Journals / Ağrı / 2012 / Cilt: 24 - Sayı: 4

Convulsion due to application of low dose meperidine: A case report

Düşük doz meperidin uygulamasına bağlı konvulsiyon: Olgu sunumu

Journal
Ağrı
Pages
187–190
DOI
—
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AI Summary & Key Takeaways

AI Insight
⚡ TL;DR(Too Long; Didn't Read)

We used low dose meperidine due to post operative pains.

📌 3 Key Takeaways

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Objective & Hypothesis:Meperidine is an opiod analgesic used in a variety of clinical situations.
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Key Findings & Data:Previously identified risk factors for the development of meperidine-related seizures include renal failure, high meperidine dosages, and co-adminestration of hepatic enzyme inducing medications or phenothiazines which decreases seizure treshold.
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Conclusion & Impact:We used low dose meperidine due to post operative pains.
🔬Design:Research Article
📍Scope:Comprehensive Sample
⚙️Variables:Domain Parameters

Abstract

Meperidine is an opiod analgesic used in a variety of clinical situations. The active metabolite, normeperidine, is a central nervous system excitatory agent and has the ability to cause irritability, hyperreflexia, tremor, myoclonus and seizures. Previously identified risk factors for the development of meperidine-related seizures include renal failure, high meperidine dosages, and co-adminestration of hepatic enzyme inducing medications or phenothiazines which decreases seizure treshold. Patients with normal renal function rarely manifest seizure activity when given meperidine. Here we report a 10 year old boy with a femur fraction who had normal renal function. We used low dose meperidine due to post operative pains.

Özet

Meperidin pediatride çeşitli durumlarda kullanılan opoid analjeziktir. Meperidinin aktif metaboliti olan normeperidin merkezi sinir sistemi üzerine uyarıcı etkilidir. Meperidinin irritabilite, hiperrefleksi, tremor, miyoklonus ve nadiren konvülsif nöbete yol açabildiği literatürde yer almaktadır. Bu risk özellikle yüksek meperidin dozunda, hepatik enzimleri indükleyen ilaç kullanımında, böbrek yetersizliğinde ve nöbet eşiğini düşüren fenotiazinlerin kullanımı durumunda artmaktadır. Böbrek işlevi normal hastalarda meperidin kullanımına bağlı konvülsif nöbet literatürde nadir olarak bildirilmektedir. Femur kırığına bağlı şiddetli postoperatif ağrıları olan ve bu amaçla tedavide düşük doz meperidine kullanılan ve meperidine bağlı tonik-klonik konvülsif nöbet geçiren böbrek fonksiyonları normal 10 yaşındaki erkek hastayı sunmayı uygun bulduk.

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Cite This Article

ÖZKAYA, H., AKCAN, A. B., AYDEMİR, G., AKBAŞ, M. (2012). Convulsion due to application of low dose meperidine: A case report. Ağrı, Cilt: 24 - Sayı: 4, 187–190. https://ajindex.com/articles/186503

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References (13)

  1. Barsan WG, Tomassoni AJ, Seger D, Danzl DF, Ling LJ, Bartlett R. Safety assessment of high-dose narcotic analgesia for emergency department procedures. Ann Emerg Med 1993;22(9):1444-9
  2. Beaulé PE, Smith MI, Nguyen VN. Meperidine-induced seizure after revision hip arthroplasty. J Arthroplasty 2004;19(4):516-9
  3. Michaelis M, Schölkens B, Rudolphi K. An anthology from Naunyn-Schmiedeberg’s archives of pharmacology. Naunyn Schmiedebergs Arch Pharmacol 2007;375(2):81-4
  4. Kaiko RF, Foley KM, Grabinski PY, Heidrich G, Rogers AG, Inturrisi CE, et al. Central nervous system excitatory effects of meperidine in cancer patients. Ann Neurol 1983;13(2):180-5
  5. Donna Wong (2002-03-15). “Notes on Meperidine”. Wong on Web Papers. Elsevier. http://www.mosbysdrugconsult.com/ WOW/op024.html. Retrieved 2007-04-13
  6. Baselt R. Disposition of toxic drugs and chemicals in man. 8th ed. Foster City, CA: Biomedical Publications; 2008. p. 911- 4
  7. Package insert for meperidine hydrochloride. Boehringer Ingelheim, Ridgefield, CT: 2005
  8. Goetting MG, Thirman MJ. Neurotoxicity of meperidine. Ann Emerg Med 1985;14(10):1007-9
  9. Latta KS, Ginsberg B, Barkin RL. Meperidine: a critical review. Am J Ther 2002;9(1):53-68
  10. Gordon DB, Jones HD, Goshman LM, Foley DK, Bland SE. A quality improvement approach to reducing use of meperidine. Jt Comm J Qual Improv 2000;26(12):686-99
  11. Simopoulos TT, Smith HS, Peeters-Asdourian C, Stevens DS. Use of meperidine in patient-controlled analgesia and the development of a normeperidine toxic reaction. Arch Surg 2002;137(1):84-8
  12. Marinella MA. Meperidine-induced generalized seizures with normal renal function. South Med J 1997;90(5):556-8
  13. Kussman BD, Sethna NF. Pethidine-associated seizure in a healthy adolescent receiving pethidine for postoperative pain control. Paediatr Anaesth 1998;8(4):349-52.