AI Summary & Key Takeaways
AI InsightCONCLUSIONS: Ovarian cysts larger than 8 cm, presence of solid area within the cyst, and postmenopausal status are the most important risk factors for ovarian malignancies in these patients withnormal CA-125 levels.
📌 3 Key Takeaways
Abstract
OBJECTIVE: We aimed to determine the diagnostic values of some clinical and ultrasonographic features for predicting ovarian malignancies in patients with normal serum CA-125 levels.STUDY DESIGN: All of the 84 patients who were diagnosed with ovarian malignancy and 168 patientswith benign adnexal mass had normal CA-125 levels, and recruited as study and control groups, respectively. Individual characteristics, ultrasonographic features, and risk of malignancy index (RMI) values of the groups were compared retrospectively.RESULTS: The ages, mean postmenopausal period of the postmenopausal women in the malignantgroup were significantly higher than the benign group. Nulliparity rates were similar between the twogroups. The number of postmenopausal patients was significantly higher in the malignant group. Mediancyst diameter and RMI values were significantly higher, and bilaterality and presence of solid area weremore frequent in this group. Logistic regression model showed that ovarian cysts larger than 8 cm [Oddsratio (OR): 7.012; p<0.001; 95% Confidence interval (CI): 3.463-14.198], presence of solid area withinthe cyst [OR: 7.43; p<0.001; 95% CI: 3.799-14.532], and postmenopausal state [OR: 2.893; p=0.027;95% CI: 1.129-7.412] were found to be significant factors to predict malignancy. CONCLUSIONS: Ovarian cysts larger than 8 cm, presence of solid area within the cyst, and postmenopausal status are the most important risk factors for ovarian malignancies in these patients withnormal CA-125 levels.