, Ş., DENİZ, S., YETIM, M., PURTULOĞLU, T., ATIM, A., YANARATEŞ, Ö., KURT, E. (2016). Pulse radyofrekans uygulamasının pro-inflamatuar sitokin olan tnf-α üzerine etkisinin değerlendirilmesi. Gülhane Tıp Dergisi, Cilt: 58 - Sayı: 1, 78–81. https://ajindex.com/articles/191666

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